Poster Sessions
Poster Session I
Wednesday, September 13, 2017 — 12:00 p.m. – 1:30 p.m. — FAES Terrace
Compact video monitoring systems for large-scale mouse ethology
Author(s): G Salem, J Krynitsky, M Garmendia, S Anderson, B Wang, A Nilacantan, J Pedersen, C Schultz, T Talbot, W Bennett, G Dold, JB Mitchell, AV Kravitz, JU Dennis, T Pohida
Examining the viewpoints and decision-making process of Sickle Cell Disease patients, parents, and physicians towards prospective participation in CRISPR-Cas9 clinical trials
Author(s): A Persaud, BA, VL Bonham, JD
The effect of experimental reduction of pain catastrophizing on pain perception, nociceptive flexion reflex, and temporal summation of the nociceptive flexion reflex as verified by mediation analyses
Author(s): EL Terry, KA Thompson, JL Rhudy
Determinants of hangover following intravenous alcohol self-administration in non-dependent drinkers
Author(s): BL Stangl, A Gogineni, E Corbin, LE Blau, V Vatsalya, VA Ramchandani
Dopamene transporter (DAT1) gene variation and intravenous alcohol self-administration in non-dependent drinkers: influence of sex differences
Author(s): CL Vaughan, BL Stangl, H Sun, ML Schwandt, F Lohoff, VA Ramchandani
The role of carving in human alcohol consumption in heavy and light drinkers: thinking about drinking
Author(s): JL Gowin, ME Sloan, VA Ramchandani
Binding elements into forms: Visual analysis of contour and form by infants and adults
Author(s): C Wei, MH Bornstein, C M
Early development of functional brain connectivity in infants’ recognition of familiar faces
Author(s): J Cui, C Mash, MH Bornstein
Effects of vertical symmetry on infants’ exploration and discrimination of images
Author(s): E Mistur, MH Bornstein, C Mash
Where are our former postdocs employed? Developing innovative visualization tools and a new career outcome taxonomy that provides insight into the employment trends of postdoc alumni from NIH | NIEHS
Author(s): TRL Collins, H Xu, RST Gilliam, SD Peddada, GM Buchold
Explore-exploit decision making: Differences in information-seeking behavior in pediatric psychopathology
Author(s): CE Swetlitz, BB Averbeck, E Leibenluft, DS Pine, D Pagliaccio
Measurement invariance and test-retest reliability of the SCARED questionnaire: examining parent and child report of anxiety symptoms
Author(s): BM Behrens, CE Swetlitz, K Kircanski, DS Pine, D Pagliaccio
The role of depressive symptoms in the aberrant processing of emotional stimuli in youth with severe irritability
Author(s): LK Meffert, P Vidal-Ribas, MA Brotman, E Leibenluft, A Stringaris
Who takes advantage of cigarette coupons and price promotions? Findings from the 2013-2014 National Adult Tobacco Survey
Author(s): K Choi
Cancer-Related Fatigue and the Adaptive Response to Oxidative Stress
Author(s): K Dickinson, D Wang, J Barb, JP Bennett, S Collins, D Lyon, LN Saligan
Developing Effective Strategies for Recruitment and Registration of Healthy Children In Research
Author(s): Cou Johnson, Mel Webb
High-throughput assay development for Niemann-Pick type A small molecule therapeutics
Author(s): K Gorshkov, M Xu, S Yang, W Zheng
Tocopherol enters cell through the endocytic pathway and regulates lysosomal exocytosis
Author(s): M Xu, ZD Shi, S Titus, BY Xu, RE Swenson, W Zheng
ZIKV infection elicit mitochondria fragmentation
Author(s): S Yang, K Gorshkov, M Xu, W Zheng
Microenvironmental mitochondria transfer support chemo-resistance in cancer cells
Author(s): Y Liu, Y Lu, A Li, H Song, W Zhang, MR Gilbert, C Yang
Co-culture with supporting cells of the developing heart promotes maturation of induced pluripotent stem cell-derived cardiomyocytes
Author(s): IH Garcia-Pak, W Li, H Uosaki, E Tampakakis, J Zou, Y Lin, Y Mukouyama
Functional characterization of Rbfox mediated protein interaction in skeletal muscle differentiation
Author(s): T Govindarajan, RS Adelstein, S Kawamoto
Illuminating mitophagy in living mt-Keima mouse tissues via super-resolution microscopy
Author(s): D Malide, N Sun, T Finkel
Structural-functional characterization of Plp
Author(s): R Varadarajan, K Plevock, CJ Fagerstrom, NM Rusan
Melanocortin 3 receptor (MC3R), a regulator of hepatic autophagy in obesity
Author(s): JY Jun, A Seo, P Patel, A Uhlman, T Patel, S Cai, F Famuyiwa, H Bednar, N Levi, R Roberson, A Demidowich, J Yanovski
TRAF3 serves as a tumor suppressor in HPV-associated head and neck squamous cell carcinomas
Author(s): TW Chen, J Zhang, X Yang, Z Chen, C Van Waes
Perlecan is essential for the functioning and repair of the blood-brain barrier through interacting with and activating pericytes in a mouse ischemic stroke model
Author(s): K Nakamura, T Ikeuchi, P Zhang, C Rhodes, Y Chiba, Y Mukouyama, Y Yamada
A user-friendly ImageJ macro for ratio imaging analysis of fluorescence microscopy images
Author(s): N Khattar, JM Reece
An Immortal Dorsal Root Ganglion Cell to Model Neuropathic Pain in Fabry Disease
Author(s): CR Kaneski, JA Hanover, UH Schueler
H3K4 Methyltransferase Activity Is Required for MLL4 Protein Stability
Author(s): Y Jang, C Wang, L Zhuang, C Liu, K Ge
Human, Murine, and In Vitro Studies Identify A Novel Retinol Dehydrogenase, HSD17B13 That Contributes to the Histological Severity of Non-Alcoholic Fatty Liver Disease
Author(s): Y MA, OV BELIAEVA, PM BROWN, K SUMAN, NY KEDISHVILI, Y ROTMAN
Mutations outside of Ure2 amyloid-forming region disrupt [URE3] prion propagation
Author(s): S Kumar, E Dine, E Paddock, DC Masison
The Effects of Exercise on Mitochondrial Function
Author(s): QH Nguyen, RL Feng, BL Yuan, RJ Domingo, A Nath, B Walitt, LN Saligan
Characterizing Small Molecule Inhibitors of ALDH1A1 with Biochemical, Biophysical, and High Throughput Cell-based Assays
Author(s): AS Yasgar, SM Yang, Y Wang, C Danchik, SA Titus, B Baljinnyam, DM Cheff, XS Wang, DJ Maloney, A Jadhav, M Lal-Nag, V Vasilou, U Opperman, A Simeonov, NJ Martinez
Discovery of Potent Small Molecule Inhibitors of Mutant Isocitrate Dehydrogenase 1
Author(s): S Karavadhi, JM Rohde, R Pragani, M Davis, D Urban, N Martinez, T Lee, D Cheff, K Brimacombe, L Liu, M Henderson, S Titus, Y Fang, P Shah, J Covey, M Davis, M Hollingshead, WJ Moore, A Mclver, H Zheng
Repurposing Drugs for ADPKD: Assay Development and High-throughput Screening
