NIH Research Festival
Malaria is among the world’s most deadly diseases, but the mechanisms behind acquired immunity in adults remain poorly understood, slowing the progress towards a vaccine or new therapies. As part of a larger research effort, a prospective systems biology study of 80 children subject to seasonal malaria exposure in malaria-endemic Kalifabougou, Mali. Their responses to malaria exposure during the 2011 malaria season were explored using RNA-seq, antigen protein microarray, Luminex, FACS, ELISA and other assays. These results are now shared publicly using ImmPort, a database and analysis webportal for immunological experiment data developed by Northrop Grumman Information Technology Health Solutions for the NIH/NIAID/DAIT, where all or part of the data can be re-analyzed, data mined, or included in a meta-analysis with similar malaria data sets. A random forests data mining example reveals the features identified among all experiment types that best distinguish three stages of malaria resistance among the subjects.
Scientific Focus Area: Systems Biology
This page was last updated on Friday, March 26, 2021