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Clusterin regulates a highly aggressive subgroup of pancreatic cancer

Wednesday, September 12, 2018 — Poster Session II

3:30 p.m. – 5:00 p.m.
FAES Terrace
NCI
CANCER-37

Authors

  • L Wang
  • S Yang
  • W Tang
  • P He
  • SP Hussain

Abstract

Pancreatic cancer is one of the most lethal malignancies and is ranked as 4th leading cause of death due to cancer in the United States. Alarmingly, a consistent rise in incidence and death in pancreatic cancer is estimated to make it the second leading cause of cancer-related death by 2030. Similar to many other cancer, pancreatic ductal adenocarcinomas (PDAC) are highly heterogeneous and the underlying oncogenic mechanisms are poorly understood. We hypothesized that specific molecular signatures stratify PDAC subtype with distinct prognosis. To test this hypothesis, global gene expression profile from 142 tumor tissue samples was performed and three molecular subtypes (G1, G2 and G3) were identified by non-negative matrix factorization (NMF) analysis with consensus clustering. Class comparison between each subtype generated subtype specific gene signature (G1: 148 genes; G2: 217 genes; G3: 123 genes; FC>2, FDR

Category: Cancer Biology