NIH Research Festival
Since 1953, the NIH Clinical Center has been home to many great stories that took an idea from the bench to the bedside with tremendous successes as a result. Many (and likely most) of these clinical research discoveries could not have happened as easily anywhere else. This symposium serves to remind intramural colleagues of the rich portfolio of investigators who have hit home run research successes in the Clinical Center. These zealous research teams covered all bases in the lab, and with our patient partners, crossed the home plate in glory! Come hear the amazing lineup of these superstar hitters and, as we prepare for the session, follow us on Twitter: @NIHClinicalCntr!
Chair: Julie A. Segre, Ph.D. (NHGRI)
Scientific studies have transformed our thinking of all microbes as enemies to highlight the fundamental roles that human-associated microbes play in promoting health throughout a lifetime. The bacteria, fungi, viruses, and archaea that reside in and on the human body constitute our microbiota, and their genes are our microbiome. In this session, we discuss studies exploring human-associated microbial communities to understand the etiology the disease and design interventions to promote health and treat disease.
FAES Classrooms 1-4
Chair: Carmen J. Williams, M.D., Ph.D. (NIEHS)
It is increasingly apparent that environmental exposures, particularly during developmentally sensitive time windows, can impact on later health outcomes in children and adults. Although this was a novel idea that encountered widespread skepticism when first proposed more than 25 years ago, it is now generally accepted due to robust documentation of these effects in both animal models and humans. Now known as DOHaD (Developmental Origins of Health and Disease), the field is moving toward defining the mechanisms by which early exposures modulate long-term physiology. This symposium will group intramural investigators from several ICs to highlight new evidence for DOHaD in human health outcomes as well as current data regarding the underlying mechanisms.
Chair: Thomas A. Wynn, Ph.D. (NIAID)
Inflammation is a complex biological response that occurs in all tissues of the body, typically in response to harmful stimuli (pathogens or irritants) or after repeated mechanical injury. Genetics also plays an important role. Although inflammation can be a protective response, if the causative agent is persistent or the mechanisms that regulate the initiation, maintenance, or resolution of the inflammatory response become dysregulated, inflammation can evolve into a pathophysiological response as is seen in chronic autoimmune, neurodegenerative, fibrotic, and allergic diseases. Inflammation also promotes some cancers. This workshop will highlight research conducted at the NIH that is helping to uncover the mechanisms by which chronic inflammation contributes to the development of disease.
Chair: Richard M. Siegel, M.D., Ph.D. (NIAMS)
Traditionally, medicine has defined diseases by their phenotype, and then investigated genetic causes of disease, but advances the sequencing of the human genome and DNA sequencing technology have opened up opportunities for a new approach where genetic mutations or polymorphisms are ascertained primarily, and their impact on disease risk and progression are then investigated. In this session, advances using this approach across a wide range of disease areas in the NIH intramural research program will be presented.
FAES Classrooms 1-4
Chair: Stephen J. Chanock, M.D.
Symposia description forthcoming
This page was last updated on Friday, March 12, 2021