Author(s): C Danchik, R Asawa, A Zakharov, M Boutin, J Trott, D Wallace, A Simeonov, R Weiss, N Martinez
Application of oxime-diversification to optimize ligand interactions within a cryptic pocket of the polo-like kinase 1 polo-box domain
Author(s): XZ Zhao, D Hymel, TR Burke
Bivalent inhibitors that target the polo-box domain in polo-like kinase 1
Author(s): K Tsuji, D Hymel, TR Burke, Jr
Tunable protein release from a peptide hydrogel
Author(s): SE Miller, Y Yamada, S Tau, JP Schneider
Two-stage peptide hydrogels as sprayable miRNA depot for malignant pleural mesothelioma
Author(s): P Majumder, A Singh, C Hoang, JP Schneider
Novel bivalent ligands based on the sumanirole pharmacophore reveal dopamine D2 receptor (D2R) biased agonism and allosteric modulation
Author(s): A Bonifazi, H Yano, AM Guerrero, L Muller, A Woods, L Shi, G Tanda, AH Newman
A new natural product antibiotic reveals cellular uptake facilitated by the NorA multidrug efflux protein
Author(s): JR Davison, KM Lohith, S Mandadapu, K Bobyk, X Wang, J Piotrowski, HE Smith, CA Bewley
A Genome-Wide Screen Reveals a Replication-Independent Role of Dbf4-Dependent Kinase in Localization of the Centromeric Histone H3 Variant for Genome Stability
Author(s): JR Eisenstatt, L Boeckmann, WC Au, V Garcia, L Bursch, J Warren, M Costanzo, M Weinreich, R Sclafani, A Baryshnikova, C Meyers, C Boone, R Baker, MA Basrai
The Human Inner Kinetochore Associates with Structurally Distinct CENP-A Nucleosomes
Author(s): DP Melters, S Gregoryev, Y Dalal
Brd4 binds to active enhancers to control cell identity gene induction during differentiation
Author(s): J Lee, Y Park, K Ge
Depletion of Nsd2-mediated histone H3K36 methylation reprograms adipose tissue development and function
Author(s): L Zhuang, Y Jang, Y Park, J Lee, S Jain, E Froimchuk, C Liu, O Gavrilova, K Ge
TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration
Author(s): J Yoon, YS Hwang, M Lee, J Sun, L Knapik, IO Daar
Mutation in the splicing factor zrsr2 disrupts normal hematopoietic development in zebrafish
Author(s): EA Broadbridge, E Bresciani, W Pei, L Xu, B Carrington, M Jones, R Sood, SM Burgess, PP Liu
A Drosophila melanogaster screen reveals novel functions of primary microcephaly and primordial dwarfism genes
Author(s): RS O'Neill, CJ Fagerstrom, NM Rusan
Origin, Distribution and Functions of Neural Tube Microglia in the Immunoprivileged Central Nervous System
Author(s): C Liu, Y Mukouyama
Smooth muscle cell proliferation in fetal elastin heterozygous versus control mice, suggests mechanism underlying Williams Syndrome cardiac disease
Author(s): A Watson, M Levin, Z Yu, B Kozel
Live imaging of the lymphatic vascular network using transgenic zebrafish
Author(s): HM Jung, D Castranova, MR Swift, VN Pham, M Venero Galanternik, S Isogai, MG Butler, TS Mulligan, BM Weinstein
Sonic hedgehog in the developing auditory neurons is required to mediate both neuronal and cochlear development
Author(s): LS Wong, DK Wu
Pannexin 3 deficiency impairs skin development and delays wound healing in mice via its hemichannel and ER Ca2+ channel functions
Author(s): P Zhang, M Ishikawa, C Rhodes, A Doyle, T Ikeuchi, K Nakamura, Y Chiba, Y Yamada
The novel basic-Helix-Loop-Helix transcription factor AmeloD regulates tooth morphogenesis
Author(s): Y Chiba, B He, K Yoshizaki, S Fukumoto, Y Yamada
Measurement of Patient Acuity Related to Clinical Research: Concept Clarification and Review of the Literature
Author(s): CW Brennan, M Krumlauf, K Feigenbaum, K Gartrell, G Cusack
Role of Metabolite Identification in Lead Optimization of Fibrodysplasia Ossificans Progressiva Compounds
Author(s): EC Padilha, P Shah, A Wang, J Jiang, RG Peccinini, X Xu
CREx: One Stop Shopping for Core Facilities and Research Services at NIH
Author(s): L Darbha, M Malik, D Goldstein
NIH Foregut Team: Dedicated to clinical research and care of patients with cancers of the esophagus, stomach, pancreas, liver and bile ducts
Author(s): NIH Foregut Team
CDASH and SDTM for Clinical Trials and Reporting
Author(s): J Singh, H Kandaswamy, JD Otoo, P Gumne, M Duvenhage, CJ Whalen, M Tartakovsky
Custom-built protocols: planning and structuring a study to better serve the clinical research community
Author(s): BA Snow, SL Kopka, DG Chaitt, JF Pierson, TJ Miller
Fulfilling the needs of Researchers for an easy-to-use on & offline data capturing system
Author(s): N Moodley, M Duvenhage, K Bajwa, P Gumne, B Moyer, C Whalen, A Rosenthal, M Tartakovsky
Integrating clinical and laboratory data for exploration and analysis: Clinical Laboratory Information Portal (CLIP)
Author(s): MA Makiya, AJ Glogowski, HA Abbasi, T Ahmed, S Xu, KQ Chukwurah, BB Smith, AD Klion
Paper to Paperless: The implementation of an Electronic Regulatory Binder within DIR/ NIAID
Author(s): SE Vogel, L Imes, W Barrick, M Eisenberg, J Saadvandi, K Lyman, J Pierson
Preventing Pregnancy in Clinical Trials -- Efforts to Increase Contraception Adherence
Author(s): S Barber, K Cahill, A Adams, M Teitelbaum
Using FastFile as a large file sharing, management and replication hub for PET/CT scans for the PREDICT study (a global TB treatment research protocol)
Author(s): D Ireland, M Duvenhage, M Hurst, M Holdsworth, F Appiah, R Chen, C Whalen, M Tartakovsky
A Guide to Time Lag and Time Lag Shortening Strategies in Oncology-Based Drug Development
Author(s): B Uygur, J Duberman, S Ferguson
Classification of temporal trends in healthcare research databases in support of data quality and hypothesis generation
Author(s): YA Sumathipala, V Huser
Preserving NIH science at the National Library of Medicine:anoxic enclosure for the Marshall Nirenberg genetic code charts
Author(s): HT Herro, KL Wright, RA Clary, HE Metger, C Moffatt, JP Rees
Sharing of de-identified patient level data from human clinical trials: analysis of US-based studies in the ClinicalTrials.gov registry
Author(s): V Huser
Careers for NIH scientists in technology transfer & business development in 2017
Author(s): SM Ferguson, JW Thomas
NIH Exosome and Extracellular Vesicle Interest Group
Author(s): NIH EVIG, L Margolis, JC Jones
NIH scientists and the Federal Laboratory Consortium for Technology Transfer (FLC) in 2017
