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NIH Research Festival

September 13 – 15, 2017

Tocopherol enters cell through the endocytic pathway and regulates lysosomal exocytosis

Wednesday, September 13, 2017 – Poster Session I
12:00 – 1:30 p.m.

FAES Terrace

NCATS

CELLBIO-2

Authors

  • M Xu
  • ZD Shi
  • S Titus
  • BY Xu
  • RE Swenson
  • W Zheng

Abstract

Our previous data showed that alpha- and delta-tocopherols reduce lysosomal cholesterol accumulation in patient cells derived from Niemann-Pick disease type C (NPC). However, the molecular target and precise mechanism of action for tocopherols are still unclear. It was reported that tocopherols might enter cells by inserting its phytyl tail into the plasma membrane. We have synthesized a Cy3 dye-labeled delta-tocopherol (CY3-DT) analog that preserves the cholesterol reduction property of delta-tocopherol. We found that the Cy3-DT entered cells through a endocytic pathway and exhibited a punctuate pattern that reached a steady state in 8 hours and the fluorescence remained in cells over 24 hours. Cy3-DT distributed in the highest levels in lysosomes (29%), late endosomes (16%), and early endosomes (11%).

Scientific Focus Area: Cell Biology

This page was last updated on Friday, March 26, 2021

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Current Research Festival

  • 2025
  • 2024
    • General Schedule of Events
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    • Special Wednesday Events
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  • 2023
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    • NIH Early–Career Investigator Lectures
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • Vendor Exhibit Information
    • Research Festival Committee
  • 2021
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    • General Schedule of Events
    • Plenary Sessions
    • Poster Session
    • Data Blitz
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committee
  • 2018
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    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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    • Concurrent Symposia Sessions
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    • Future Research Leaders
    • Special Exhibits on Resources for Intramural Research
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