Poster Sessions
Poster Session I
Wednesday, September 12, 2018 — 12:00 p.m. – 1:30 p.m. — FAES Terrace
Acute alcohol exposure decreases circulating anandamide levels in humans
Author(s): CW Grant, ME Sloan, R Cinar, BL Stangl, TD Klepp, HW Brewton, N DiazGranados, G Kunos, VA Ramchandani
Predicting Parent Report of Executive Functioning in 36-Month-Old Toddlers with Parent Reported Communication Capabilities
Author(s): JD Harrison, C Farmer, A Thurm
Disentangling Fatigue from Anhedonia: a systematic review
Author(s): SC Kumar, RR Billones, LN Saligan
Predicting Pathways to Aggression in Youth with Disruptive Mood Dysregulation Disorder
Author(s): SC Perlstein, E Cardinale, N Gancz, L Wakschlag, MJ Briggs-Gowan, K Towbin, DS Pine, MA Brotman, E Leibenluft
Childhood Social Reticence and Early Adolescent Anxiety
Author(s): DA Phillips, AR Subar, K Seddio, GA Buzzell, NA Fox, DS Pine, A Harrewijn, C Filippi
Compact video monitoring systems for large-scale mouse ethology
Author(s): G Salem, J Krynitsky, M Garmendia, Y Pederson, AV Kravitz, A Pu, JU Dennis, JB Mitchell, T Pohida
Video Analysis System for Behavior and Activity Assessment of Fruit Flies in High-Throughput Studies
Author(s): G Salem, J Krynitsky, M Garmendia, Y Pederson, S Harbison, M Jaime, B Oliver, T Pohida
Complexity of multidisciplinary norms in collaborative teams; epistemic diversity in authorship distribution ethics
Author(s): EM Smith, B Williams-Jones, Z Master, V Larivière, CR Sugimoto, A Paul-Hus, M Shi, DB Resnik
Racial Residential Segregation and Racial Disparities in Stillbirth in the United States
Author(s): AD Williams, ME Wallace, CJ Nobles, P Mendola
Keeping it together: the role of FGF signaling in embryonic ventral wall closure
Author(s): M Boylan, M Anderson, I Hung, D Ornitz, M Lewandoski
Keeping it together: the role of FGF signaling in embryonic ventral wall closure
Author(s): MGS Boylan, M Anderson, I Hung, D Ornitz, M Lewandoski
High resolution imaging to study sympathetic nervous system patterning
Author(s): NG Burns, W Li, Y Mukouyama
Single Cell Transcriptome Analysis Reveals Pancreatic Hormone Lineage Decisions
Author(s): E Duvall, C Benitez, M Enge
In Vivo Spontaneous Calcium Activity Imaging of Zebrafish Hair Cells
Author(s): OA Hamdi, Q Zhang, A Beirl, K Kindt
Brd4 binds to active enhancers to control cell differentiation and tissue development
Author(s): JE Lee, YK Park, A Dey, K Ozato, W Peng, G Kai
Sonic hedgehog is required for the formation of auditory ganglion in the mouse inner ear
Author(s): LS Wong, DK Wu
Familial Risk for Bipolar Disorder is Associated With Decreased Neurocognitive Performance in Unaffected Relatives: A Preliminary Report from the Amish-Mennonite Bipolar Genetics (AMBiGen) Project
Author(s): EK Besançon, F Lopes, L Wille, M Mallmann, L Kassem, FJ McMahon
Structural Differences Between Pri-miRNA Paralogs Promotes Alternative Drosha Cleavage and Expands Target Repertoires
Author(s): X Bofill-De Ros, WK Kasprzak, Y Bhandari, L Fan, Q Cavanaugh, M Jiang, L Dai, A Yang, TJ Shao, BA Shapiro, YX Wang, S Gu
Investigating Determinants of Visual Outcome in Foveal Hypoplasia
Author(s): KD Bordonada, LA Huryn, WM Zein, BP Brooks, RB Hufnagel
Epigenomic reconfiguration during aging of rod photoreceptors reveals a crosstalk between DNA methylation and stress pathways
Author(s): X Corso-Diaz, R Rebernick, C Jaeger, F van Asten, A Swaroop
A loss-of-function mutation in RHBDF2 causes defects in TACE activity and immunodeficiency
Author(s): JM Fritz, HM Raquer, J Zou, X Jing, MJ Lenardo
Opportunistic screening of RYR1 variants for MHS
Author(s): SG Gonsalves, JJ Johnston, D NG, LG Biesecker
Gene network of dopamine receptor type 2 (Drd2) in addiction
Author(s): L Guerri, L Bobbs, A Meyers, V Alvarez, D Goldman
Telomeres in Hermansky-Pudlak Syndrome pulmonary fibrosis
Author(s): C Han, H Dorward, T Franklin, KJ O'Brien, WA Gal, MCV Malicdan, BR Gochuico
TB Portals Genomic Analysis Portal (G-AP): a genomic data exploration platform for translational research
Author(s): M Harris, J Yu, K Wollenberg, A Gabrielian, E Engle, J Taaffe, D Hurt, A Rosenthal, A Tartakovsky
Genetic model of MS severity (GeM-MSS) predicts future accumulation of disability
Author(s): KC Jackson, K Sun, C Barbour, JL Milstein, JT Phillips, P Kosa, B Bielekova
Mutation in retinoic acid receptor β DNA binding domain affects nuclear localization and transcriptional activity causing ocular coloboma
Author(s): VK Kalaskar, RP Alur, LK Li, Y Sergeev, T Cogliati, BP Brooks
Somatic activating mutations in MAP2K1 cause melorheostosis
Author(s): H Kang, S Jha, Z Deng, N Fratzl-Zelman, WA Cabral, A Ivovic, F Meylan, EP Hanson, E Lange, J Katz, P Roschger, K Klaushofer, EW Cowen, RM Siegel, JC Marini, T Bhattacharyya
Mixed Phenotype Acute Leukemia in Xeroderma Pigmentosum Patient with XPC Founder Mutation
Author(s): SG Khan, MA Levoska, D Tamura, S Ito, KR Calvo, K Oetjen, KH Kraemer, JJ DiGiovanna
Variation in human chromosome 21 ribosomal RNA genes characterized by TAR cloning and long-read sequencing
Author(s): J Kim, AT Dilthey, R Nagaraja, H Lee, S Koren, D Dudekula, WH Wood III, Y Piao, AY Ogurtsov, K Utani, VN Noskov, SA Shabalina, D Schlessinger, AD Phillippy, V Larionov
Engineering the mouse genome using Cas9-APOBEC base editing
Author(s): HK Lee, MW Willi, C Liu, L Hennighuasen
Large genomic deletions in Shwachman-Diamond syndrome
Author(s): LJ McReynolds, K Jones, K Teshome, A Kennedy, A Shimamura, N Giri, BP Alter, SA Savage
Lysosomal storage, neurodegeneration, and albinism due to effects of a de novo CLCN7 mutation on lysosomal acidification
Author(s): E-R Nicoli, MR Weston, ME Hackbarth, AJ Becerril, A Larson, JD Burke, H Dorward, Y Huang, DR Adams, PM Zerfas, TC Markello, C Toro, G Elliot, L Garett, W Zheng, CJ Tifft, WA Gahl, DL Day‐Salvatore, JA Mindell, MCV Malicdan
Dual roles for yeast Sti1/Hop in regulating the Hsp90 chaperone cycle
Author(s): M Reidy, S Kumar, DE Anderson, DC Masison
Mutational analysis of late-stage endometrioid endometrial carcinoma exomes
Author(s): ML Rudd, X Zhang, NF Hansen, NISC Comparative Sequencing Program, S Zhang, MJ Merino, JC Mullikin, DW Bell
Exome sequencing and functional studies in human neurodevelopmental disorders: novel genes and phenotypes
Author(s): J Stephen, C Rivas, S Nampoothiri, A Elkahloun, JD Burke, UDN Network, S Maddirevula, AB Kulkarni, A Shukla, HD Morris, SJ Patil, A Rauch, P Joset, JA Martinez-Agosto, LJ Garrett, FS Alkuraya, T Yokoyama, WA Gahl, N Balanda, MCV Malicdan
Endogenous retroviruses facilitate lineage-specific evolution of human placental gene expression landscape
Author(s): M Sun, G Wolf, C Dunn-Fletcher, L Muglia, T Macfarlan
Elucidating enhancers governing human pancreatic cell identity and function
Author(s): L Wang, J Wildenthal, T Truongvo, M Erdos, H Efsun Arda
A Direct Comparison of the Neurodevelopmental Profiles of a PMM2-CDG Cohort and NGLY1-CDDG Cohort
Author(s): TE Weixel, O Adedipe, CR Ferreira, WA Gahl, A Thurm, LA Wolfe
Whole genome sequencing unveils that the frequency of spurious mutations is not substantially increased by CRISPR-Cas9 genome editing
