Plasma klotho, adiposity, and insulin resistance in older adults: findings from the InChianti Study

Authors

• MD Shardell
• RR Kalyani
• RD Semba
• S Bandinelli
• R Varadhan
• L Ferrucci

Abstract

Klotho is a recently discovered hormone with demonstrated anti-aging properties in animal studies. In older humans, evidence has linked plasma klotho with longevity. Insulin signaling is associated with longevity in animals and in humans, mediated in part by the accumulation of fat mass common in aging. Whether klotho is part of this longevity pathway is unknown. We hypothesize that plasma klotho is associated with insulin resistance and this association depends on by obesity status. Plasma klotho was measured in 832 participants aged = 55 years in InCHIANTI, a prospective cohort study comprising Italian adults. Insulin resistance was operationalized using the homeostasis model for insulin resistance (HOMA-IR). Body size was categorized using World Health Organization body mass index (BMI) categories (

Scientific Focus Area: Epidemiology

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