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Serum Metabolomic Profiling of All-Cause Mortality: A Prospective Analysis in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study Cohort

Thursday, September 14, 2017 — Poster Session III

12:00 p.m. – 1:30 p.m.
FAES Terrace
NCI
EPIG-14

Authors

  • J Huang
  • SJ Weinstein
  • SC Moore
  • A Derkach
  • X Hua
  • LM Liao
  • F Gu
  • AM Mondul
  • JN Sampson
  • D Albanes

Abstract

Background: Tobacco use, hypertension, hyperglycemia, overweight, and inactivity are leading causes of mortality worldwide, yet specific relevant metabolic alterations are largely unknown. Methods: We conducted a serum metabolomic analysis of 620 men in the ATBC Study. During 28 years of follow-up, there were 435 deaths, including 197 from cardiovascular disease (CVD) and 107 from cancer. The analysis included 406 known metabolites measured with ultra-high performance LC/MS and GC/MS. We used Cox regression to estimate mortality hazard ratios (HR) for a one standard-deviation (SD) difference in the metabolite-signal, subsequently divided the data into training and test sets, and used the former to create a metabolite risk score of the strongest metabolites (false discovery rate [FDR]< 0.1) to apply to the test-set. Results: The strongest associations with overall mortality were N-acetylvaline (HR=1.28; P

Category: Epidemiology