Author(s): M Willi, HE Smith, C Wang, C Liu, L Hennighausen
Maternal factors associated with DNA methylation-based placental aging
Author(s): T Workalemahu, D Shrestha, SM Tajuddin, F Tekola-Ayele
Characterization of miR-153 knockout and miR-153 transgenic mice: An initial analysis of its target genes in the brain and pancreas islets
Author(s): HX ZHANG, JJ XIONG, GN CARMONA, A CHO, T CAI, AL NOTKINS
Effects of FBXW7 mutations in serous endometrial cancers: increased levels of potentially druggable proteins and in vitro sensitivity to SI-2 and dinaciclib
Author(s): ME Urick, DW Bell
Misrouted Case Report Forms (CRFs) Outline in DataFax
Author(s): F Appiah, N Moodley, M Holdsworth, C Lassnoff, S Debrincat, J Singh, C Whalen, M Tartakovsky
A Tandem Chromatography Approach to Determine Titer for In-Process Production of Recombinant Tetanus Toxoid Fragment C
Author(s): N Barefoot, Y Yang, A Vinitsky, T Cozine, P Lei
Characterization of protease inhibitor conjugated CAP256-VRC26.25 impurities
Author(s): XC Cai, NA Schneck, VB Ivleva, W Zhao, D Blackstock, FJ Arnold, JW Cooper, QP Lei
Breaking down OHRP Assurance
Author(s): RY Cox, LB Hoopengardner, E Annum, SM Simpson, S Vogel, J Pierson, B Baseler
NIH programs to support early career scientists in biomedical research
Author(s): R DelCarmen-Wiggins, KJ Serrano, E Gorodetsky, VA Cargill
Development and automation of primary outcome data visualizations and reports
Author(s): MJ Duvenhage, J Wang, C Ying, F Appiah, S Debrincat, K Arora, D Armstrong, L Via, C Whalen, CE Barry 3rd, L Dodd
2018 careers for NIH scientists in technology transfer & business development
Author(s): SM Ferguson, JW Thomas
NIH scientists and the Federal Laboratory Consortium for Technology Transfer (FLC) in 2018
Author(s): AZ Amar, SM Ferguson, JE Pevenstein
Considering sex as a biological variable (SABV) in research: a primer for intramural investigators
Author(s): E Gorodetsky, KJ Serrano, VA Cargill
Developing an interactive visualization tool for exploration and analysis of laboratory data: Study Data Browser
Author(s): HM Hall, SW Bartlinski, GK Ha, T Ahmed, S Xu, KJ Footer, BB Smith, JW Croghan, A Rosenthal, DB Parrish
Sample Processing and Immunologic Testing Support Services Provided by the Clinical Support Laboratory
Author(s): JR Inglefield, M Baseler
A Survey on Including Risks in the New “Key Information” Section of an Informed Consent Form: Where Do We Go from Here?
Author(s): KW Le, SL Kopka, DG Chaitt, JF Pierson, MC Nason, TJ Miller
The NIAID Biovisualization Lab: a pilot program to provide virtual/augmented reality technology for biomedical research
Author(s): MC McCarthy, P Cruz, K Zhang, V Starr Kramer, DE Hurt
Biomedical Engineering and Physical Science Shared Resource
Author(s): NY Morgan, E Dimitriadis, H Kalish, M Bollard, G Zhang
FDA’s Post Marketing Requirements of Approved Drugs Is A Major Step to Enhance Drug Safety and Public Health
Author(s): P Panneerselvam, f Provorny, S Ferguson
Development of a RPLC-UV method for monitoring uncleaved HIV-1 envelop glycoprotein
Author(s): NA Schneck, AL Vinitsky, VB Ivleva, FJ Arnold, JW Cooper, QP Lei
Sex and gender in health and disease scientific interest group
Author(s): KJ Serrano, E Gorodetsky, VA Cargill
Human Research Protection Program (HRPP) Coverage for Investigators Working on National Institute of Mental Health (NIMH) Protocols at the National Institutes Health
Author(s): CB Servis, A Evans, J Radcliffe, S Rojas
The Advanced Imaging and Microscopy (AIM) Resource
Author(s): HD Vishwasrao, J Chen, H Shroff
Quality Control For A CDISC+SDTM Based Clinical Data Warehouse
Author(s): G Wei, J Xiao, KK Bajwa, SK Debrincat, C Whalen, M Tartakovsky
N-glycosylation Type and Structure Analysis of HIV-1 Trimer 4571 and HIV-1 Broadly Neutralizing Antibodies (bNAbs) by Tandem Exoglycosidase Digestion
Author(s): Y Yang, F Arnold, J Cooper, P Lei
CATALYST Program: Bridging the gap between breakthrough innovation and commercialization
Author(s): D Basudhar
Poster Session II
Wednesday, September 12, 2018 — 3:30 p.m. – 5:00 p.m. — FAES Terrace
Nuclear pore complex protein, Nup210 is a novel mediator of metastasis in breast cancer
Author(s): R Amin, A Shukla, S Kim, J Zhu, Y Ruan, G Hager, K Hunter
Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations
Author(s): E An, P Torres-Ayuso, J Brognard
Sequential expression of lineage specific SOX factors drives differentiation in High-Risk Neuroblastoma
Author(s): D Banerjee, BE Gryder, Z Liu, S Bagchi, HC Chou, S Sindiri, J Khan, CJ Thiele
NCI Office of Cancer Genomics: Advancing precision oncology through large-scale genomic, functional, and translational research programs
Author(s): PC Birriel, CW Barrett, TM Davidsen, ML Ferguson, P Gesuwan, NB Griner, Y He, S Jagu, DS Gerhard
CRISPR guide multiplexing to explore RNA binding Protein Families
Author(s): Q Brail, A Schmiechan, P Batista
Characterization of Fumarate Hydratase Enzyme Expression and Activity in Clinically Positive but Genetically Undefined Hereditary Leiomyomatosis and Renal Cell Carcinoma Patients
Author(s): GM Cawthon, DR Crooks, L Middleton, CJ Ricketts, CD Vocke, RA Worrell, WM Linehan
Proteomic Analysis Technologies: Advancing Quantitative Proteomic Research, Biomarker Assessment, and Molecular Profiling
Author(s): J CHEN, K NOEMI, X LUO
Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor Roquin2
Author(s): J Choi, K Lee, K Ingvarsdottir, R Bonasio, A Saraf, L Florens, MP Washburn, S Tadros, MR Green, L Busino
Tumor suppressive role of CRL3-KLHL6 in Diffuse Large B-cell Lymphoma
Author(s): J Choi, K Lee, K Ingvarsdottir, R Bonasio, A Saraf, L Florens, MP Washburn, S Tadros, MR Green, L Busino
Transcriptomic and proteomics analysis of murine breast and melanoma tumor models following pulsed focused ultrasound
Author(s): G Cohen, R Lorsung, S Burks, JA Frank
Transcriptomic and proteomics analysis of murine breast and melanoma tumor models following pulsed focused ultrasound
Author(s): G Cohen, R Lorsung, S Burks, JA Frank
NIEHS/NTP Mouse Aging Study: Strain dependent differential cancer susceptibility
Author(s): J Dunnick, R Herbert, K Janardhan, K Shockley, A Pandiri, A Merrick
A model of proteasome inhibitor resistance driven by metabolic reprogramming
Author(s): SM Gaikwad, A Michalowski, AS Quintanilla, A Zingone, S Najera, J Simmons, N Watson, M Lal, E Buehler, S Gorjifard, TJ Peat, BA Mock
Role of whole genome duplication in chromosomal instability
Author(s): O Gonul Geyik, D Wangsa, Z Yuce, T Ried
Oxygen tension regulates lysosomal proteolysis and RTK level in cancer through mTOR-TFEB-V-ATPase pathway
Author(s): J Hong, TR Wuest, Y Min, PC Lin
Mechanistic heterogeneity in refractory AML
Author(s): S Horibata, J Lack, CB DeStefano, MM Gottesman, CS Hourigan
PTEN status alters the molecular route to resistance to BRAF inhibitor in melanoma
Author(s): L Huang, Y Qin, Q Zuo, T Hawley, C Seo, H Zhang, G Merlino, Y Yu
Olanzapine administration reduces chemotherapy-induced body weight loss and pica in rats
Author(s): RB Jaime-Lara, T Borner, R Holland, E Shaulson, B Brooks, BC De Jonghe
Diagnostic and prognostic utility of urinary creatine riboside for early stage non-small cell lung cancer