Author(s): AZ Amar, SM Ferguson, GK Jones
Software Tools for Studying Biomolecular Structure and Dynamics
Author(s): CD Schwieters, GA Bermejo
Conformational ensembles of SOS1 upon association with K-Ras4B
Author(s): T Liao, H Jang, D Fushman, R Nussinov
Quantitative Imaging of Immature Secretory Granules in Beta Cells of Mouse Pancreatic Islets by Serial Block-Face Scanning Electron Microscopy
Author(s): A Rao, EL McBride, G Zhang, T Cai, H Xu, AL Notkins, MA Aronova, RD Leapman
Structural insights of the human R7BP-Gβ5-RGS7 complex using cross-linking mass spectrometry
Author(s): PR Adikaram, JH Zhang, WF Simonds
Defining Exosome Profiles for Personalized Medicine with Mt-SEA Multiplex-to-Single EV Analysis Pipeline
Author(s): JA Welsh, J Kepley, A Rosner, A Barfield, K McKinnon, V Galli, J Savage, J Marte, K Conlon, T Waldmann, JA Berzofsky, G Franchini, K Camphausen, JC Jones
Machine learning analytics identify gene expression signatures of severe hypertension in African-Americans
Author(s): C Oguz, AR Davis, GH Gibbons
A role for PPAR alpha in regulating sex differences in cardiac hypertrophy
Author(s): N Fillmore, J Harrington, S Gao, Y Yang, X Zhang, P Liu, A Stoehr, Y Chen, D Springer, J Zhu, X Wang, E Murphy
Multi-Omics Comparative Analysis Reveals Host Signaling Pathways Affected by the Gut Microbiota
Author(s): NP Manes, N Shulzhenko, AG Nuccio, S Azeem, A Morgun, A Nita-Lazar
Effects of radiation-induced fatigue on motor function
Author(s): SA Raheem, B Wolff, R Feng, LN Saligan
Poster Session II
Wednesday, September 13, 2017 — 3:30 p.m. – 5:00 p.m. — FAES Terrace
Reduced opioid receptors and anhedonia in chronic pain
Author(s): Scott J. Thompson, Mark H. PItcher, Laura Stone, Farid Tarum, Gang Niu, Xiaoyuan Chen, Dale O. Kiesewetter, Petra Schweinhardt, M. Catherine Bushnell
High-Throughput 3D Imaging of the Human Genome
Author(s): Sigal Shachar, Gianluca Pegoraro, Ziad Jowhar, Armin Raznahan, Tom Misteli
Epoxide Hydrolase 1 Regulates Epoxyeicosanoid Hydrolysis and Postischemic Cardiac Recovery
Author(s): ML Eden, BG Hamedani, A Gruzdev, FB Lih, SJ Arbes III, R Singh, AC Orjuela Leon, JP Graves , JA Bradbury, LM DeGraff, SL Hoopes, M Arand, DC Zeldin
Dynamics in Weight Gain after Kidney Transplantation
Author(s): AK Cashion, Y-E Cho, C Lai, HS Kim
Detection of Autophagy in Human CD4+ T cells
Author(s): L Ferrucci, T Srinivas, A Bektas, R Sen
Comparison of 3-D subcellular imaging techniques based on scanned electron probes: application to blood platelet ultrastructure
Author(s): MA Aronova, Q He, MD Guay, RP Desai, MP Tobin, EL McBride, A Rao, G Zhang, ID Pokrovskaya, B Storrie , RD Leapman
Development of alternative systems for studying drug resistance in cancer
Author(s): MM Gottesman, W Wulftange, F Ali-Rahmani, A Robinson, L Huff, A Jaeger, N Morgan, TJ Pohida, K Tanner, R Robey
Age-dependent role of Armc5 in mouse adrenal: from hypo- to hyper function
Author(s): A Berthon, FR Faucz, S Espiard, L Drougat , J Bertherat, CA Stratakis
Integrated melanoma/melanoblast transcriptomics identifies novel metastasis regulators: A role for ER stress
Author(s): KL Marie, AM Michalowski, HT Michael, T Guo, YC Tsai, AM Weissman, HH Yang, MP Lee, MR Zaidi, E Pérez-Guijarro, A Sassano, C-P Day, H Arnheiter, S Davis, PS Meltzer, PJ Mishra , G Merlino
Our genes are falling apart with age: detectable mosaic events in large populations
Author(s): Mitchell J. Macheila, Weiyin Zhou, Neil Caporaso, Michael Dean, Susan M. Gapstur, Nathaniel Rothman, Victoria L. Stevens, Meredith Yeager, Stephen J. Chanock
Broadening our lens: Investigating the frequency of xeroderma pigmentosum by mining genomic databases
Author(s): JM Pugh, SG Khan, D Tamura, A Goldstein, JJ DiGiovanna, KH Kraemer
Comparative Analysis between Gene Expression Profile and Genomic Profile in Adrenocortical Carcinoma Samples
Author(s): FP Fortes, LM Canto, H Kuasne, KC de Andrade, SR Rogatto, MI Achatz
D3Oncoprint: Standalone software to visualize and dynamically explore annotated genomic mutation files
Author(s): A Palmisano, Y Zhao, RM Simon
Germline mutations in DNA repair genes are overrepresented in children and young adults with rhabdomyosarcoma: A discovery and validation cohort study
Author(s): T Wegman-Ostrosky, N Light, E Young, HC Chen, YY Chi, D Hall, DS Hawkins, J Kim, PJ Lupo, R Patidar, A Shlien, S Skapek, M Tyagi, J Wei, JD Schiffman, J Khan, D Malkin, DR Stewart
Higher-than-expected population prevalence of potentially pathogenic germline TP53 variants in individuals unselected for cancer history
Author(s): KC de Andrade, L Mirabello, DR Stewart, E Karlins, R Koster, M Wang, SM Gapstur, MM Gaudet, ND Freedman, MT Landi, N Lemonnier, P Hainaut, SA Savage, MI Achatz
NCI Office of Cancer Genomics: Leveraging Genomics for Precision Oncology
Author(s): JM Guidry Auvil, CW Barrett, TM Davidsen, ML Ferguson, P Gesuwan, NB Griner, Y He, S Jagu, CL Jones, JB Otridge, FL Pruitt, DS Gerhard
Replication stress shapes a protective chromatin environment across fragile genomic regions
Author(s): J Kim, D Sturgill, G Edwards, S Khurana, R Sebastian, A Tran, A Kruswick, S Burkett, Z Nayer, U Weyemi, W Bonner, K Luger, P Oberdoerffer
Whole-genome sequencing analysis of HPV31 and HPV35 reveals variability in cervical cancer risk
Author(s): M Pinheiro, Y Xiao, M Yeager, M Cullen, JF Boland, R Burk, Z Chen, K Yu, N Wentzensen, M Steinberg, S Bass, L Burdett, T Raine-Bennett, T Lorey, PE Castle, M Schiffman, L Mirabello
Xeroderma Pigmentosum in Brazil – defining clinical profile and mutational spectrum in an admixed population
Author(s): KM Santiago, LP Castro, SR Rogatto, JPD Neto, P Ashton-Prolla, PFV Medeiros, EM Ribeiro, BF Rodrigues, FF Valle, MJR Doriqui, CHB Leite, LMS Moura, V Munford, CFM Menck, MIW Achatz
Determining the Mechanism of Anti-Leukemic Drug Ro5-3335 Using an Inducible Leukemic Mouse Model
Author(s): EE Rapp, JL Diemer, PP Liu
Pro-fibrotic Phenotype of Human Hermansky-Pudlak Syndrome (HPS) Fibroblasts
Author(s): CH Han, T Yokoyama, BR Gochuico, MCV Malicdan, WA Gahl
The unusual skin microbiome of DOCK8-deficient patients
Author(s): O Tirosh, S Conlan, C Deming, C Ng, SQ Lee-Lin, NISC Comparative Sequencing Program, AF Freeman, HC Su, JA Segre, HH Kong
