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NIH Research Festival

September 12 – 14, 2018

Clusterin regulates a highly aggressive subgroup of pancreatic cancer

Wednesday, September 12, 2018 – Poster Session II
3:30 – 5:00 p.m.

FAES Terrace

NCI

CANCER-37

Authors

  • L Wang
  • S Yang
  • W Tang
  • P He
  • SP Hussain

Abstract

Pancreatic cancer is one of the most lethal malignancies and is ranked as 4th leading cause of death due to cancer in the United States. Alarmingly, a consistent rise in incidence and death in pancreatic cancer is estimated to make it the second leading cause of cancer-related death by 2030. Similar to many other cancer, pancreatic ductal adenocarcinomas (PDAC) are highly heterogeneous and the underlying oncogenic mechanisms are poorly understood. We hypothesized that specific molecular signatures stratify PDAC subtype with distinct prognosis. To test this hypothesis, global gene expression profile from 142 tumor tissue samples was performed and three molecular subtypes (G1, G2 and G3) were identified by non-negative matrix factorization (NMF) analysis with consensus clustering. Class comparison between each subtype generated subtype specific gene signature (G1: 148 genes; G2: 217 genes; G3: 123 genes; FC>2, FDR

Scientific Focus Area: Cancer Biology

This page was last updated on Friday, March 26, 2021

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2018 program

Download the 2018 Research Festival Schedule Overview (6 pages)

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Current Research Festival

  • 2025
  • 2024
    • General Schedule of Events
    • 2024 NIH Distinguished Scholars Program
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • National Academy of Science Mini-Symposium
    • Special Wednesday Events
    • Vendor Exhibit Information
    • Green Labs Fair
    • Research Festival Committee
  • 2023
    • General Schedule of Events
    • NIH Early–Career Investigator Lectures
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • Vendor Exhibit Information
    • Research Festival Committee
  • 2021
  • 2019
    • General Schedule of Events
    • Plenary Sessions
    • Poster Session
    • Data Blitz
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committee
  • 2018
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committees
  • 2017
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Future Research Leaders
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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  • 2016
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • Browse by Presenter Name
    • Browse by Presenter IC
    • FARE Award Ceremony
    • Future Research Leaders
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Tours of the National Library of Medicine and Clinical Center
    • Research Festival Committees
  • 2015
    • General Schedule of Events
    • Plenary Sessions
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    • Browse by Presenter Name
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