Author(s): Y Kanke, T Oike, A Parker, M Haznadar, GT Pauly, KW Krausz, AI Robles, ED Bowman, FJ Gonzalez, CC Harris
The significance of genomic instability and tumor-associated gene mutations for the prognosis of breast cancer in postmenopausal patients
Author(s): A-S Liegmann, A Lischka, JK Habermann, T Ried, K Heselmeyer-Haddad
Natural killer cell-induced cytotoxicity in fatigued cancer patients
Author(s): JK Liwang, LR Feng, LN Saligan
From NIH-Bench to Bedside: An open-label, non-randomized Phase I clinical trial of HER2 (NCT01730118) dendritic cell cancer vaccine
Author(s): HM Maeng, LV Wood, LC England, LB Wisch, S Webb, BD Roberson, BN Moore, DF Stroncek, JC Morris, JA Berzofsky
Cytoplasmic CBFB regulates the translation of nuclear RUNX1 to suppress breast cancer; implications in tumor initiation and progression
Author(s): H Yan, N Moshkovich, M Palangat, H Yang, V Sanchez, Z Cai, T Peat, S Jiang, C Liu, M Lee, BA Mock, SH Yuspa, D Larson, LM Wakefield, J Huang
Preclinical Evaluation of Therapeutic Compounds in Mouse Models for Cancer at the Center for Advanced Preclinical Research (CAPR)
Author(s): L Szabova, R El Meskini, T Vilmas, B Karim, S Jones, S Sharan, S Kozlov, Z Weaver Ohler
Characterization of mitochondrial metabolic oscillations in live rodents
Author(s): Y Ng, D Chen, N Porat-Shliom, Y Chen, W Losert, R Weigert
Novel tumor suppressive role of Peptidylarginine IV involving cancer stem cell regulation in a breast cancer model
Author(s): HJ Ochoa, N Moshkovich, B Tang, LM Wakefield
Pre-clinical identification of therapeutic targets in Type 1 Papillary Renal Cell Carcinoma
Author(s): R Pahwa, A Giri, J Dubhashi, C Sourbier, T Craig, WM Linehan, L Neckers, R Srinivasan
Metformin and JQ1 Synergistically Inhibit Obesity-Activated Thyroid Cancer
Author(s): S Park, M Willingham, J Qi, SY Cheng
Cross-talk of lysine acetylome and tyrosine phosphoproteome unveils abnormal cell signaling of acquired resistance to EGFR inhibitors in lung adenocarcinoma
Author(s): Y Qi, T Maity, X Zhang, U Guha
Integration of Biotherapeutics in Combination Screening with Small Molecule Libraries
Author(s): JS Roth, L Chen, J Travers, CA Klumpp-Thomas, Z Itkin, C McKnight, P Shinn, R Guha, Y Fu, M Ho, ME Yohe, DJ Urban, MD Hall
Precision targeting of M2-like macrophages by the innate defense regulator RP-182 in malignant and non-cancerous diseases
Author(s): JM Jaynes, WB Guzman, M Ronzetti, Z Knotts, T Aiken, M Dashnyam, A Singh, R Calvo, D Li, T Guerin, J White, R Amin, R Hughley, L Fan, M Ferrer, J Morgan, C Yates, B Bolormaa, U Rudloff
Combined Genetic Knockdown and High-Content Image Analysis-based Approach to Discovering Novel Inhibitors of Mutant p53-Stabilizing Factors in Ovarian Tumors
Author(s): DJ Schilling, SD Mazur, E Appella, TS Karpova
Novel Targeting of Transcription and Metabolism in Glioblastoma
Author(s): Y Su, R Chen, H Wang, H Song, Q Zhang, L Chen, T Estok, G Vasconcelos, A Lita, D Maric, A Li, O Celiku, W Zhang, K Meetze, C Yang, M Larion, M Abu-Asab, Z Zhuang, MR Gilbert, J Wu
Characterization of the protein kinase TNIK as a new therapeutic target for lung squamous cell carcinoma
Author(s): P Torres-Ayuso, E An, R Liang, K Nyswaner, J Brognard
Activation of the Wnt/β-Catenin signaling pathway in glioma stem cells impacts blood-brain barrier integrity
Author(s): A Vezina, MR Gilbert, S Jackson
Clusterin regulates a highly aggressive subgroup of pancreatic cancer
Author(s): L Wang, S Yang, W Tang, P He, SP Hussain
Factor it in: A new approach to modeling the pediatric cancer, Wilms tumor, in culture
Author(s): HM Wojcik, AO Perantoni
Comprehensive Molecular Characterization of Mitochondrial Genomes in Spontaneous and Chemical-induced Hepatocellular Carcinomas in B6C3F1/N mice
Author(s): M Xu, A Burkholder, D Fargo, J Marzec, S Kleeberger, G Solomon, R Sills, A Pandiri
Pathways affected by Tamoxifen treatment inferred by human and rat expression data
Author(s): HH YANG, HT LIU, R LUBET, MP LEE
Mice with a “deletor” phenotype allow identification of tumor suppressor genes and oncogenic fusion genes in lymphoid malignancies
Author(s): MM Yin, TB Baslan, A Freeland, SC Pruitt, PD Aplan
Mice with a “deletor” phenotype allow identification of tumor suppressor genes and oncogenic fusion genes in lymphoid malignancies
Author(s): MM Yin, T Baslan, A Freeland, SC Pruitt, PD Aplan
Modulation of anion channel gating by C-terminal domains in excitatory amino acid transporters
Author(s): SG Amara, D Torres-Salazar
Bioreactor mimicry of blood vessel oxygen delivery alters cancer cell growth and gene expression patterns
Author(s): MM Gottesman, WJ Wulftange, M Garmendia-Cedillos, NY Morgan, TJ Pohida, RW Robey
Development of an Exosome / EV Analysis Pipeline for Tumor and Immune Monitoring
Author(s): JC Jones, JA Welsh, J Kepley, TA Waldmann, K Conlon, G Franchini, JL Gulley, KA Camphausen, JA Berzofsky
miR-204 Induced Alterations in RPE/Retinal Structure and Function Mediated by Autophagic and Endo-lysosomal Activity: Implications for Homeostasis and Disease
Author(s): C Zhang, KJ Miyagishima, L Dong, R Sharma, A Rising, R Dejene, M Nimmagadda, Y Wang, A Maminishkis, S Miller
Age-dependent role of Armc5 in mouse adrenal: from hypo- to hyper function
Author(s): A Berthon, FR Faucz, S Espiard, L Drougat, J Bertherat, CA Stratakis
CYCLOXYGENASE (COX-2) NEGATIVELY REGULATES LUNG INNATE LYMPHOID TYPE 2 (ILC2) CELL DIFFERENTIATION DURING ALLERGIC LUNG INFLAMMATION
Author(s): H Li, JA Bradbury, ML Edin, JP Graves, A Gruzdev, LM DeGraff, DC Zeldin
MiCId GUI: A Toolbox for Microorganism Classification, Identification, and Metaproteomics Analysis
Author(s): G Alves, AY Ogurstsov, YK Yu
Development of a literature web search tool and knowledgebase for microbiome functional analysis and annotation
Author(s): Y Zhang, A Biragyn, J Engel, KG Becker
Epitope Mapping of Plasmodium falciparum Pfs47 Reveals a Novel Malaria Transmission-Blocking Target
Author(s): GE Canepa, A Molina-Cruz, L Yenkoidiok-Douti, AE Williams, E Calvo, C Barillas-Mury
Use of prophylactic NSAIDs to improve tolerability of malaria-associated symptoms at high doses of Sanaria® PfSPZ-CVac (PfSPZ Challenge under chloroquine prophylaxis)
Author(s): DM Cook, A Mwakingwe-Omari, SA Healy, J Lane, S Pfeiffer, S Kalhori, C Wyatt, I Zaidi, T Murshedkar, A Ruben, S Chakravarty, A Manoj, A Gunasekera, B Kim Lee Sim, PF Billingsley, ER James, TL Richie, SL Hoffman, PE Duffy
Development and validation of a field deployable quantitative real-time polymerase chain reaction assay (qRT-PCR) for Ebolavirus
Author(s): DM Figueroa, E Kuisma, MJ Matson, T Bushmaker, SN Seifert, S Olson, RJ Fischer, VJ Munster
Clonal evolution and genomic diversification of Bordetella hinzii in an immunocompromised host
Author(s): A Launay, PP Khil, PT Mc Gann, E Snesrud, JH Youn, SM Holland, JP Dekker
Peptide-Specific Engagement of Cerebrovascular Endothelial Cells Promotes Dysfunctional Calcium Signaling During Experimental Cerebral Malaria
Author(s): M Manglani, AB Silva, T Lodhi, DB McGavern
Optimization of sand fly embryo microinjection for gene editing by CRISPR/Cas9