Towards a diagnostic panel for cancer detection and classification based on DNA methylation
Author(s): G Margolin, N Jameel, Y-C Chen, HM Petrykowska, L Elnitski
Validating coronary artery disease genetic findings using coronary artery calcification measures in Clinseq® cohorts
Author(s): Z Liu, H Sung, AF Wilson, LG Biesecker, NF Hansen, JC Mullikin
Exome sequencing of 103 Williams syndrome cases rules out variation in the remaining elastin allele and the larger Williams critical region as a major contributor to variance in blood pressure and arterial stenosis
Author(s): PCR Parrish, M Lugo, N Kopp, K Shields, YP Fu, RH Knutsen, M Pirooznia, BA Kozel
Genomic response of human immune and non-immune cells to glucocorticoids
Author(s): MR Gadkari, KN Howe, LM Franco, P Kumar, J Tsang, RN Germain
Identification of a novel mutation of RUNX2 in a family with cleidocranial dysplasia by whole-exome sequencing
Author(s): Dan Ma, Jun Zhang, Tao Cai, RD Leapman
KRAB-zinc finger proteins evolve to control mobile DNA elements and facilitate their adaptation as novel regulators of gene expression
Author(s): G Wolf, M Tinkham, D Hoang, A Mitra, A De Iaco, M Sun, T Macfarlan
A novel approach to genotype-phenotype profiling for ryanodine receptor 1-related myopathies
Author(s): MO Shelton, JW Witherspoon, C A, MS R, MX Cortes, IC Chrismer, Z Xuemin, KG Meilleur
Introducing RefSeq Functional Elements: A New Dataset Annotated by NCBI
Author(s): CM Farrell, T Goldfarb, SH Rangwala, KD Pruitt, TD Murphy, RefSeq Development Team
Dynamic Emergence of Pseudomonas aeruginosa Hypermutation and Ceftazidime-Avibactam Resistance in Acute Systemic Infection
Author(s): PP Khil, J Ho, J Youn, J Lemon, J Gea-Banacloche, KM Frank, RA Bonomo, JP Dekker
The importance of defining whole stool, sterile sampling methods and homogenization procedures for gut microbiome characterization
Author(s): SE Mudra, J Barb, K Schuebel, S Shim, S Klagholz, GR Wallen, NJ Ames
Affordable HPV testing for less developed countries
Author(s): EJ Torres-Gonzalez, MC Agudelo, M Rodriguez-Herrera, G Sanchez, M Dean
Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala
Author(s): MR Maria, H Lou, E Gharzouzi, SP Guerra, JF Domgue, J Sawitzke, G Villagran, L Garland, J Boland, S Wagner, J Martinez, H Rosas, J Troxler, H McMillen, B Kessing, E Alvirez, M Castillo, M Schiffman, R Orozco, M Dean
A single nucleotide polymorphism in an AP2 transcription factor encoded in the malaria-causing Plasmodium berghei alters the development of host immunity
Author(s): CK Cimperman, P Sheehan, M Akkaya, A Bansal, G Arora, A Molina-Cruz, CF Qi, M Pena
Advances in the Assessment of Plasmodium falciparum Pfs47 as a Transmission Blocking Target
Author(s): GE Canepa, A Molina-Cruz, L Douti, C Barillas-Mury
Antibiotic susceptibility of M. abscessus patients with long term antibiotic treatment
Author(s): S Daniel-Wayman, S Shallom, N Azeem, KN Olivier, A Zelazny, DR Prevots
Discovery of Novel Anti-Tuberculosis Drugs from Sphagnum Bog Bacteria
Author(s): M Espinoza-Moraga, HI Boshoff, CE Barry 3rd
Reducing the technical burden on publishing standardized metadata for microbiome studies
Author(s): M Quiñones, D Liou, C Shyu, L Kim, J Kehr, N Weber, D Hurt
A single nucleotide change in a functionally undefined region of the RRE impairs HIV replication through an RRE conformational switch
Author(s): C Sherpa, P Jackson, ML Hammarksjold, D Rekosh, S LeGrice
Dynamics of HIV clonal expansion and persistence during ART
Author(s): EM Anderson, S Hill, J Bell, FR Simonetti, C Rehm, S Jones, R Gorelick, M Kearney, J Coffin, F Maldarelli
Investigations into the Mechanism and Antiviral Activity of Thioester Inhibitors of HIV
Author(s): LM Jenkins, EL Paine, L Deshmukh, HD Tagad, DE Ott, E Appella, DH Appella
Both brain macrophages and memory CD4+ T-cells may serve as potential reservoirs in SIV-infected rhesus macaques
Author(s): CA Lee, E Beasley, K Sundar, K Matsuda, F Wu, CL Vinton, C Deleage, MG Smelkinson, JD Estes, JM Brenchley, VM Hirsch
Complementation of the role of the 68-kDa ankyrin-like protein of MVA by unrelated vaccinia virus proteins
Author(s): B Liu, D Panda, JD Mendez-Rios, LS Wyatt, B Moss
Examining the effect of producer cell-type on the target cell tropism of KSHV
Author(s): TD Maldonado, EA Brenner, SJ Dollery, EA Berger
Structural characterization of influenza virus-like particles displaying hemagglutinin have structural variances from native virus with potential for immunological impact
Author(s): DM McCraw, JR Gallagher, UM Torian, AK Harris
Technical Challenges of HIV Tat Protein Purification
Author(s): UA Santamaria, MM Bachani, JP Steiner, AL Popescu, W Li, A Nath
Poster Session III
Thursday, September 14, 2017 — 12:00 p.m. – 1:30 p.m. — FAES Terrace
Cutting edge photon counting CT facility at NIH: engaging extramural academic partners and promotion of cross disciplinary intramural team science
Author(s): EC Jones, P Sahbaee, WF Pritchard, AA Malayeri, A Samei, BJ Wood
Importance of Falx and Tentorium in Simulating Dynamic Deformations of Brain under Mild Angular Accelerations
Author(s): Y-C Lu, J Glaister, KT Ramesh, DL Pham, JL Prince, PV Bayly, NP Daphalapurkar
Cloud-based Homecage-Integrated Monitoring System to Improve Animal Care
Author(s): MA Garmendia, AV Kravitz, MA Ali, JU Dennis, CJ Foltz, GH Salem, JA Krynitsky, CA Roque, TJ Pohida
mHealth Smartphone Application to Measure Risky Driving Behavior and Predict Crashes
Author(s): RZ Freidlin, AD Dave, BG Espey, ST Stanley, MA Garmendia, CA Roque, TJ Pohida, JP Ehsani, BG Simons-Morton
Detection of Near Infrared Fluorescent Molecules by Flow Cytometry Enables Novel Applications in Vision Research
Author(s): RS Villasmil, JA Minehart, W Ma, A George, R Sharma, J Tam
Multimodal imaging of the retinal neurons and underlying epithelial cells in the living human eye using adaptive optics enhanced infrared autofluorescence
Author(s): T Liu, H Jung, J Liu, M Droettboom, J Tam
Biomedical Engineering and Physical Science (BEPS) Shared Resource
Author(s): HS Eden, EK Dimitriadis, AM Gorbach, HR Kalish, NY Morgan, G Zhang
Developing deep neural networks for automated 3D electron micrograph segmentation
