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NIH Research Festival

September 13 – 15, 2017

Roles of Parkin and PINK1 in muscle damage and inflammation following exercise

Friday, September 15, 2017 – Poster Session IV
1:00 – 2:30 p.m.

FAES Terrace

NINDS

IMMUNO-19

Authors

  • DA Sliter
  • J Martinez
  • RJ Youle

Abstract

Whereas mutations in PINK1 and Parkin, which function together to clear damaged mitochondria, lead to early onset Parkinson’s disease (PD) in humans, Parkin-/- and PINK1-/- mice display no substantial PD-related phenotypes. We hypothesized that the sedentary environment of laboratory mice may mask underlying phenotypes and, therefore, utilized exhaustive exercise to stress mitochondria in vivo. Consistent with reports that mitochondrial stress or damage can directly initiate inflammation, we found that following exercise, Parkin-/- and PINK1-/- mice, but not WT mice, displayed dramatically elevated levels of inflammatory cytokines, increased body temperature and muscle damage. Concurrent deletion of STING, an innate immune receptor which responds downstream of cGAS, a sensor of mtDNA, or treatment with anti-IFNAR1 antibodies rescued the inflammatory response. Our data link the loss PINK1 and Parkin to STING-mediated inflammation following mitochondrial stress and, importantly, suggest that mitophagy may mitigate PD by removing damaged mitochondria and their DNA.

Scientific Focus Area: Immunology

This page was last updated on Friday, March 26, 2021

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Current Research Festival

  • 2025
  • 2024
    • General Schedule of Events
    • 2024 NIH Distinguished Scholars Program
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • National Academy of Science Mini-Symposium
    • Special Wednesday Events
    • Vendor Exhibit Information
    • Green Labs Fair
    • Research Festival Committee
  • 2023
    • General Schedule of Events
    • NIH Early–Career Investigator Lectures
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • Vendor Exhibit Information
    • Research Festival Committee
  • 2021
  • 2019
    • General Schedule of Events
    • Plenary Sessions
    • Poster Session
    • Data Blitz
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committee
  • 2018
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committees
  • 2017
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Future Research Leaders
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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    • General Schedule of Events
    • Plenary Sessions
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    • Future Research Leaders
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    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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