Author(s): I Martin-Martin, A Aryan, C Meneses, ZN Adelman, JMC Ribeiro, E Calvo
Pseudovirus rVSVdeltaG-ZEBOV-GP infects murine neurons in the retina and CNS causing apoptosis and neurodegeneration
Author(s): IL MacWilliams, JL Kielczewski, D Ireland, J Sykes, A Lewkowicz, B Xu, CC Chan, R Caspi, M Manangeeswaran, D Verthelyi
FliA-Dependent Small RNAs Integrate Metabolism and Flagella Biosynthesis
Author(s): S Melamed, J Mills, A Zhang, M Jarnik, G Storz
Computational Image Analysis and Deep Learning for Malaria Parasite Detection and Quantification
Author(s): M Poostchi, S Jaeger, G Thoma
Metals increase the pathogenicity of the skin microbiome
Author(s): A Stacy, Y Belkaid
The TB Portals Program, a multi-national collaboration to advance TB research through data sharing and analysis
Author(s): A Rosenthal, A Gabrielian, K Wollenberg, E Engle, M Harris, J Taaffe, D Hurt, M Tartakovsky
Identifying Genes to Predict Cancer Radiotherapy-Related Fatigue with Machine-Learning Methods
Author(s): S Tu, K Dickinson, CA Johnson, LN Saligan
Characterization of Plasmodium berghei PbP47 as a Malaria Transmission Blocking Vaccine Target
Author(s): L Yenkoidiok Douti, GE Canepa, C Barillas-Mury
Poster Session III
Thursday, September 13, 2018 — 12:00 p.m. – 1:30 p.m. — FAES Terrace
Targeting the EWS-FLI1 pre-mRNA in Ewing Sarcoma through small molecule microarray screening
Author(s): RE Boer, C Neckles, S Kim, DR Calabrese, JS Schneekloth, N Caplen
Chemical and Structural Studies Provide a Mechanistic Basis for Selective Recognition of the MYC G-Quadruplex
Author(s): DR Calabrese, X Chen, E Leon, S Gaikwad, Z Phyo, WM Hewitt, S Alden, TA Hilimire, F He, A Michalowski, JK Simmons, LB Saunders, S Zhang, D Conners, KJ Walters, BA Mock, JS Schneekloth
Bright, stable, heptamethine cyanine fluorophores for in vivo imaging
Author(s): MP Luciano, RR Nani, GM Kline, MJ Schnermann
Inhibition of pre-miRNA-21 processing by bPGN leads to cell cycle arrest in colorectal cancer cells
Author(s): JS Matarlo, LRH Krumpe, SS Kurian, WF Heinz, SJ Lockett, BR O'Keefe
Emotional reactivity in anxiety disorder subtypes: an examination of Social and Generalized Anxiety Disorder
Author(s): B Foote, L Cui, Y Xiao, K Witonsky, A Riddle, K Merikangas
Accounting for random observation time in risk prediction with longitudinal markers: an imputation approach
Author(s): Y Han, D Liu
Analysis of public data dictionaries and study reports from human clinical trials: A case study in HIV/AIDS research
Author(s): V Huser, KW Fung
Is taking folate associated with lower risk of diabetes in pregnancy? A prospective cohort study among 14,622 women
Author(s): M Li, S Li, JE Chavarro, AJ Gaskins, SH Ley, SN Hinkle, X Wang, M Ding, G Bell, AA Bjerregaard, S Olsen, JL Mills, FB Hu, C Zhang
Influence of maternal genetic risk scores of lipid traits on offspring birthweight in diverse ethnic populations
Author(s): M Ouidir, P Mendola, J Grewal, KL Grantz, C Zhang, J Wu, F Tekola-Ayele
Joint mixed-effects models to address unmeasured confounding and selective attrition in vitamin D epidemiology research
Author(s): MD Shardell, L Ferrucci
Prospective cohort study of the oral microbiota and colorectal cancer risk
Author(s): E Vogtmann, X Hua, MH Gail, Y Wan, JG Caporaso, B Hicks, K Jones, A Hutchinson, C Dagnall, J Shi, L Beane Freeman, ND Freedman, CC Abnet, R Sinha
Time-of-day patterns and symptomology of migraine attacks assessed in real-time via mobile technologies
Author(s): KR Witonsky, L Cui, T Lateef, Y Xiao, KR Merikangas
A General Framework for Modeling Diurnal and Weekly Trends in Ecological Momentary Assessment Data
Author(s): Y Xiao, KR Merikangas, V Zipunnikov
Classical monocyte frequency associated with non-calcified coronary plaque burden by CCTA in psoriasis
Author(s): M Aksentijevich, HL Teague, AK Dey, YA Elnabawi, J Groenendyk, E Stansky, J Silverman, M Svirydava, AS Reddy, S Rose, P Dagur, J Philip McCoy Jr, MP Playford, V Sandfort, MY Chen, JM Gelfand, DA Bluemke, NN Mehta
ICAM1low defines a population of tumor-associated neutrophils that promote optimal response to chemotherapy and are regulated by the microbiota
Author(s): RE Araya, KC Lam, A Huang, Q Chen, A Gaines, N Mihelson, M Di Modica, L Magalhaes, RS Goldszmid
Analysis of T-cell populations in dogs with canine leukocyte adhesion deficiency treated by gene therapy
Author(s): TR Bauer Jr, JJ Rose, LM Tuschong, DD Hickstein
Construction of a phage-displayed naïve nurse shark VNAR single domain antibody library and its large diversity revealed by next-generation sequencing analysis
Author(s): H Bian, M Feng, X Wu, T Fu, J Hong, B Felming, M Flajnik, M Ho
Ocular autoimmunity develops in the concurrent absence of IFN-γ and IL-17 and is driven by GM-CSF
Author(s): SJ Bing, PB Silver, Y Jittayasothorn, R Horai, RR Caspi
Immune cell modulation of pulsed focused ultrasound in murine melanoma and breast cancer models
Author(s): P Chandran, G Cohen, R Lorsung, O Aydin, SR Burks, JA Frank
Understanding the Clinical Complexity of Sjögren’s Syndrome through High Definition Autoantibody Profiling
Author(s): A Chaturvedi, BM Warner, PD Burbelo
Heterodimeric IL-15 disrupts follicular viral sanctuaries in lymph nodes and reduces SHIV RNA in macaques
Author(s): S Devasundaram, A Valentin, DC Watson, E Moysi, C Bergamaschi, SP Fortis, C Deleage, JD Estes, E Chertova, JD Lifson, C Petrovas, BK Felber, GN Pavlakis
Allogeneic bone marrow transplantation for STAT3 deficiency
Author(s): D Dimitrova, AF Freeman, SM Holland, JA Kanakry
PAK1 kinase promotes activated T cell trafficking by regulating the expression of CD62L and CCR7
Author(s): AD Dios-Esponera, N Melis, B Subramanian, CA Parent, R Weigert, LE Samelson
Multi-phenotype CRISPR-Cas9 screens identify p38 kinase as a target for adoptive immunotherapies
Author(s): D Gurusamy, S Vodnala, R Kishton, A Eidizadeh, L Jia, CM Kariya, TN Yamamoto, DC Palmer, Z Yu, JH Pan, R Eil, M Sukumar, SJ Patel*, NP Restifo*
Biomarker detection using MALDI imaging
Author(s): J Hicks, M Davisson, H Kalish, G Fabozzi, C Petrovas
T cell mediated immunosuppression contributes to the progression of NF1 associated tumors in the PNF & NPcis mouse model
Author(s): S Karmakar, RG Tuskan, K Pendo, I Shetty, BC Widemann, KM Reilly
Oral R848 Reduces Host Susceptibility to Enteric and Systemic L. monocytogenes Challenge
Author(s): N Kayraklioglu, BH Horuluoglu, M Elango, DM Klinman
Dendritic cell activation and functions after mucosal immunization of rhesus macaques with replicating adenovirus-SIV recombinants
Author(s): E Ko, S Helmold Hait, MA Rahman, G Enyindah-Asonye, T Hoang, M Robert-Guroff
Enhanced Bone Marrow Homing Of Natural Killer Cells By mRNA Transfection With Gain-Of-Function CXCR4
Author(s): ER Levy, RN Reger, MC Carlsten*, RW Childs*
Chronic inflammation driven by IFN-g leads to global disruption of monocyte/macrophage homeostasis
Author(s): L Magalhaes, Q Chen, A Huang, K Lam, R Araya, G Altan-Bonnet, R Goldszmid
Single-cell resolution profiling of tumor-reactive CD4 T-cells reveals immune landscape alterations
Author(s): A Magen, J Nie, T Ciucci, Y Zhao, M Mehta, B Tran, S Hannenhalli, R Bosselut