Author(s): MD Guay, AB Anderson, ZA Emam, RD Leapman
Microfabricated structures for biomedical research
Author(s): NY Morgan, W Wulftange, M Villancio-Wolter
Quantitative Nailfold Video Capillaroscopy Parameters Correlate with Dermatomyositis Activity and Damage
Author(s): HK Prakash, D Song, D Lichy, P Rao, M Jain, J Shrader, FW Miller, A Schiffenbauer, A Gorbach, LG Rider
Sedimentation Velocity with Fluorescence Detection (SV-FDS) and its Applications to the Studies of Self- and Hetero-Associations of Ionotropic Glutamate Receptor Domains
Author(s): H ZHAO, S Lomash, C Glasser, S Chittori, M Mayer, P Schuck
A machine learning approach to determine functional biomarkers associated with psychopathic personality traits in a moral judgment task
Author(s): H Dashtestani, R Zaragoza, R Kermanian, F Chowdhry, AH Gandjbakhche
MAS-DNP NMR investigation of the transient intermediate state of melittin by the rapidly mixing and freezing technique
Author(s): J Jeon, KR Thurber, YM Yau, R Tycko
Micron-scale magnetic resonance imaging at very low temperatures
Author(s): HY Chen, E Moore, K Thurber, R Tycko
A Prospective Investigation of Coffee Drinking and Bladder Cancer Incidence in the United States
Author(s): E Loftfield, ND Freedman, M Innoue-Choi, BI Graubard, R Sinha
A prospective study of cancer risk associated with use of organochlorine insecticides among Agricultural Health Study farm spouses
Author(s): LM Louis, CC Lerro, MC Friesen, G Andreotti, S Koutros, D Sandler, A Blair, MG Robson, LE Beane Freeman
Association between circulating levels of sex steroid hormones and esophageal/gastric cardia adenocarcinoma
Author(s): JL Petrick, PL Hyland, P Caron, RT Falk, R Pfeiffer, SM Dawsey, CC Abnet, PR Taylor, SJ Weinstein, D Albanes, ND Freedman, G Bradwin, C Guillemette, PT Campbell, MB Cook
Association between pre-diagnostic circulating 25-hydroxyvitamin D and cancer survival
Author(s): SJ Weinstein, AM Mondul, K Yu, TM Layne, CC Abnet, ND Freedman, RZ Stolzenberg-Solomon, U LIm, MH Gail, D Albanes
Associations between duration of oral contraceptive use and ovarian, endometrial, breast, and colorectal cancers: modification by modifiable factors
Author(s): KA Michels, RM Pfeiffer, LA Brinton, B Trabert
Benign and Malignant Tumors in Patients Diagnosed with Myotonic Dystrophy Type 1
Author(s): R Alsaggaf, DM St George, RM Pfeiffer, Y Wang, M Zhan, KR Wagner, MH Greene, S Amr, SM Gadalla
Circulating ghrelin and gastric cancer in two cohorts in China
Author(s): N Pritchett, F Kamangar, SM Dawsey, JH Fan, B Ji, Y Gao, Y Qiao, HL Li, S Wang, FZ Stanczyk, W Chow, W Zheng, CC Abnet, ND Freedman, G Murphy
Circulating Inflammation Markers and Colorectal Cancer Risk: A Prospective Case-cohort Study in Japan
Author(s): M SONG, S SASAZUKI, MC CAMARGO, T SHIMAZU, TJ KEMP, RM PFEIFFER, A HILDESHEIM, LA PINTO, CS RABKIN, S TSUGANE
Development of the African Esophageal Cancer Consortium (AfrECC)
Author(s): SM Dawsey, G Murphy, N Pritchett, K Van Loon, B Kamila, C Mathew, M Mwachiro, V McCormack, S Gopal, CC Abnet
HIGHER SERUM SELENIUM CONCENTRATION IS ASSOCIATED WITH A HIGHER PREVALENCE OF ESOPHAGEAL SQUAMOUS DYSPLASIA IN BOMET, KENYA
Author(s): NR Pritchett, MM Mwachiro, SL Burgert, JD Brockman, CC Abnet, SM Dawsey
Intraprostatic cell cycle proteins in relation to the risk of prostate cancer recurrence
Author(s): MB Cook, SE Daugherty, P Lenz, LT Amundadottir, LR Sternberg, A Kibel, H Parikh, JN Sampson, SB Coburn, WY Huang, ND Freedman, A Black, SI Berndt, SM Hewitt, RN Hoover
Nut and peanut butter consumption and the risk of esophageal and gastric cancer subtypes
Author(s): M Hashemian, G Murphy, A Etemadi, SM Dawsey, LM Liao, CC Abnet
Serum caffeine metabolites along with cysteine, 2-oxoarginine, argininate, alpha-ketoglutarate, and chenodeoxycholate associated with glioma risk up to 26 years prior to diagnosis
Author(s): J Huang, SJ Weinstein, CM Kitahara, JN Sampson, D Albanes
Serum Metabolomic Profiling of All-Cause Mortality: A Prospective Analysis in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study Cohort
Author(s): J Huang, SJ Weinstein, SC Moore, A Derkach, X Hua, LM Liao, F Gu, AM Mondul, JN Sampson, D Albanes
Temporal variability of oral microbiota over 10 months and the implications for future epidemiologic studies
Author(s): E Vogtmann, X Hua, L Zhou, Y Wan, S Suman, B Zhu, C Dagnall, A Hutchinson, K Jones, B Hicks, R Sinha, J Shi, CC Abnet
Aortic Vascular Inflammation by FDG PET/CT is Associated with Coronary Non-Calcified Plaque in Psoriasis
Author(s): AD Belur, A Goyal, AA Joshi, AK Dey, JA Rodante, JH Chung, AA Sajja, YA Elnabawi, N Nanda, MP Playford, NN Mehta
Increased Amygdalar Activity is Associated with Aortic Vascular Inflammation Independent of Traditional Cardiovascular Risk Factors in Psoriasis
Author(s): A Goyal, AD Belur, A Chaturvedi, AK Dey, YA Elnabawi, AA Joshi, JA Rodante, A Sajja, N Nanda, MP Playford, NN Mehta
Positive association of serum sodium within the normal reference range of 135-145 mmol/l with cholesterol and blood pressure makes water a drug for prevention of cardiovascular diseases
Author(s): S Gao, X Cui, X Wang, MB Burg, NI Dmitrieva
Knee extension rate of force development and peak torque: associations with lower extremity function
Author(s): S Studenski, L Ferrucci
Plasma klotho, adiposity, and insulin resistance in older adults: findings from the InChianti Study
Author(s): MD Shardell, RR Kalyani, RD Semba, S Bandinelli, R Varadhan, L Ferrucci
Maternal polycystic ovarian syndrome and early offspring development: The Upstate KIDS Study
Author(s): GA Bell, R Sundaram, SL Mumford, HJ Park, MR Broadney, JL Mills, EM Bell, EH Yeung
Agreement Between Self-Reported and Objectively-Measured Sleep Duration among White, Black, Hispanic, and Chinese Adults in the United States: Multiethnic Study of Atherosclerosis
Author(s): CJ Jackson, SR Patel, B Jackson, PL Lutsey, S Redline
Circadian preference and insomnia differs between individuals with and without migraine in a nonclinical sample: results from the NIMH family study
Author(s): K Witonsky, L Cui, T Lateef, K Merikangas
Is the Startle Reflex a Potential Endophenotype for Anxiety Disorders?
