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Concurrent Symposia Sessions

Wednesday, September 14, 2016 • Thursday, September 15, 2016

Wednesday, September 14, 2016

From insight to therapy: bench-to-bedside homeruns

12:30 p.m. – 2:30 p.m.

Masur Auditorium

Chair: John I. Gallin, M.D. (CC) and Constantine A. Stratakis, M.D., D(Med)Sc (NICHD)

Since 1953, the NIH Clinical Center has been home to many great stories that took an idea from the bench to the bedside with tremendous successes as a result. Many (and likely most) of these clinical research discoveries could not have happened as easily anywhere else. This symposium serves to remind intramural colleagues of the rich portfolio of investigators who have hit home run research successes in the Clinical Center. These zealous research teams covered all bases in the lab, and with our patient partners, crossed the home plate in glory! Come hear the amazing lineup of these superstar hitters and, as we prepare for the session, follow us on Twitter: @NIHClinicalCntr!

  • Prostate cancer imaging and targeted biopsies: opportunities to improve diagnosis and treatment
    Peter Pinto, M.D. (NCI-CCR)
  • Stable isotope breath testing to assess in vivo metabolite flux in methylmalonic acidemia: From mouse models to patients
    Irini Manoli, M.D., Ph.D. (NHGRI) and Charles P. Venditti M.D., Ph.D. (NHGRI)
  • Antioxidant therapy in RYR1-related myopathies
    Katherine Meilleur, Ph.D., PPCNP-BC (NINR)
  • The Melanocortin 3 Receptor and Pediatric Obesity: From Bench to Bedside
    Jack A. Yanovski, M.D., Ph.D. (NICHD)
  • FARE award winner, Quantitative high-throughput screening as a tool to identify novel therapies in Bladder Cancer: Lessons from Flavopiridol
    Reema S. Railkar, Ph.D. (NCI-CCR)

The zen of microbiota

12:30 p.m. – 2:30 p.m.

Lipsett Amphitheater

Chair: Julie A. Segre, Ph.D. (NHGRI)

Scientific studies have transformed our thinking of all microbes as enemies to highlight the fundamental roles that human-associated microbes play in promoting health throughout a lifetime. The bacteria, fungi, viruses, and archaea that reside in and on the human body constitute our microbiota, and their genes are our microbiome. In this session, we discuss studies exploring human-associated microbial communities to understand the etiology the disease and design interventions to promote health and treat disease.

  • Genomic sequencing and analysis advances in Skin Microbiome Studies
    Julie A. Segre, Ph.D. (NHGRI)
  • Human lung cancer microbiome signatures
    Curtis C. Harris, M.D. (NCI-CCR)
  • Healthcare personnel colonization with multidrug-resistant organisms
    Tara N. Palmore, M.D. (NIAID)
  • Oral microbiome as a trigger for immunopathology
    Niki Mousopoulos, D.D.S, Ph.D. (NIDCR)
  • FARE award winner, Oral microbiome as a trigger for immunopathology
    Dennise A. de Jesus Diaz (NIAID)

Lasting legacies: long-term effects of early developmental exposure

12:30 p.m. – 2:30 p.m.

FAES Classrooms 1-4

Chair: Carmen J. Williams, M.D., Ph.D. (NIEHS)

It is increasingly apparent that environmental exposures, particularly during developmentally sensitive time windows, can impact on later health outcomes in children and adults. Although this was a novel idea that encountered widespread skepticism when first proposed more than 25 years ago, it is now generally accepted due to robust documentation of these effects in both animal models and humans. Now known as DOHaD (Developmental Origins of Health and Disease), the field is moving toward defining the mechanisms by which early exposures modulate long-term physiology. This symposium will group intramural investigators from several ICs to highlight new evidence for DOHaD in human health outcomes as well as current data regarding the underlying mechanisms.

  • Parental obesity, inflammation and early childhood development|
    Edwina Yeung, Ph.D. (NICHD)
  • Preconception, prenatal and early childhood radiation exposure and risk of pediatric cancer
    Martha S. Linet, M.D., M.P.H. (NCI-DCEG)
  • Impact of abnormal maintenance of epigenetic structures on developmental disorders and age-related diseases
  • Bruce Howard, Ph.D. (NICHD)
  • FARE award winner, The enzymes of the O-GlcNAc cycling: writers AND readers of the histone code?
    Katryn Harwood, Ph.D. (NIDDK)
  • Developmental estrogen exposure alters adult reproductive tract function: epigenetic mechanisms
    Carmen J. Williams, M.D., Ph.D. (NIEHS)

Thursday, September 15, 2016

Rings of fire: Inflammation at the intersection of chronic disease

1:30 p.m. – 3:30 p.m.