Sequential innate and adaptive immunity establishes non-inflammatory gut commensalism and physiologic host lipid metabolism
Author(s): K Mao, AP Baptista, S Tamoutounour, L Zhuang, N Bouladoux, AJ Martins, Y Huang, MY Gerner, Y Belkaid, RN Germain
Abdominal therapeutic ultrasound attenuates DSS-induced acute colitis through the cholinergic anti-inflammatory pathway
Author(s): NS Nunes, P Chandran, M Sundby, F Visioli, FC Goncalves, SR Burks, AH Paz, JA Frank
A genome-wide screen identifies a critical role for mitochondrial NDP Kinases in inflammasome activation
Author(s): O Rabinovich Ernst, J Sun, B Lin, B Banoth, C Rice, S Katz, SJ Vayttaden, M Dorrington, J Liang, N Slepushkina, E Buehler, Z Wang, D McVicar, J Khillan, C Bryant, F Sutterwala, S Martin, M Lal-Nag, I Fraser
Aortic distensibility is inversely related to fat distribution in patients with psoriasis
Author(s): AS Reddy, JW Groenendyk, A Goyal, P Shukla, AK Dey, YA Elnabawi, JP Rivers, M Aksentijevich, JA Rodante, H Choi, HA Teague, MA Ahlman, MP Playford, JM Gelfand, J Yao, NN Mehta
The Effects of Altered TGFβ Signaling on Human T Follicular Helper Cell Development and Function
Author(s): Z Schmiechen, K Weissler, K Laky, P Guerrerio
IL-5 driven tissue eosinophils may limit muscle damage in Duchenne muscular dystrophy (mdx) mice
Author(s): AC Sek, IA Moore, K Pak, JG Tidball, HF Rosenberg
Macrophage-fibroblast mutual crosstalk in skin adventitia maintains hypodermal integrity
Author(s): B Voisin, T Doebel, Y Hu, M Kelly, T Kobayashi, D Kim, S Sohn, S Abboud-Werner, M Kelley, C Yan, K Nagao
Peanut-specific CD4+ effector and regulatory T cells in peanut allergic and non-allergic individuals
Author(s): KA Weissler, M Rasooly, T DiMaggio, H Bolan, D Cantave, D Martino, MR Neeland, MLK Tang, TD Dang, KJ Allen, PA Guerrerio
Peanut-specific CD4+ effector and regulatory T cells in peanut allergic and non-allergic individuals
Author(s): KA Weissler, M Rasooly, T DiMaggio, H Bolan, D Cantave, D Martino, MR Neeland, MLK Tang, TD Dang, KJ Allen, PA Guerrerio
Novel protease inhibitors markedly adapting to the structural plasticity of HIV-1 protease exert extreme potency with high genetic barrier
Author(s): H Bulut, M Aoki, H Hayashi, H Aoki-Ogata, S Hattori, AK Ghosh, H Mitsuya
Observed Structural Heterogeneity of Human Hepatitis B Virus Surface Antigen Particles by Cryo-electron Microscopy
Author(s): JR Gallagher, AK Harris
Structural basis of tRNA aminoacylation-dependent transcription attenuation by a T-box riboswitch
Author(s): S Li, ZM Su, J Lehmann, V Stamatopoulou, N Giarimoglou, FE Henderson, LX Fan, YX Wang, C Stathopoulos, W Chiu, JW Zhang
Disorder, disulfides and domain-swaps in an oxidized octamer of a gamma S crystallin
Author(s): V Sagar, G Wistow
Estimating plasma glucose with FreeStyle Libre Pro CGM during OGTT in youth
Author(s): N Ghane, MM Broadney, SM Collins, EK Davis, SM Brady, JA Yanovski
Multiplex dynamic reporters enable single cell temporal analysis of costimulatory and cytokine receptor engagement effects on TCR signaling
Author(s): W Chan, M Cao, M Smelkinson, J Kabat, C Bradfield, JL Hor, RN Germain
Morphometric analysis of astrocytes in brainstem respiratory regions
Author(s): S Sheikhbahaei, B Morris, J Collina, S Anjum, S Znati, JL Gamarra, R Zhang, AV Gourine, JC Smith
Mass Spectrometry Analysis of Protein Interactors for Pre-let-7 miRNA
Author(s): GC Lyons, P Legault, MK Meffert, LM Jenkins
Targeted Proteomics-Driven Computational Modeling of Macrophage Microbial Sensing Pathways
Author(s): NP Manes, JM Calzola, PR Kaplan, M Meier-Schellersheim, IDC Fraser, RN Germain, A Nita-Lazar
Cell-type-specific interpretation of pathogen information via single-cell NF-kappaB dynamics
Author(s): EW Martin, A Pacholewska, H Patel, H Dashora, MH Sung
Integrative analysis of molecular expression from blood of chronic abdominal pain and weight phenotypes provides differential clinical profiles for translational research
Author(s): JM Robinson, C Boulineaux, S Turkington, NH Fourie, WA Henderson
Systems Immunology of Malaria: an ImmPort shared data set for data mining and meta-analysis
Author(s): J Skinner, TM Tran, R Guja, S Portugal, A Ongoiba, M Jones, P Venepally, J Moebius, S Doumbo, S Li, E Deriso, G Alter, E O'Connell, E Thomson, PJ Dunn, OK Doumbo, K Kayentao, B Traore, EF Kirkness, PD Crompton
Towards a general indicator of immune responsiveness: A baseline blood transcriptomic signature that correlates with vaccination response and lupus disease activity
Author(s): R Sparks, Y Kotliarov, Y Lu, M Goswami, L Kardava, AJ Martins, CC Liu, S Moir, JS Tsang
Antibody Enhanced Entry of Kaposi’s Sarcoma Associated Herpesvirus/ Human Herpesvirus 8 into B-cells via the FC Gamma II Receptor/CD32
Author(s): SJ Dollery, EA Berger
Testing antivirals in the cell-based ELISA: factors that influence the potency of drugs
Author(s): RA Gross, E Postnikova, Y Cong, LE Dewald, BJ Hart, J Dyall, H Zhou, N Deiuliis, J Michelotti, A Honko, RS Bennett, MR Holbrook, GG Olinger, LE Hensley, PB Jahrling
Electron microscopy characterization of commercially available influenza vaccines
Author(s): NM Gulati, ML Myers, AK Harris
Structural Characterization of HIV Env Glycoprotein by LC-MS
Author(s): VB Ivleva, FJ Arnold, JW Cooper, QP Lei
MRI and CT can detect multiorgan failure due to Ebola virus in rhesus macaque model
Author(s): JH Lee, D Thomasson, M Castro, J Solomon, J Laux, C Bartos, K Hagen, PB Jahrling, IM Feuerstein, RF Johnson
Examining the effect of producer cell-type on the target cell tropism of KSHV
Author(s): TD Maldonado, EA Brenner, SJ Dollery, EA Berger
Influenza vaccine nanoparticle design and evaluation assisted by cryo-electron microscopy
Author(s): DM McCraw, ML Myers, MT Conlon, NM Gulati, JR Gallagher, U Torian, AK Harris
mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3
Author(s): GL Shi, S Ozog, K Hermann, BE Torbett, AA Compton
Poster Session IV
Thursday, September 13, 2018 — 3:30 p.m. – 5:00 p.m. — FAES Terrace
Low Intensity Ultrasound Prolongs Lifetimes of Mesenchymal Stem Cell Transplants Through Interferon-γ and Hypoxia Inducible Factor 1-α Signaling
Author(s): SR Burks, RM Lorsung, JA Frank
Atomic Force Microscopy: High Resolution Imaging and Force Spectroscopy in Biology
Author(s): EK Dimitriadis
A method for the automated generation of patient-specific prostate molds for guided fresh tissue procurement and validating MRI lesion localization
Author(s): MA Garmendia, RZ Freidlin, CG Bastian, JA Krynitsky, TJ Pohida, S Mehralivand, MJ Merino, PA Pinto, PL Choyke, IB Turkbey
Optimal parameter selection of PRiME adaptive noise cancellation for reduction of MRI interference on electrocardiography signals
Author(s): JW Kakareka, T Arginteanu, DA Herzka, RH Pursley, DR McGuirt, RJ Lederman, TJ Pohida
MIOS Cage Cam – A Cloud-based Homecage-Integrated Waste Monitoring Device to Improve Animal Care
Author(s): JA Krynitsky, ME Gardiner, MA Garmendia, MA Ali, GH Salem, JU Dennis, AV Kravitz, TJ Pohida
Human reconstructed epidermis and vascularized bioprinted skin tissues as tissue-in-a-dish models for drug screening
