Concurrent Symposia Sessions

• Wednesday, September 14, 2016
• Thursday, September 15, 2016

Wednesday, September 14, 2016

Chair: John I. Gallin, M.D. (CC) and Constantine A. Stratakis, M.D., D(Med)Sc (NICHD)

Since 1953, the NIH Clinical Center has been home to many great stories that took an idea from the bench to the bedside with tremendous successes as a result. Many (and likely most) of these clinical research discoveries could not have happened as easily anywhere else. This symposium serves to remind intramural colleagues of the rich portfolio of investigators who have hit home run research successes in the Clinical Center. These zealous research teams covered all bases in the lab, and with our patient partners, crossed the home plate in glory! Come hear the amazing lineup of these superstar hitters and, as we prepare for the session, follow us on Twitter: @NIHClinicalCntr!

• Prostate cancer imaging and targeted biopsies: opportunities to improve diagnosis and treatment
  Peter Pinto, M.D. (NCI-CCR)
• Stable isotope breath testing to assess in vivo metabolite flux in methylmalonic acidemia: From mouse models to patients
  Irini Manoli, M.D., Ph.D. (NHGRI) and Charles P. Venditti M.D., Ph.D. (NHGRI)
• Antioxidant therapy in RYR1-related myopathies
  Katherine Meilleur, Ph.D., PPCNP-BC (NINR)
• The Melanocortin 3 Receptor and Pediatric Obesity: From Bench to Bedside
  Jack A. Yanovski, M.D., Ph.D. (NICHD)
• FARE award winner, Quantitative high-throughput screening as a tool to identify novel therapies in Bladder Cancer: Lessons from Flavopiridol
  Reema S. Railkar, Ph.D. (NCI-CCR)

Chair: Julie A. Segre, Ph.D. (NHGRI)

Scientific studies have transformed our thinking of all microbes as enemies to highlight the fundamental roles that human-associated microbes play in promoting health throughout a lifetime. The bacteria, fungi, viruses, and archaea that reside in and on the human body constitute our microbiota, and their genes are our microbiome. In this session, we discuss studies exploring human-associated microbial communities to understand the etiology the disease and design interventions to promote health and treat disease.

• Genomic sequencing and analysis advances in Skin Microbiome Studies
  Julie A. Segre, Ph.D. (NHGRI)
• Human lung cancer microbiome signatures
  Curtis C. Harris, M.D. (NCI-CCR)
• Healthcare personnel colonization with multidrug-resistant organisms
  Tara N. Palmore, M.D. (NIAID)
• Oral microbiome as a trigger for immunopathology
  Niki Mousopoulos, D.D.S, Ph.D. (NIDCR)
• FARE award winner, Oral microbiome as a trigger for immunopathology
  Dennise A. de Jesus Diaz (NIAID)

Chair: Carmen J. Williams, M.D., Ph.D. (NIEHS)

It is increasingly apparent that environmental exposures, particularly during developmentally sensitive time windows, can impact on later health outcomes in children and adults. Although this was a novel idea that encountered widespread skepticism when first proposed more than 25 years ago, it is now generally accepted due to robust documentation of these effects in both animal models and humans. Now known as DOHaD (Developmental Origins of Health and Disease), the field is moving toward defining the mechanisms by which early exposures modulate long-term physiology. This symposium will group intramural investigators from several ICs to highlight new evidence for DOHaD in human health outcomes as well as current data regarding the underlying mechanisms.

• Parental obesity, inflammation and early childhood development|
  Edwina Yeung, Ph.D. (NICHD)
• Preconception, prenatal and early childhood radiation exposure and risk of pediatric cancer
  Martha S. Linet, M.D., M.P.H. (NCI-DCEG)
• Impact of abnormal maintenance of epigenetic structures on developmental disorders and age-related diseases
  Bruce Howard, Ph.D. (NICHD)
• FARE award winner, The enzymes of the O-GlcNAc cycling: writers AND readers of the histone code?
  Katryn Harwood, Ph.D. (NIDDK)
• Developmental estrogen exposure alters adult reproductive tract function: epigenetic mechanisms
  Carmen J. Williams, M.D., Ph.D. (NIEHS)

Thursday, September 15, 2016

Chair: Thomas A. Wynn, Ph.D. (NIAID)

Inflammation is a complex biological response that occurs in all tissues of the body, typically in response to harmful stimuli (pathogens or irritants) or after repeated mechanical injury. Genetics also plays an important role. Although inflammation can be a protective response, if the causative agent is persistent or the mechanisms that regulate the initiation, maintenance, or resolution of the inflammatory response become dysregulated, inflammation can evolve into a pathophysiological response as is seen in chronic autoimmune, neurodegenerative, fibrotic, and allergic diseases. Inflammation also promotes some cancers. This workshop will highlight research conducted at the NIH that is helping to uncover the mechanisms by which chronic inflammation contributes to the development of disease.

• Staphylococcus aureus and skin inflammation
  Keisuke (Chris) Nagao, M.D., Ph.D (NCI-CCR)
• A novel model of macular edema using induced pluripotent stem cells and microfluidics
  Kapil Bharti, Ph.D. (NEI)
• Metabolic events control T cell immunity and inflammation in liver cancer
  Tim F. Greten, M.D. (NCI-CCR)
• Combating rebound inflammation to improve anti-fibrotic therapy
  Thomas A. Wynn, Ph.D. (NIAID)
• FARE award winner, MYD88-dependent dendritic and epithelial cell crosstalk in the lung orchestrates immune responses to inhaled allergens
  Seddon Thomas, Ph.D. (NIEHS)

Chair: Richard M. Siegel, M.D., Ph.D. (NIAMS)

Traditionally, medicine has defined diseases by their phenotype, and then investigated genetic causes of disease, but advances the sequencing of the human genome and DNA sequencing technology have opened up opportunities for a new approach where genetic mutations or polymorphisms are ascertained primarily, and their impact on disease risk and progression are then investigated. In this session, advances using this approach across a wide range of disease areas in the NIH intramural research program will be presented.

• TNF family cytokines: from genotype to risk for autoimmune and inflammatory diseases
  Richard M. Siegel, M.D., Ph.D. (NIAMS)
• Genomic prediction is foundational to precision medicine
  Leslie Biesecker, M.D. (NHGRI)
• Ubiquitination meets Autoinflammation: insights from the NIH Autoinflammatory disease cohort
  Ivona Aksentijevich, M.D. (NHGRI)
• ClinOmics; genome guided precision therapeutics for patients with cancer
  Javed Khan, M.D. (NCI-CCR)
• FARE Award Winner, Polymorphisms in the promoter of the circadian rhythm gene Arntl2 affect metastatic susceptibility in breast cancer
  Ngoc-Han Ha, Ph.D. (NCI-CCR)

Chair: Stephen J. Chanock, M.D.

Symposia description forthcoming

• Mechanism and self-organization of membrane proteins insights from integrative modeling and molecular simulation
  José D. Faraldo-Gómez, Ph.D. (NHLBI)
• Somatic genomic landscape of lung adenocarcinoma and its association with clinical features
  Jianxin Shi, Ph.D. (NCI-DCEG)
• Redundancy: a critical obstacle to improving cancer therapy
  Orit Lavi, Ph.D. (NCI-CCR)
• FARE Award Winner, Early Adulthood Adiposity, Life Course Trajectories of Adiposity, Weight Change, and Change and Esophageal and Gastric Cardia Adenocarcinoma Risk: A Pooled Analysis of NIH-AARP and PLCO Studies
  Jessica Petrick, Ph.D. (NCI-DCEG)

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