Circulating Inflammation Markers and Colorectal Cancer Risk: A Prospective Case-cohort Study in Japan

Authors

• M SONG
• S SASAZUKI
• MC CAMARGO
• T SHIMAZU
• TJ KEMP
• RM PFEIFFER
• A HILDESHEIM
• LA PINTO
• CS RABKIN
• S TSUGANE

Abstract

Background: Blood levels of inflammation-related markers may reveal molecular pathways contributing to carcinogenesis. To date, prospective associations with colorectal cancer (CRC) have been based on few studies with limited sets of analytes. Methods: We conducted a case-cohort study within the Japan Public Health Center-based Prospective Study Cohort II, comparing 457 incident CRC cases during median 18 years followup with a subcohort of 774 individuals. Baseline plasma levels of 72 cytokines, interleukins, soluble receptors, acute-phase proteins and metabolic markers were measured using Luminex bead-based assays. Cox proportional hazards models were used to estimate CRC hazard ratios (HRs) for quantiles of each marker. All analyses were stratified by age group and gender, adjusted for continuous age, geographic region, family history of CRC, history of diabetes, body mass index, smoking, alcohol and physical activity. Results: Of 64 detectable markers, linear trends in four C-C motif ligand (CCL) chemokines, one C-X-C motif ligand (CXCL) chemokines and a tumor necrosis factor receptor (TNFR) were significantly (p

Scientific Focus Area: Epidemiology

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