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NIH Research Festival

September 12 – 14, 2018

Estimating plasma glucose with FreeStyle Libre Pro CGM during OGTT in youth

Thursday, September 13, 2018 – Poster Session III
12:00 – 1:30 p.m.

FAES Terrace

NICHD

SYSBIO-1

Authors

  • N Ghane
  • MM Broadney
  • SM Collins
  • EK Davis
  • SM Brady
  • JA Yanovski

Abstract

Objective: To evaluate the accuracy and practicality of the FreeStyle Libre Pro (FLP) continuous glucose monitor (CGM) during oral glucose tolerance testing (OGTT) in a nondiabetic pediatric sample. Background: The FLP CGM has been found, in adults, to have acceptable accuracy compared to lab-measured glucose without patient calibration. No studies have assessed lab-measured glucose accuracy for this CGM in children. Hypothesis: FLP CGM glucose will not differ significantly from lab-measured plasma glucose during OGTT in youth. Methods: Healthy and overweight volunteers (n =8; 63% male), aged 7-11y wore FLP CGM for 6 days, with a 2-hour OGTT (1.75mg/kg, max 75g) on day 6. Laboratory (Cobas E6000, Roche) plasma glucose was measured at 30min intervals for 120min and compared with the simultaneously obtained CGM glucose values. AUC for CGM and lab-measured glucose were compared using paired t-tests. Correlation coefficients were calculated for each timepoint and potential systematic errors were examined using Bland-Altman analyses. Results: AUC for CGM and lab glucose were highly correlated (r= 0.91, p=0.006) and did not differ in mean value (p=0.84). CGM and lab glucose readings were not significantly different (all p’s>0.18). There were no systematic magnitude errors as assessed by Bland-Altman analyses. No adverse events occurred with CGM use. Conclusions: The FLP CGM device was well tolerated and, without patient mediated calibration, provided quantitatively similar glucose readings during OGTT for healthy weight and overweight children when compared to lab-measured glucose. This CGM may provide adjunctive data during evaluations of pediatric glucose excursions in clinical and research settings.

Scientific Focus Area: Systems Biology

This page was last updated on Friday, March 26, 2021

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