Author(s): M Tsui, A Schmitz, A Van Meter, C Grillon, K Merikangas
Measuring Stability Across Multiple Domains of Mood and Affect
Author(s): Y Xiao, J Johns, KR Merikangas, V Zipunnikov
Quantifying systemic inflammation and its association with sagittal abdominal diameter in US adults
Author(s): A Amare, SH Jackson
Phenotype modelling tools utilizing standardized EHR data in a Common Data Model format
Author(s): RT Bhupatiraju, V Huser, KW Fung
Farnesoid X receptor protects against chemically-induced liver injury through the taurocholate-JNK pathway
Author(s): S Takahashi, N Tanaka, S Golla, T Fukami, KW Krausz, MA Polunas, BC Weig, Y Masuo, C Xie, C Jiang, FJ Gonzalez
FUBP1 and FUBP2: A “Buddy System” Essential for Cell Survival
Author(s): Y Zheng, R Bandle, W Dubois, HJ Chung, E Batchelor, D Levens
Glypican-3 Specific Antibody Drug Conjugate for Hepatocellular Carcinoma
Author(s): Y Fu, D Urban, R Nani, M Hall, M Schnermann, M Ho
Hsp90 of E. coli modulates assembly of FtsZ, the tubulin homolog in E. coli
Author(s): A Balasubramanian, M Markovski, S Wickner
Enzymatic and metabolic products of a distinct phospholipase in the retina: Towards the development of cell-based assays for a high-throughput screen
Author(s): JL Bullock, SP Becerra
High throughput RNAi screen identifies NOX4 – a druggable target to treat injury-induced eye degeneration and metastatic cancers
Author(s): KY Barbosa-Sabanero, J Chang, M Lal, K Bharti
PNPLA2 (Patatin-like Phospholipase Domain Containing Protein 2), a novel gene involved in lipid metabolism in the RPE
Author(s): F Polato, M Abu-Asab, SP Becerra
TNF-alpha mediates hepatic metabolic decompensation due to influenza in a mouse model of mitochondrial hepatopathy
Author(s): M Jestin, T Tarasenko, S Hwang, S Kapnick, P Zerfas, F Diaz, PJ McGuire
Understanding the Role of Oxidative Stress in Altering Cardiovascular Disease Severity in Williams Syndrome. A. Troia, R. Knutsen, J. Danback, B. Kozel; Laboratory of Vascular and Matrix Genetics
Author(s): A Troia, R Knutsen, J Danback, B Kozel
Mechanism of mast cell activation in patients with vibratory urticaria
Author(s): AN Naranjo, HD Komarow, SE Boyden, A Desai, MA Beaven, DD Metcalfe, A Olivera
Deletion of Prkar2a, with its exclusive habenular brain expression, confers obesity resistance through decreased hedonic drive and increased voluntary exercise
Author(s): E London, J Wester, CA Stratakis
Protective role of olesoxime in alpha-synuclein-induced mitochondrial dysfunction
Author(s): A Rovini, M Queralt-Martin, P Gurnev, T Rostovtseva, S Bezrukov
Beta-arrestin-1 is required for the proper function of pancreatic beta-cells and whole body glucose homeostasis
Author(s): LF Barella, M Rossi, L Zhu, J Wess
Role of Skeletal Muscle in Beta2-adrenergic Receptor Mediated Improvements in Whole Body Glucose Homeostasis
Author(s): J Meister, D Bone, R Lee, D Akhmedov, R Berdeaux, J Wess
The bacteriophage T4 MotB protein, a DNA binding protein, boosts the level of T4 late gene expression
Author(s): J Patterson-West, M Arroyo-Mendoza, L Iyer, D Hinton
Development and Validation of Cell-Based Assays in Quantitative High-throughput Formats for Identification of Acetylcholinesterase Inhibitors
Author(s): SZ Li, RH Huang, MF Santillo, MH Xia
Identification of acetylcholinesterase inhibitors using homogenous cell-based assays in quantitative high-throughput screening platforms
Author(s): SZ Li, RL Huang, S Solomon, YL Liu, Bin Zhao, MF Santillo, MH Xia
Brain mechanisms underlying chronic visceral pain and its association with affective behaviors in the absence of measurable pathology
Author(s): S Martinez Gonzalez, C Pichardo, Y Carrasquillo
Contribution of the central amygdala-zona incerta pathway in the modulation of persistent pathological pain
Author(s): LS Valdivia Torres, D Velasquez, S Arango, T Wilson, Y Carrasquillo
Genetic identification of ON/OFF cells in the central amygdala involved in the modulation of tactile hypersensitivity in a mouse model of neuropathic pain
Author(s): TD Wilson, H Ahn, S Valdiva-Torrres, A Khan, S Martinez Gonzalez, Y Carrasquillo
Postnatal development of lymphatoc vessels in the brain meninges
Author(s): RM Izen, Y Mukouyama
Uncovering molecular mechanisms of microcephaly
Author(s): T Schoborg, L Smith, S Smith, Y Yu, C Fagerstrom, T Lee, NM Rusan
GABAergic basal forebrain integrity is compromised in aged monkeys with cognitive impairment
Author(s): C Banuelos, KH Schulze, JR Kittleson, EJ Perez, JM Long, MT Roberts, S Fong, PR Rapp
Reliability of a Novel Video-Based Method for Assessing Age-Related Changes in Motoric Function
Author(s): D Pupo, J Kakareka, J Krynitsky, T Pohida, B Harvey, S Studenksi
Characterizing Patterns of Alcohol Consumption in High-Risk Drinkers Using A Pharmacokinetically-Controlled Human Laboratory Paradigm
Author(s): ME Sloan, JL Gowin, CD Ester, BL Stangl, J Stoddard, V Vatsalya, VA Ramchandani
Exogenous ghrelin administration affects alcohol self-administration and brain activity in heavy-drinking alcohol-dependent individuals: A human laboratory study
Author(s): M Farokhnia, EN Grodin, MR Lee, EN Oot, AN Blackburn, BL Stangl, ML Schwandt, LA Farinelli, R Momenan, VA Ramchandani, L Leggio
Gene network of dopamine receptor type 2 (Drd2) in addiction
Author(s): L Guerri, L Dobbs, A Meyers, A Badillo Martinez, V Alvarez, D Goldman
Ketosis restores hippocampal Krebs’ cycle intermediates and potentiates anxiolytic effects in a murine model of Alzheimer's disease
Author(s): RJ Pawlosky, Y Kashiwaya, MT King, RL Veech
Serotonergic modulation of the basal amygdala and fear learning
Author(s): A Sengupta, D Bannerman, M Capogna, T Sharp, A Holmes
Gene networks activated by specific patterns of action potentials in dorsal root ganglia neurons
Author(s): PR Lee, JE Cohen, DA Iacobas, S Iacobas, RD Fields
Motivated state transition requires somatostatin signaling and deep-brain photoreceptors
Author(s): EH Horstick, Y Bayleyen, J Sinclair, HA Burgess
PI4KA controls the levels of key lipids important for myelination in Schwann cells independently from the PI3K/Akt/mTOR pathway
Author(s): A ALVAREZ-PRATS, YJ KIM, T BALLA
Elucidating the role of the supramammillary nucleus in motivational processes
Author(s): AJ Kesner, S Ikemoto
Inhibitory Synapses onto Medial Olivocochlear Neurons in Ventral Nuclei of the Trapezoid Body are Glycinergic
Author(s): L Torres Cadenas, C Weisz
Abnormalities in neuronal and glial composition of hippocampal dentate gyrus in GNB5 heterozygous mice
Author(s): NG Lue, AM Awe, J Zhang, M Pandey, WF Simonds
Coordinated ramping of dorsal striatal pathways during motor planning
Author(s): TD London, I Szczot, J Licholai, W Fobbs, AV Kravitz
Knock out of β-arrestin-1 in AgRP neurons impairs whole body glucose metabolism
Author(s): Sai Pydi, Z Cui, DJ Oberlin, HE Egritag, M Chen, GJ Schwartz, C Buettner, J Wess
Cortical Thickness and Stressful Life Events in Anxious and Non-anxious Youths
