NIH Research Festival
Chair: Lothar Hennighausen, Ph.D. (NIDDK)
Cas9 RNA-guided endonucleases have been repurposed from CRISPR adaptive immune systems in bacteria and archaea and hold great promise in basic and translational research. NIH researchers have made an impact in the development and application of CRISPR/Cas9 genome-editing technologies to investigate genetic circuitry in mammals and advance therapies for hematologic disease. A potential limitation for the clinical use of CRISPR-based therapeutics is the frequent introduction of large deletions as the result of double stranded DNA break caused by Cas9. Such limitations might be avoided by deaminase base editing, a newer form of genome editing, which directly converts target C•G base pairs to T•A, or target A•T base pairs to G•C, without inducing double-stranded DNA breaks. This symposium will cover a range of topics, from the identification of novel CRISPR-Cas systems to the application of advanced base editing in altering the mammalian genome. It is our goal to highlight innovative research that takes emerging technologies from early stages of development to their application in basic science and to medicine.
Myeloid malignancies, such as myelodysplastic syndromes and acute myeloid leukemia, are rare, often highly fatal, cancers of the blood cells. The ability to repeatedly access the predominant sites of disease (blood and bone marrow) has accelerated scientific research into these conditions, resulting in generation of knowledge that is often also applicable to more common, but harder to study, cancer types. The results of these research efforts have been quickly translated, placing myeloid malignancies at the cutting edge of “precision medicine” efforts. In this session, we will highlight the bedside-to-bench-and-back approach that investigators at the NIH intramural research program are taking to this diverse collection of diseases, focusing particularly on mechanistic understanding of genetic etiology and on immune-based and targeted approaches as novel therapy.
The vasculature is omnipresent, reaching, and interacting with all other organ systems. Vascular diseases are responsible for more than fifty percent of all deaths worldwide with a financial burden of more than $700 billion per year affecting particular lower and middle income populations. Metabolic alterations, systemic inflammation, and hemodynamic tensions, are some of the most important causes that trigger adaptive remodeling processes which may lead to vascular diseases. This symposium will highlight research conducted at the NIH that is helping to uncover the mechanisms by which acquired and genetic factors contributes to the development of vascular diseases.
FAES Classrooms 6–7
Chair: Sabarni K. Chatterjee, Ph.D., M.B.A.
The Technology Transfer session will focus on the role of Technology Transfer in building successful partnerships with the industry and extramural community. Scientists will share stories on successful collaborations between their laboratory and industry partners
1:30 p.m. – 2:30 p.m. – Role of technology transfer: who we are and what we do
Michael Salgaller, Ph.D., Technology Transfer Center, NCI
Sue Ano, Ph.D. Office of Technology Transfer, NINDS
Steve Ferguson, M.B.A., Office of Technology Transfer, OD/NIH
2:30 p.m. – 3:30 p.m. – Panel on technology transfer success stories: successful collaborations and partnerships
Moderator: Thomas Stackhouse, Ph.D. Associate Director, TTC, NCI
Mitchell Ho, Ph.D.
James W. Hodge, Ph.D., M.B.A.
Malcolm Smith, M.D., Ph.D.
Co-Chairs: Matthew Guay, Ph.D. (NIBIB) and Eytan Ruppin, M.D., Ph.D. (NCI-CCR)
As technological advances enable the collection of more and more data across biomedical domains, researchers must process and find structure in big datasets in order to make full use of their analytical tools. Now, research groups in several NIH institutes are working to develop and apply new machine learning techniques to challenging data analysis problems. In this symposium, four groups will discuss their biomedical machine learning projects. A fifth presentation will share the results of the NIH Research Festival Hackathon, which brings teams together over the course of three days to tackle computational problems of interest to the NIH IRP.
Co-Chairs: Amy P. Hsu, B.A. (NIAID) and Matthew W. Kelley, Ph.D. (NIDCD)
High-throughput, next-generation sequencing (NGS) has allowed the expansion of nucleic-acid research from single, targeted, gene sequencing and transcript analysis, to in-depth investigation of the transcriptional profiles of single cells, detection and characterization of somatic mutations in cancer, and identification of novel disease genes in patients. This session aims to highlight intramural investigators who are using NGS as an integral part of their research program.
Chemistry is a powerful tool to probe biological processes and is the foundation on which many new therapies are derived. This session highlights the breadth of biology-including nucleic acid structure and function, amyloid formation, metastasis, cell transporters and HIV-that are being interrogated by intramural investigators using chemical methods.
This page was last updated on Monday, March 15, 2021