A method for the automated generation of patient-specific prostate molds for guided fresh tissue procurement and validating MRI lesion localization

Authors

• MA Garmendia
• RZ Freidlin
• CG Bastian
• JA Krynitsky
• TJ Pohida
• S Mehralivand
• MJ Merino
• PA Pinto
• PL Choyke
• IB Turkbey

Abstract

A method is introduced for the automated generation of patient-specific prostate molds for (1) guiding procurement of fresh tissue specimens and (2) validating lesion detection and localization on multi-parametric MRI with histopathology. The patient-specific mold is designed using 3D computer-rendered models of prostate gland, tumor, and urethra saved in Stereolithography (STLs) file format, volumes-of-interest (VOIs) files, and Digital Imaging and Communications in Medicine (DICOM) metadata information. An in-house script was developed in the 3D Computer-aided Design (CAD) software (SolidWorks) which automatically generates a 3D printable patient-specific mold that maintains the in-vivo orientation and shape of the gland to correctly align its pathology cutting slots with the in-vivo MRI imaging planes. Furthermore, a 3D printed locator card is generated to precisely identify the location of cancerous tissue regions, guided by the dedicated procurement cutting slot. Additionally, multiple channels are fabricated within the mold to guide biopsy needles. A 3D PDF assembly, consisted of the mold, prostate gland, tumor, urethra, procurement card and biopsy needle models, is generated for interactive visual guidance and spatial awareness to facilitate gland inspection and tissue procurement. The automation method decreases design time to less than 5 minutes, improves mold consistency, and reduces subjective workload.

Scientific Focus Area: Biomedical Engineering and Biophysics

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