Quantifying systemic inflammation and its association with sagittal abdominal diameter in US adults

Authors

• A Amare
• SH Jackson

Abstract

Expending adiposity has been linked to chronic inflammation, which plays a central role in the progression of metabolic diseases such as diabetes. Using a novel systemic inflammation score (SIS) compiled from clinical laboratory test (race-specific quartiles for white blood cell ratios, albumin and gender-adjusted uric acid) we examined the association between systemic inflammation and sagittal abdominal diameter (SAD), an anthropologic measure of visceral obesity. We examined data from the 2011-12 National Health and Nutrition Examination Survey (NHANES) cohort, with 5720 respondents providing biological and survey data. Demographics, self-reported diabetic status and medication use, hemoglobin A1C, and 6 measures of allostatic load (AL; cholesterol, blood pressure, and waist circumference) were measured. Overall, 10%, 25% and 65% of the sample were diabetic, prediabetic and non-diabetic, with mean SIS of 5.6±0.10, 5.3±0.06, 5.03±0.04, respectively. Irrespective of diabetes status, mean SIS varied significantly across sex (males >female, p

Scientific Focus Area: Epidemiology

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