Biomarker detection using MALDI imaging

Authors

• J Hicks
• M Davisson
• H Kalish
• G Fabozzi
• C Petrovas

Abstract

Determining the location and relative concentrations of specific proteins within tissue samples is important to the biomedical community. Certain proteins, found in high concentrations, can be indicative of infected or diseased tissues. Matrix assisted laser desorption ionization (MALDI) mass spectrometry imaging is a new technique used to image proteins, peptides, and lipids found in tissue samples, with emphasis on spatial resolution. By using MALDI imaging in conjunction with other mass spectrometry instruments, our goal is to identify novel proteins, peptides, and lipids and confirm the presence of known biomarkers in infected tissues.

Scientific Focus Area: Immunology

This page was last updated on Friday, March 26, 2021