Masur Auditorium

Chair: Thomas A. Wynn, Ph.D. (NIAID)

Inflammation is a complex biological response that occurs in all tissues of the body, typically in response to harmful stimuli (pathogens or irritants) or after repeated mechanical injury. Genetics also plays an important role. Although inflammation can be a protective response, if the causative agent is persistent or the mechanisms that regulate the initiation, maintenance, or resolution of the inflammatory response become dysregulated, inflammation can evolve into a pathophysiological response as is seen in chronic autoimmune, neurodegenerative, fibrotic, and allergic diseases. Inflammation also promotes some cancers. This workshop will highlight research conducted at the NIH that is helping to uncover the mechanisms by which chronic inflammation contributes to the development of disease.

  • Staphylococcus aureus and skin inflammation
    Keisuke (Chris) Nagao, M.D., Ph.D (NCI-CCR)
  • A novel model of macular edema using induced pluripotent stem cells and microfluidics
    Kapil Bharti, Ph.D. (NEI)
  • Metabolic events control T cell immunity and inflammation in liver cancer
    Tim F. Greten, M.D. (NCI-CCR)
  • Combating rebound inflammation to improve anti-fibrotic therapy
    Thomas A. Wynn, Ph.D. (NIAID)
  • FARE award winner, MYD88-dependent dendritic and epithelial cell crosstalk in the lung orchestrates immune responses to inhaled allergens
    Seddon Thomas, Ph.D. (NIEHS)

Precision medicine now: the power of NIH patient cohorts to wed genotype with phenotype

1:30 p.m. – 3:30 p.m.

Lipsett Amphitheater

Chair: Richard M. Siegel, M.D., Ph.D. (NIAMS)

Traditionally, medicine has defined diseases by their phenotype, and then investigated genetic causes of disease, but advances the sequencing of the human genome and DNA sequencing technology have opened up opportunities for a new approach where genetic mutations or polymorphisms are ascertained primarily, and their impact on disease risk and progression are then investigated. In this session, advances using this approach across a wide range of disease areas in the NIH intramural research program will be presented.

  • TNF family cytokines: from genotype to risk for autoimmune and inflammatory diseases
    Richard M. Siegel, M.D., Ph.D. (NIAMS)
  • Genomic prediction is foundational to precision medicine
    Leslie Biesecker, M.D. (NHGRI)
  • Ubiquitination meets Autoinflammation: insights from the NIH Autoinflammatory disease cohort
    Ivona Aksentijevich, M.D. (NHGRI)
  • ClinOmics; genome guided precision therapeutics for patients with cancer
    Javed Khan, M.D. (NCI-CCR)
  • FARE Award Winner, Polymorphisms in the promoter of the circadian rhythm gene Arntl2 affect metastatic susceptibility in breast cancer 
    Ngoc-Han Ha, Ph.D. (NCI-CCR)

Making sense of Greek letters and too many numbers in the age of big data

1:30 p.m. – 3:30 p.m.

FAES Classrooms 1-4

Chair: Stephen J. Chanock, M.D. 

Symposia description forthcoming

  • Mechanism and self-organization of membrane proteins insights from integrative modeling and molecular simulation
    José D. Faraldo-Gómez, Ph.D. (NHLBI)
  • Somatic genomic landscape of lung adenocarcinoma and its association with clinical features
    Jianxin Shi, Ph.D. (NCI-DCEG)
  • Redundancy: a critical obstacle to improving cancer therapy
    Orit Lavi, Ph.D. (NCI-CCR)
  • FARE Award Winner, Early Adulthood Adiposity, Life Course Trajectories of Adiposity, Weight Change, and Change and Esophageal and Gastric Cardia Adenocarcinoma Risk: A Pooled Analysis of NIH-AARP and PLCO Studies 
    Jessica Petrick, Ph.D. (NCI-DCEG)