Author(s): X Liu, MJ Song, S Michael, M Ferrer
Intracellular Ca2+ signaling from pulsed focused ultrasound is initiated by mechanical activation of TRPC1 Na+ currents
Author(s): RM Lorsung, JA Frank, SR Burks
Microfabricated structures for biology
Author(s): NY Morgan, S Kantesaria, W Wulftange
Characterization of VDAC3 isoform channel activity and its putative role in mitochondria homeostasis and neurodegeneration
Author(s): M Queralt-Martin, L Bergdoll, J Abramson, TK Rostovtseva, SM Bezrukov
Visualizing and explaining deep learning predictions for pneumonia detection in pediatric chest radiographs
Author(s): S Rajaraman, S Candemir, GR Thoma, SK Antani
Effect of steroids on mitochondrial metabolite channel function and lipid membrane properties
Author(s): WM Rosencrans, M Queralt-Martín, A Rovini, P Gurnev, S Bezrukov, T Rostovtseva
Measuring Macromolecular Size-Distributions and Interactions at High Concentrations
Author(s): SK Chaturvedi, J Ma, PH Brown, H Zhao, P Schuck
Rapid, Point-of-Care Test for GI Pathogens in Stool
Author(s): L Xiang, AF Diallo, NH Fourie, SK Abey, EG Fergusin, N Kenea, C Kim, W Henderson
Rapid, Point-of-Care Test for GI Pathogens in Stool
Author(s): L Xiang, AF Diallo, NH Fourie, SK Abey, EG Fergusin, N Kenea, C Kim, W Henderson
Truncated tetrahedral RNA nanostructures act as improved scaffolds for delivery of RNAi-based therapeutics
Author(s): P Zakrevsky, WK Kasprzak, WF Heinz, N Dorjsuren, EA Fields, L Jaeger, BA Shapiro
Cooperativity in the Interactions of HIV-1 Gag Protein with Short Nucleic Acid
Author(s): H ZHAO, S DATTA, S KIM, S CHATURVEDI, A REIN, P SCHUCK
Phase Separation of YAP in Osmotic Stress Transiently Shuts Down Transcription and Primes YAP for Long-term Target Gene Expression
Author(s): D Cai, S Sukenik, D Feliciano, M Gruebele, J Lippincott-Schwartz
The importance of iPS-derived astrocytes in in the pathophysiology of GBA1-associated Parkinson disease
Author(s): A Eghbali, B Stubblefield, E Sidransky, E Aflaki
A no-wash, high-throughput, cell-based fluorescence assay using Mirrorball technology to discover small molecule therapeutics for Niemann-Pick disease type A
Author(s): K Gorshkov, M Pradhan, M Xu, S Yang, M Shen, W Zheng
FKBP8 promotes trafficking of adenylate cyclase to primary cilia and regulates ciliary signaling
Author(s): P Hwang, T Li
Peripheral Melanocortin 3 receptor (MC3R) regulates hepatic autophagy in obesity
Author(s): JY Jun, AY Seo, TP Patel, N Levi, AJ Uhlman, RB Roberson, J Lippincott-Schwartz, JA Yanovski
Aortic Tropoelastin Degradation by MFG-E8 Directed p38 mediated signaling
Author(s): SH Kim, RE Monticone, Z Zhang, M Wang, EG Lakatta
Human DnaJB6 anti-amyloid chaperone protects yeast from polyglutamine toxicity separately from spatial segregation of aggregates
Author(s): J Kumar, NL Kline, DC Masison
Lipid Transfer Protein, STARD3 is a Novel Binding Partner of Methionine Sulfoxide Reductase A
Author(s): JM Lim, GS Kim, RL Levine
Hsp90 involved in mitochondrial quality control through mitophagy and fusion/fission pathways
Author(s): CP LIN, DC MASISON
Aryl Hydrocarbon Receptor (AHR) modulates glycosphingolipid production by transcriptional regulation of key genes involved in the de novo biosynthetic pathway
Author(s): S Majumder, M Kono, YT Lee, C Byrnes, RL Proia
A close-up view of mitophagy using mt-keima and super-resolution microscopy
Author(s): D Malide, N Sun, T Finkel
SIP-2/FIP modulates PRC-1/FEO to ensure proper cytokinesis and ploidy
Author(s): RK Ng, ZT Swider, R Varadarajan, NM Rusan
Quantifying actin dynamics in developing Drosophila neurons using LoG filters
Author(s): KM O'Neill, LJ Campanello, J Corbett-Frank, AY Clarke, HY Fang, W Losert, E Giniger
Development of a neuronal model of Niemann-Pick type C1 disease using human induced pluripotent stem cells
Author(s): AV Prabhu, ME Ward, FD Porter
Mixing of parental genomes after fertilization in C. elegans involves a stepwise pronuclear membrane fusion process that connects the two pronuclei through multiple fenestrations
Author(s): MM Rahman, A Harned, I Chang, K Narayan, O Cohen-Fix
Elucidating the Structure of the Glycocalyx-Microvilli Complex on the Surface of a Model Epithelia Cell Using Freeze-Etch and Electron Tomography
Author(s): WS Sun, ES Krystofiak, R Cui, B Kachar
Cell cycle dependent regulation of centrosome maturation by Drosophila Pericentrin
Author(s): R Varadarajan, K Plevock, CJ Fagerstrom, NM Rusan
High-throughput screen for ER/SR calcium stabilizers identifies a drug for partially correcting disease phenotype in RYR1 mutant zebrafish
Author(s): ES Wires, T Lawal, JJ Todd, MJ Henderson, BK Harvey, K Meilleur
A Metabolic Basis for Endothelial-to-Mesenchymal Transition
Author(s): J Xiong, H Kawagishi, Y Yan, J Liu, QS Wells, LR Edmunds, MM Fergusson, ZX Yu, II Rovira, EL Brittain, MJ Wolfgang, JP Fessel, T Finkel
Identify bypass suppressors of mrp-5 deficiency in Caenorhabditis elegans
Author(s): X Yuan, S Beardsley, M Krause, H Smith, I Hamsa
Cell cycle dependent association of polo like kinase Cdc5 with CENP-A regulates faithful chromosome segregation in budding yeast
Author(s): PK Mishra, G Olafsson, L Boeckmann, TJ Westlake, Z Jowhar, LE Dittman, D D'Amours, PH Thorpe, MA Basrai
Transcriptional reprogramming regulated by DNMT3B - histone modification interaction in breast cancer metastasis
Author(s): X Wang, JY So, JD Fan, KJ Zhao, L Yang
Neighborhood Perceptions and Depression: Data from the Washington, D.C. Cardiovascular Health and Needs Assessment
Author(s): MR Andrews, JN Ceasar, K Tamura, VM Mitchell, SD Langerman, TM Powell-Wiley
Community engagement for user-centered design of a physical activity promoting mobile health (mHealth) application
Author(s): JN Ceasar, MR Andrews, SE Claudel, K Tamura, VM Mitchell, A Brooks, T Dodge, S El-Toukhy, N Farmer, K Middleton, M Sabado-Liwag, M Troncoso, G Wallen, TM Powell-Wiley
Flavored Cigar Smoking Among African American Young Adult Dual Users: An Ecological Momentary Assessment
Author(s): JC Chen, K Choi, TR Kirchner, R Feldman, J Butler, EL Mead
Would electronic cigarette (e-cigarette) use reduce health disparities? Prevalence of daily e-cigarette use among cigarette smokers by race/ethnicity, education, and income
Author(s): K Choi, JC Chen
Non-Nutritive Sweetener Exposure Begins Early in Life
Author(s): EM Conway, ET Beulick, EL Ball, AC Sylvetsky, AB Courville, PJ Walter, H Cai, MA Hoskin, MA Clark, RL Hanson, WC Knowler, KI Rother
“Isn’t there a bunch of side effects?”: A Focus Group Study on Young Adult Smokers’ Beliefs About Cessation Treatments
Author(s): DA Duarte, J Chen, K Dang, B Jewett, L Orozco, K Choi
Using Inflammatory Correlates to Predict Type 2 Diabetes Mellitus in US Adults
Author(s): A Amare, SH Jackson
Young Adult Smokers’ Reactions to Smoking Cessation Campaigns: A Qualitative Study
Author(s): L Orozco, B Jewett, J Chen, D Duarte, K Dang, K Choi
IFNL4-ΔG predisposes to aggressive prostate cancer among men at increased risk of sexually transmitted infections
Author(s): TZ MINAS, W TANG, CJ SMITH, TH DORSEY, SV JORDAN, OM OBADI, L PROKUNINA-OLSSON, BM RYAN, CA LOFFREDO, S AMBS