Author(s): JF Sachs, D Pagliaccio, K Lewis, ER Steuber, J Pacheco, CA Filippi, E Leibenluft, DS Pine, AL Gold
Neural correlates of abstract social cognition in Williams syndrome and 7q11.23 Duplication syndrome
Author(s): DL Currin, TA Nash, M Jabbi, DP Eisenberg, MD Gregory, KV Roe, R Prabhakaran, J Carrasco, O Ravindranath, SE Grogans, MM O'Brien, JS Kippenhan, P Kohn, A Martin, CB Mervis, KF Berman
Single unit correlates of auditory oddball responses in the sensory, prefrontal, and amygdala regions of the macaque
Author(s): KC Scarim, CR Camalier, M Mishkin, BB Averbeck
The effect of a GABA receptor agonist on sleep deficiency in a Fragile X syndrome mouse model
Author(s): A Torossian, RM Saré, CB Smith
The effects of social awareness on anticipated social interactions in anxious and non-anxious youth: An fMRI study
Author(s): QB Do, BI Rappaport, EE Nelson, JM Jarcho, DS Pine, AR Smith
White matter microarchitecture in children with 7q11.23 duplication syndrome
Author(s): SE Grogans, TA Nash, O Ravindranath, MM O'Brien, DL Currin, JS Kippenhan, P Kohn, DP Eisenberg, MD Gregory, CB Mervis, KF Berman
The ups and downs of analyzing cortico-cortical connectivity with TMS-EEG
Author(s): JA Reeves, C Altany, MV Freedberg, EM Wassermann
Poster Session IV
Friday, September 15, 2017 — 1:00 p.m. – 2:30 p.m. — FAES Terrace
Regulation of FLT3LG and MCL1 by miR-424 and miR-181c in GATA2 Deficiency
Author(s): SH Droll, W Wang, Z Zhao, AP Hsu, SM Holland, KR Calvo
A high-throughput screen of an annotated small molecule library identifies substrates of P-glycoprotein
Author(s): TD Lee, OW Lee, C Cardarelli, KR Brimacombe, MM Gottesman, M Shen, MD Hall, L Chen, R Guha
A single cell view of MYC's gene regulatory and oncogenic mechanism
Author(s): S Patange, M Girvan, D Levens, DR Larson
Mechanistic Investigation of DRD1 and EGFR as a Novel Signaling Axis in Lung Cancer
Author(s): LB Toulabi, K Lee, A Zingone, BM Ryan
MiR130a and miR145 reprogram immature myeloid cells and inhibit tumor metastasis via improvement of anti-tumor immunity
Author(s): H Ishii, SK Suman, BR Achyut, MC Hollander, A Lal, L Yang
Nano-proteomic analysis technologies: advancing quantitative proteomic research, biomarker assessment, and molecular profiling
Author(s): J Chen, X Luo
NITRIC OXIDE-MEDIATED KYNURENINE/AHR SIGNALING ENHANCES DISEASE PROGRESSION IN PANCREATIC CANCER
Author(s): L Wang, S Yang, P He, SP Hussain
Real-time endoscopic fluorescent imaging with IR700 signal for monitoring the therapeutic effects of near infrared photoimmunotherapy
Author(s): T Nagaya, Y Nakamura, K Sato, S Okuyama, F Ogata, P Choyke, H Kobayashi
STAT1 dependent interferon-related DNA damage resistance signature (IRDS) is a survival mechanism in castrate resistant prostate cancer (CRPC)
Author(s): S AGARWAL, K McGowen, K Kelly
Systematic review examining the use of Ablative Therapies for DCIS and Early Stage Breast Cancer
Author(s): AV Rao, M Mullooly, BM Heckman- Stoddard, ME Sherman
Therapeutically targeting glypican-2 via single domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma
Author(s): N Li, HY Fu, S Hewitt, DS Dimitrov, M Ho
Thymic Precursor Cells Generate Acute Myeloid Leukemia in NP23-NHD13 Double Transgenic Mice
Author(s): S Kundu, E Park, YJ Chung, T Barlowe, PD Aplan
TWEAK-FN14 Pathway Promotes Prostate Cancer Bone and Brain Metastasis through EGR1-mediated Angiogenesis
Author(s): L Li, AH Ameri, J Yin, S Wang, KH Jansson, ML Beshiri, L Fang, R Lake, S Agarwal, AN Alilin, K Kelly
Detecting DNA methylation in non-invasive patient samples for cancer diagnostics
Author(s): BF Miller, TR Pisanic, HM Petrykowska, G Margolin, L Elnitski
Development of a pan-cancer DNA methylation biomarker
Author(s): N Jameel, H Petrykowska, G Margolin, B Miller, L Elnitski
CD38 knockout suppresses tumorigenesis in mice and clonogenic growth of human lung cancer cells
Author(s): X Bu, J Kato, JA Hong, MJ Merino, DS Schrump, FE Lund, J Moss
Divergent effects of wild-type and mutant p53 in the induction of NOX4 during cancer progression: a bioinformatics approach
Author(s): WF Ma, HE Boudreau, TL Leto
The D816V-KIT mutation causes IL-6 upregulation in human mast cells
Author(s): A Tobío, P Hanjra, G Bandara, HD Komarow, MC Carter, D Cantave, DD Metcalfe, A Olivera
LTβ/LTβ receptor mediates alternative NF-κB activation through NIK and RELB/NF-B2 to promote cell migration of HNSCC
Author(s): R Das, J Coupar, A Saleh, P Clavijo, Z Chen, C VanWaes
Modulation of death pathways by TRAILR2 agonist antibody in HPV-positive head and neck squamous cell carcinomas
Author(s): Y An, L Sun, A Derakhshan, S Carlson, R Das, Z Chen, C Van Waes
Novel repurposing of propranolol as an anti-tumor agent in glioblastoma
Author(s): MJ Shepard, A Bugarini, Q Zhang, Z Zhuang, P Chittiboina
Preclinical Evaluation of Therapeutic Compounds in Mouse Models for Cancer at the Center for Advanced Preclinical Research (CAPR)
Author(s): Ludmila Szabova, Rajaa El Meskini, Tomas Vilimas, Baktiar Karim, Stephen Jones, Shyam Sharan, Serguei Kozlov, Zoe Weaver Ohler
A Random Forest Model for Detecting Somatic Mutations from Unpaired Cancer Samples
Author(s): S Tu, B Zhou, DW Huang, R Schmitz, GW Wright, LM Staudt, CA Johnson
A high-throughput imaging assay for studying gene expression dynamics in live single cells
Author(s): PR Gudla, G Zaki, Y Wan, D Stavreva, G Pegoraro, D Larson, G Hager
Automated Workflow For Processing, Distributing and Archiving of Raw Next Generation Sequence Data
Author(s): CE McIntosh, V Bliskovsky, EA Conner, PC FitzGerald
Phosphorylated Calmodulin Promotes PI3K Activation by Binding its SH2 Domains
Author(s): Min Zhang, Hyu Jang, Rut Nussinov
Prediction of novel host-pathogen interactions for Helicobacter pylori through interface mimicry and their implications to gastric cancer
Author(s): E Guven Maiorov, CJ Tsai, B Ma, R Nussinov
Differentiating between sequence and methylation variability in genome methylation data
Author(s): BA LaBarre, VM Hayes, LL Elnitski
Finding possible missed variant candidates through coverage comparison among varying sequencing technologies
Author(s): HB Fauni, CJ Adams, K Chao, T Ten, C Lau, B Pusey, D Adams, W Gahl
Get more out of your Markov clusters: leveraging dynamic parameter selection and recursion for fine-grained orthogroup classification
Author(s): SR Bond, AD Baxevanis
Significant associations between driver gene mutations and DNA methylation alterations across many cancer types
Author(s): Y Chen, V Gotea, G Margolin, L Elnitski
Somatic mutations induced by UV radiation contribute to melanoma through affecting gene splicing
Author(s): V Gotea, Y Samuels, J Mullikin, L Elnitski
Mass mining: a crowdsourcing approach for meta-analyzing gene expression signatures of autoimmunity using large-scale public data sets
Author(s): R Sparks, WW Lau, OJ Working Group, JS Tsang
Molecular spelunking: exploration of biological structures in a virtual reality environment
