ZIKV infection elicit mitochondria fragmentation
Wednesday, September 13, 2017 — Poster Session I
- S Yang
- K Gorshkov
- M Xu
- W Zheng
Zika virus (ZIKV) infects fetal and adult human brain and is associated with severe neurological complication, such as Guillain-Barré syndrome (GBS) and microcephaly. Mitochondria cycle of fission and fusion plays an important role in the many cellular functions and dictates bioenergetic functionality. There is mounting evidence that mitochondria dysfunction is correlated with the event in neurodegeneration. We found that ZIKV infection will elicit the changes in mitochondria that may link to its fission and fusion cycle. We are currently conducting more experiments to explore the mechanism of these changes caused by Zika virus infection. We are also looking for the potential compounds that may ameliorate the toxic effect on mitochondria caused by Zika virus infection.
Category: Cell Biology