Step It Up: targeted user experience testing and community engagement in development of a mobile health technology-enabled physical activity app
Author(s): SH Xu, JN Ceasar, SE Claudel, MR Andrews, K Tamura, VM Mitchell, S Mye, R McCoy, J Zahurak, L Balian, S Guiliano, TM Powell-Wiley
β3 adrenergic receptors are key to lipolysis and thermogenesis in humans
Author(s): C Cero, A O'Mara, J Johnson, J Linderman, A Cypess
Novel mechanisms for increased gut leakiness, systemic endotoxemia and inflammatory liver injury by binge alcohol or fructose exposure
Author(s): YE Cho, BJ Song
Understanding the Role of CYP3A7 in Drug Metabolism to Advance Drug Discovery in Pediatric Populations
Author(s): MS Kabir, S Sakamuru, E Gonzalez, R Huang, EC Padilha, J Braisted, AQ Wang, M Xia, X Xu, P Shah
Colchicine to Treat Metabolic Syndrome: Results from a Pilot Randomized Controlled Trial
Author(s): J Levine, AP Demidowich, G Onyekaba, S Khan, MM Broadney, S Brady, JA Yanovski
Identification of Positive Allosteric Modulators of the D1 Dopamine Receptor that act at diverse binding sites
Author(s): KD Luderman, JL Conroy, RB Free, N Southall, M Ferrer, M Sanchez-Soto, AE Moritz, BKA Willette, TJ Fyfe, P Jain, S Titus, LA Hazelwood, J Aubé, JR Lane, KJ Frankowski, DR Sibley
Development of a quantitative bioanalytical method for the assessment of benserazide pharmacokinetics in pre-clinical studies
Author(s): Amy Wang, K Konrath, G Dunn, E Hughes, M Singleton, S Haugabook, S Perrine-Faller, Xin Xu
A positive allosteric modulator that promotes insulin secretion in mice by selectively enhancing M3 muscarinic receptor signaling in beta-cells
Author(s): Lu Zhu, M Rossi, A Cohen, H Zheng, JL Langel, S Hattar, D Apella, NM Doliba, J Wess
SIRT1 regulates cardiomyocyte alignment and contraction during maturation in part through deacetylation of ACTN2
Author(s): Y Fang, W Fan, X Xu, S Tang, H Huang, AK Janoshazi, Y Zhao, DC Fargo, X Li
Manufacturing GMP Grade Induced Pluripotent Stem Cell (iPSC) to Support Clinical Trials
Author(s): F Hua, S Sarkar, A Thakkar, S Highfill
The use of genetic engineering in human embryonic stem cells to develop a model system to investigate neuropathic pain in Fabry Disease
Author(s): CR Kaneski, JA Hanover, UH Schueler
Conversion of human pluripotent stem cells to sensory neurons by transcriptional programming
Author(s): AR Nickolls, MM Lee, R Lam, M Szczot, D Espinoza, ME Ward, AT Chesler, CG Bonnemann
Periosteal Cells Derived from Long Bone are Unique from those Derived from Calvaria
Author(s): R Shainer, V Kram, TM Kilts, CG Simon Jr, MF Young
Development and validation of GMP grade Retinal Pigmented Epithelial (RPE) cells from autologous induced Pluripotent Stem Cells (iPSC)
Author(s): A Thakkar, S Sarkar, F Hua, S Highfill, K Bharti, BS Jha, D Stroncek
Development and validation of GMP grade Retinal Pigmented Epithelial (RPE) cells from autologous induced Pluripotent Stem Cells (iPSC)
Author(s): A Thakkar, S Sarkar, F Hua, S Highfill, K Bharti, BS Jha, D Stroncek
Poster Session V
Friday, September 14, 2018 — 12:00 p.m. – 1:30 p.m. — FAES Terrace
Magic-BLAST, an accurate DNA and RNA-seq mapper for long and short reads
Author(s): GM Boratyn, J Thierry-Mieg, D Thierry-Mieg, TL Madden
Nucleotide and codon background mutability shape cancer mutational spectrum and advance driver mutation identification
Author(s): AL Brown, M Li, A Goncearenco, AR Panchenko
DiscoverSL: An R package for Multi-omic data driven prediction of synthetic lethality in cancers
Author(s): S Das, X Deng, K Camphausen, U Shankavaram
Computational methods for analysis of somatic background mutational processes in cancer
Author(s): A Goncearenco, AL Brown, M Li, C Cunningham, IB Rogozin, AR Panchenko
A computational framework for predicting obesity risk based on optimizing and integrating genetic risk score and gene expression profiles
Author(s): PV Joseph, Y Wang, NH Fourie, WA Henderson
The use of deep learning feature extraction of CXRs can improve classification of tuberculosis
Author(s): O Juarez-Espinosa, A Gabrielian, E Engle, D Hurt, A Rosenthal
A novel computational deconvolution method to dissect heterogeneity using bulk RNA-seq data
Author(s): K Kang, Q Meng, I Shats, DM Umbach, L Li
Adapting METAGENOTE to greatly facilitate all genomic sequencing data submissions to the NCBI Sequence Read Archive (SRA) prior to publication
Author(s): M Quiñones, D Liou, C Shyu, L Kim, D Hurt
Nephele 2.0: A robust online microbiome analysis platform
Author(s): M Quiñones, L Kim, P MacMenamin, J Dommer, P Subramanian, C Shyu, S Ezeji, N Weber, D Hurt
Implementing Clinical Data Warehouse using CDISC for analysis and management of clinical trials
Author(s): J Singh, H Kandaswamy, JD Otoo, P Gumne, I Kaur, S Debrincat, C Whalen, M Tartakovsky
Implementing Clinical Data Warehouse using CDISC for analysis and management of clinical trials
Author(s): J Singh, H Kandaswamy, JD Otoo, P Gumne, I Kaur, S Debrincat, C Whalen, M Tartakovsky
Activity of APOBEC3A, APOBEC3B, REV1, UNG, and FHIT is Associated with Drug Sensitivity in Specific Cancer Subtypes
Author(s): S Vural, R Simon, J Krushkal
Deep Learning Workflows for Cell Nucleus Segmentation from Fluorescence Microscopy Images
Author(s): G Zaki, P Gudla, J Kim, S Shachar, T Misteli, G Pegoraro
Mobile augmented reality application for biomedical research and education
Author(s): K Zhang, P Cruz, M McCarthy, D Hurt
Acetylation of cytidine in messenger RNA promotes translation efficiency
Author(s): D Arango, DM Sturgill, N Alhusaini, AA Dillman, TJ Sweet, G Hanson, WR Sincalir, M Hosogane, KK Nanan, SD Fox, TT Zengeya, T Andresson, JL Meier, J Coller, S Oberdoerffer
A high-throughput platform to examine G-quadruplex DNA formation and recognition
Author(s): NM Assad, D Tillo, S Ray, JS Schneekloth, C Vinson
A Comparison of Anthrax-based Double Effector Complexes on Tumor Cell Death
Author(s): PA Bhatia, SH Leppla
Enhanced Insulin Sensitivity and Protection Against Diet-induced Obesity in Transgenic Mice Overexpressing NQO1
Author(s): A Di Francesco, Y Zhang, K Bullok, K Kalafut, C Di Germanio, J Martindale, M Gorospe, D Willmes, D Siegel, D Ross, M Bernier, R de Cabo
Proteomics Analysis of Skeletal Muscle in Healthy Humans
Author(s): C Ubaida-Mohein, A Lyashkov, R Tharakan, M Gonzalez-Friere, MD Shardell, R Moaddel, C Chia, L Ferrucci
Elucidating the modification status of tRNAs in response to environmental and metabolic stress
Author(s): CM Fitzsimmons, KS McDonald, PJ Batista
Optimizing glypican-3 targeting immunotoxins for the treatment of liver cancer
Author(s): BD Fleming, D Urban, M Hall, T Longerich, T Greten, I Pastan, M Ho
Glypican 3-Specific Antibody-Drug Conjugate for Hepatocellular Carcinoma Treatment
Author(s): Y Fu, M Ho
IQGAP1 binds the Axl receptor tyrosine kinase and inhibits its signaling
Author(s): L Gorisse, Z Li, AC Hedman, DB Sacks
IQGAP1 binds the Axl receptor tyrosine kinase and inhibits its signaling
Author(s): L Gorisse, Z Li, AC Hedman, DB Sacks
YAP transcription is inhibited by insulin
Author(s): AC Hedman, S Sayedyahossein, DB Sacks
Glucose Response Repression of the Estrogen Sulfotransferase by Nuclear Receptors PXR and RORa via Phosphorylation