Author(s): J Tyrwhitt-Drake, P Cruz, M McCarthy, D Hurt
NIAID Clinical Genomics Tools
Author(s): A Oler, S Xirasagar, Z Li, K Huang, D Veltri, D Kaminsky, M Simuluk, Y Zhang, J Johnson, C Hong, J Milner
Reliability of OGTT Parameters in Obese Teenagers at Risk For Type 2 Diabetes
Author(s): AU Onuzuruike, S Kunnam, K Kasturi, JA Yanovski, ST Chung
Analysis of HT-SELEX data implicates the role of DNA shape readout in non-specific binding of Transcription Factors
Author(s): S Pal, T Przytycka
AptaTRACE – Elucidation of RNA Sequence-Structure Motifs from Selection Trends in HT-SELEX Experiments
Author(s): P Dao, J Hoinka, M Takahashi, J Zhou, M Ho, Y Wang, F Costa, JJ Rossi, R Backofen, J Burnett, TM Przytycka
Magic-BLAST: a new DNA and RNA-seq mapping tool
Author(s): GM Boratyn, J Thierry-Mieg, D Thierry-Mieg, B Busby, TL Madden
NetREX: Network Rewiring using EXpression - Towards Context Specifc Regulatory Networks
Author(s): Y Wang, D Cho, H Lee, J Fear, B Oliver, T Przytycka
Origin and evolution of tracrRNA in CRISPR systems
Author(s): G Faure, S Shmakov, KS Makarova, YO Wolf, EV Koonin
Predicting drug–drug interactions through drug structural similarities and interaction networks incorporating pharmacokinetics and pharmacodynamics knowledge
Author(s): T Takeda, M Hao, T Cheng, SH Bryant, Y Wang
PSST: A tool for detecting multiple SNPs in NGS datasets
Author(s): A Vohra, S La, C Mashayamombe, E Marte, D Thompson, B Busby
SPARCLE: Functional characterization of proteins by domain architecture
Author(s): RA Yamashita, A Marchler-Bauer, L Han, J He, C Lanczycki, S Lu, Y Bo, F Chitsaz, M Derbyshire, R Geer, N Gonzales, M Gwadz, D Hurwitz, F Lu, G Marchler, J Song, N Thanki, D Zhang, C Zheng, L Geer
The effect of late diagnosis on women with turner syndrome
Author(s): GE Reimann, LE Comis, M Bernad-Perman
Detection of novel lung cancer mutational signatures in African Americans
Author(s): N Nichols, KA Mitchell, J Waterfall, D Edelman, A Zingone, E Bowman, P Meltzer, BM Ryan
Inflammatory-based racial differences in lung cancer biology: diagnostic and prognostic implications
Author(s): CL Meaney, KA Mitchell, A Zingone, DA Brown
Vitamin D and prostate cancer risk in black men
Author(s): TM Layne, SJ Weinstein, X Ma, BI Graubard, ST Mayne, D Albanes
Temporal proteomic analysis of acute Dextran Sulfate Sodium-induced colitis
Author(s): N Schneider, SR Burks, AH Paz, JA Frank
Effect of calcium carbonate encapsulation on the activity of orally administered CpG oligonucleotides
Author(s): N Kayraklioglu, J Scheiermann, WG Alvord, DM Klinman
Encapsulating K- and D-type CpG ODNs within liposomes enhances and broadens their as vaccine adjuvants
Author(s): BH Horuluoglu, I Gursel, DM Klinman
Toll-like receptor 2/1 signaling induces human monocytes to differentiate into immunosuppressive macrophage: implications for the treatment of autoimmune and inflammatory diseases
Author(s): D Bayik, D Tross, LA Haile, L Rider, D Verthelyi, DM Klinman
High Resolution Flow Cytometry Analysis of Activated T Cells
Author(s): JA Minehart, RS Villasmil, B Xu
Interleukin 37 negatively associates with coronary plaque burden in psoriasis
Author(s): CL Harrington, AK Dey, Y Baumer, AD Belur, YA Elnbawi, A Goyal, Q Ng, A Sajja, GE Sanda, AV Sorokin, HL Teague, NJ Varghese, MP Playford, NN Mehta
Low-Density Granulocytes Associate with Non-Calcified Coronary Plaque and Endothelial Damage in Psoriasis
Author(s): NJ Varghese, HL Teague, AK Dey, A Joshi, Y Baumer, PK Dagur, CL Harrington, GE Sanda, AD Belur, A Goyal, YA Elnabawi, AV Sorokin, DA Bluemke, M Chen, MP Playford, JP McCoy, Jr, MJ Kaplan, NN Mehta
Psoriasis-induced acceleration of atherogenesis: a novel murine mouse model
Author(s): GE Sanda, Y Baumer, Q Ng, AK Dey, HL Teague, AV Sorokin, PK Dakur, JI Silverman, CL Harrington, JA Rodante, DA Springer, CK Bleck, CL Thomas, ZX Yu, MC Winge, HS Kruth, MP Marinkovich, AA Joshi, MP Playford, NN Mehta
The platelet NLRP3 inflammasome is upregulated in sickle cell disease patients
Author(s): T Arora, X Wang, SL Thein, S Vogel
A platform design for long-term high-resolution imaging of T lymphocyte-APC interactions in health and aging
Author(s): S Chakraborty, B Dura, J Voldman, MH Sung
A role for S1P4 receptor expression in the modulation of immune responses and mast cell function
Author(s): JM Kulinski, A Olivera, DD Metcalfe
Dynamic insight into naive lymphocyte extravasation in vivo
Author(s): SL Yan, O Kamenyeva, IY Hwang, JH Kehrl
Interplay of different TLR signaling pathways and the affect of simultaneous stimulation of TLR and BCR on B lymphocyte activation
Author(s): BP Theall, TA Henke, SK Pierce, M Akkaya
The LPS-responsive ADP-ribosylated proteome
Author(s): CM Daniels, AG Nuccio, A Nita-Lazar
Biomarker Detection Using MALDI Imaging
Author(s): M Davisson, G Fabozzi, C Petrovas, H Kalish
The role of LAP in T cell-mediated contact dermatitis
Author(s): J Suwanpradid, T Oguin, J Kolb, A Macleod, J Martinez
Distinct Myeloid Cell Subsets Promote Angiogenesis and Damaged Tissue Clearance Following Mild Traumatic Brain Injury
Author(s): MV Russo, DB McGavern
Roles of Parkin and PINK1 in muscle damage and inflammation following exercise
Author(s): DA Sliter, J Martinez, RJ Youle
NLM3D: an open-source library of medical-imaging-derived 3D polygonal models for use in public health, medical and STEM applications
Author(s): KM Browne, AR Altemus
Preclinical pharmacokinetic of a lead peptide for bronchopulmonary dysplasia prevention
Author(s): KM Konrath, MD Singleton, AQ Wang, X Xu
Validation of an Extended Metabolic Stability Assay Using Human Liver Subcellular Fractions
Author(s): M Kabir, P Shah, X Xu
Application of positron emission tomography (PET) for the study of the pharmacokinetics of albumin-binding radioligands in mice
Author(s): DO Kiesewetter, O Jacobson, R Tian, Z Wang, G Niu, X Chen
Baseline leptin cutpoints predictive of metreleptin response by RIA and ELISA assays in patients with lipodystrophy
Author(s): N Malandrino, B Abel, S Auh, M Walter, M Startzell, E Cochran, P Gorden, RJ Brown
Thyroid hormone effects on lipid panel based on NMR LipoProfile 4 in patients with insulin receptor mutations
Author(s): PD Kothari, Y Kushchayeva, M Startzell, E Cochran, R Shamburek, T Lin, P Gorden, RJ Brown
Changes in stress-responsive gene expression in a panel of human embryonic stem cells following ultra low dose diagnostic CT scan procedures
Author(s): MV Sokolov, R Maass-Moreno, RD Neumann
Modeling the hematopoietic defects of Familial Platelet Disorder with patient-specific induced pluripotent stem cells
Author(s): DW McKellar, EM Kwon, PP Liu
Eltrombopag Promotes DNA Repair in Human Hematopoietic Stem and Progenitor Cells: Implications for the Treatment of Fanconi Anemia
Author(s): KL Guenther, PS Cheruku, RH Smith, A Larochelle
Soluble Amyloid Precursor Protein (sAPP) functions as a vascular niche signal that controls adult neural stem cell number
Author(s): Y Sato, Y Uchida, YS Mukouyama