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NIH Research Festival

September 12 – 14, 2018

Autophagy Pathway Protein Expression and Cellular Distribution in Oligodendrocyte Progenitor Cells

Friday, September 14, 2018 – Poster Session V
12:00 – 1:30 p.m.

FAES Terrace

NICHD

NEURO-4

Authors

  • J Belgrad
  • R De Pace
  • JS Bonifacino
  • RD Fields

Abstract

Hereditary spastic paraplegia (HSP) is a rare genetic disorder causing lower limb spasticity and paralysis in young children and progressing throughout adulthood. Classically defined as a motor neuron disease, the source of paralysis remains unknown. Here, were present the novel hypothesis that trophic support from myelinating glial cells, termed oligodendrocytes, contributes to HSP pathophysiology. In patients, mutations to autophagy-related protein Adaptor Protein 4 (AP-4) are frequently associated with HSP. Most recently, it has been found that AP-4 facilitates normal autophagy through the translocation of autophagy-related gene 9A (ATG9A) and notably, AP-4 KO animals display a thin myelin corpus callosum. To investigate the previously unexamined role of oligodendrocytes in HSP, we induced autophagy in wild-type oligodendrocyte progenitor cells. Our preliminary data reveals expression of autophagy pathway related proteins AP-4, ATG9A, and microtubule-associated protein 1A/1B-light chain 3 (LC3B) in oligodendrocyte progenitor cells following hypoxia and glucose starvation. Further, we present data suggesting autophagy is active during normal oligodendrocyte maturation and development in vitro. These findings indicate autophagy is an important, but largely overlooked, function in oligodendrocyte development, maturation, and myelination of axons. These studies will ultimately provide insight into our understanding of HSP and potential new interventions for patients.

Scientific Focus Area: Neuroscience

This page was last updated on Friday, March 26, 2021

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    • Special Wednesday Events
    • Vendor Exhibit Information
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    • NIH Early–Career Investigator Lectures
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    • General Schedule of Events
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    • Data Blitz
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    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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  • 2018
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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    • Plenary Sessions
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    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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