Author(s): H Hu, M Negishi
Feedback translational regulation of the creatine transporter SCL6A8 implicated in X-linked intellectual disability
Author(s): IP Ivanov, C Cao, TE Dever
H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development
Author(s): Y Jang, B Aaron, C Wang, Y-K Park, L Zhuang, J-E Lee, E Froimchuk, C Liu, K Ge
Synaptamide biosynthesis monitored by stable isotope labeling and high resolution mass spectrometry
Author(s): KR KEVALA, M LAGARDE, AA SPECTOR, HY KIM
Hsp70 independent role of nucleotide exchange factor Fes1 in degradation of gluconeogenic enzymes and cell wall integrity
Author(s): S Kumar, DC Masison
DNA Looping fine-tunes the extreme stability of the prophage state of Bacteriophage Lambda in a lysogen
Author(s): DEA Lewis, GN Gussin, S Adhya
The function of HNRNPH1 in processing the EWS-FLI1 pre-mRNA in a subset of Ewing sarcoma cells
Author(s): CN Neckles, B Boer, S Kim, J Schneekloth, NJ Caplen
The impact of mis-regulated metabolism on post transcriptional m6A RNA modifications
Author(s): AC Schmiechen, PJ Batista
Metabolic characterization of FLCN deficient renal cancer cells using Stable Isotope-Resolved Metabolomics
Author(s): Y Yang, DR Crooks, GM Cawthon, Higashi, Fan
Metabolic characterization of FLCN deficient renal cancer cells using Stable Isotope-Resolved Metabolomics
Author(s): Y Yang, DR Crooks, GM Cawthon, RM Higashi, TWM Fan, AN Lane, LS Schmidt, WM Linehan
Identification of genes involved in photoreceptor recognition and synapse formation
Author(s): J Angueyra, VP Kunze, K Kindt, W Li
Midlife hearing impairment as a risk factor for late-life temporal lobe volume loss
Author(s): NM Armstrong, Y An, J Doshi, G Erus, L Ferrucci, C Davatzikos, JA Deal, FR Lin, SM Resnick
Visual recall memory contains highly detailed and precise object and spatial information
Author(s): WA Bainbridge, EH Hall, CI Baker
Autophagy Pathway Protein Expression and Cellular Distribution in Oligodendrocyte Progenitor Cells
Author(s): J Belgrad, R De Pace, JS Bonifacino, RD Fields
Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons
Author(s): X-T Cheng, Y-X Xie, B Zhou, N Huang, T Farfel-Becker, Z-H Sheng
Amino acid starvation: Differential response to mGluR5 activation in hippocampal slices from WT and Fmr1 KO mice
Author(s): SK Cooke, J Russin, I Louteav, Z Li, CB Smith
Understanding the link between pharmacological manipulation of the ghrelin system and alcohol hangover symptoms: Results from two human laboratory studies
Author(s): M Farokhnia, MR Lee, LA Farinelli, VA Ramchandani, F Akhlaghi, L Leggio
Electrophysiological and Immunohistochemical Analysis of Inhibitory Input to Neurons in the Medial Olivocochlear Circuit
Author(s): MJ Fischl, L Torres Cadenas, I Dame, CJC Weisz
Multiple courses of BBB opening with pulsed Focused Ultrasound and Microbubbles promotes phosphorylated Tau production
Author(s): ZI Kovacs, TW Tu, M Sundby, BK Lewis, SR Burks, JA Frank
GABA-A Receptors on Dopmaine Neuron Axons in the Striatum
Author(s): PF Kramer, ZM Khaliq
Can improving sleep improve behavior in fragile X syndrome?
Author(s): A Lemons, RM Saré, CB Smith
Compulsive methamphetamine taking under punishment increases the expression of AP1 family of transcription factors in the rat nucleus accumbens
Author(s): MT McCoy, B Ladenheim, L Contu, M Job, B Campbell, CA Blackwood, S Jayanthi, JL Cadet
Cerebrovascular reactivity and midlife cognitive decline, a longitudinal sub-study of the Coronary Artery Risk Development in Young Adults (CARDIA) cohort
Author(s): JE Moonen, RN Bryan, E Guray, I Nasrallah, O Meirelles, PJ Schreiner
Cerebrovascular reactivity and midlife cognitive decline, a longitudinal sub-study of the Coronary Artery Risk Development in Young Adults (CARDIA) cohort
Author(s): JE Moonen, RN Bryan, G Erus, I Nasrallah, O Meirelles, PJ Schreiner, C Davatzikos, LJ Launer
Hibernation – with superpower of neural protection?
Author(s): FM Nadal-Nicolas, T Zhao, J Ball, S Chen, JX Ou, VP Kunze, W Li
Unilateral whisker denervation drives synaptic remodeling across the corpus callosum
Author(s): E Petrus, G Saar, Z Ma, S Dodd
Unilateral whisker denervation drives synaptic remodeling across the corpus callosum
Author(s): E Petrus, G Saar, Z Ma, S Dodd, JTR Isaac, AP Koretsky
Adjusting neurofilament light levels using an MRI-based estimate of total axonal bulk impvroves its prediction of MS progression
Author(s): J Phillips, R Masvekar, P Kosa, K Jackson, A Weideman, B Bielekova
Spatial overlap of language networks from resting state fMRI in patients with epilepsy
Author(s): R Rolinski, X You, J Gonzalez-Castillo, R Reynolds, SK Inati, WH Theodore
Longitudinal PET Imaging of the Serotonergic System in SIV Infected Non-Human Primates
Author(s): S Shah, S Sinharay, D Lee, WC Reid, P Wakim, K Matsuda, A Nath, V Hirsch, M Di Mascio, DA Hammoud
Laminar Specific Cortical Plasticity following Mouse Sensory Deprivation
Author(s): KA Sheth, E Petrus, S Dodd, AP Koretsky
Laminar Specific Cortical Plasticity following Mouse Sensory Deprivation
Author(s): KA Sheth, E Petrus, S Dodd, AP Koretsky
Anti-Saccade: An Investigation of Flexible Control
Author(s): AR Subar, E Leibenluft, DS Pine, EM Cardinale
The role of Rapgef2 in the behavioral effects of Cocaine in the Mouse
Author(s): SC Sweat, KM Loane, GL Drossel, SZ Jiang, CR Gerfen, LE Eiden
Correlation of phenotype with genotype and protein structure in RYR1-related disorders
Author(s): JJ Todd, V Sagar, TA Lawal, C Allen, MS Razaqyar, MS Shelton, IC Chrismer, X Zhang, MM Cosgrove, A Kuo, R Vasavada, MS Jain, M Waite, D Rajapakse, JW Witherspoon, G Wistow, KG Meilleur
Rates of cerebral protein synthesis are elevated in a Shank3 knockout mouse model
Author(s): A Torossian, RM Saré, C Figueroa, CB Smith
Converging mechanisms of ribonucleoprotein granule and lysosomal biology in neurodegenerative diseases
Author(s): Y Liao, M Fernandopulle, L Hao, S Qamar, P Hyslop, J Lippincott-Schwartz, M Ward
Converging mechanisms of ribonucleoprotein granule and lysosomal biology in neurodegenerative diseases
Author(s): Y Liao, M Fernandopulle, L Hao, S Qamar, P Hyslop, J Lippincott-Schwartz, M Ward
The impact of age and vascular risk factors on white matter microstructural organization
Author(s): OA Williams, Y An, L Beason-Held, Y Huo, BA Landman, SM Resnick
Adrenergic Beta Receptors and Family B Neuropeptide GPCRs and their Signaling Linkage to ERK through NCS-Rapgef2
Author(s): AN Wilson, AC Emery, W Xu, SZ Jiang, LE Eiden
Carboxypeptidase E/Neurotrophic factor-α1 is a novel neuroprotective protein functioning independently of its prohormone processing enzymatic activity
Author(s): L Xiao, X Yang, VK SHARMA, D ABEBE, A PELTEKIAN, YP LOH
Mechanistic Contribution of Defective Presynaptic Cargo Transport to the Autism-linked Pathogenesis
Author(s): GJ Xiong, YX Xie, T Sun, XT Cheng, N Huang, MY Lin, SN Li, ZH Sheng
Dorsal striatum medial spiny neurons encode motor skill learning
Author(s): L Zhang, B Liang, G Barbera, Y Li, DT Lin
Neural encoding of reward seeking in the medial prefrontal cortex
Author(s): G Barbera, LF Zhang, B Liang, Y Li, Y Shaham, DT Lin