Thyroid hormone effects on lipid panel based on NMR LipoProfile 4 in patients with insulin receptor mutations

Authors

• PD Kothari
• Y Kushchayeva
• M Startzell
• E Cochran
• R Shamburek
• T Lin
• P Gorden
• RJ Brown

Abstract

Background: Lipoprotein particles are a heterogeneous mixture of particles that vary by size, density, and atherogenic effect. High density lipoprotein particles (HDL) are associated with cardioprotective effects, while low density lipoprotein particles (LDL) are associated with increased risk of cardiovascular disease. Emerging evidence indicates that particle size affects lipoprotein particle atherogenicity, with smaller particles being more harmful. Thyroid Hormones (TH) are known regulators of lipid metabolism, however the exact effect of TH status on HDL and LDL is yet unknown. Thus, we used data from an ongoing project focused on TH treatment of insulin resistance in patients with insulin receptor mutations to assess the short-term effects of TH on lipoprotein profiles during the transition from euthyroid to hyperthyroid states. Methods: Lipoprotein particle profiles were analyzed using NMR LipoProfile 4 prior to, at the start of, and after 1 and 2 weeks of treatment with Triiodothyronine (active TH). Results: Over two weeks, average HDL and LDL concentrations decreased from 673.3±96.4 to 654.5±70.1 umol/L (p

Scientific Focus Area: Molecular Pharmacology

This page was last updated on Friday, March 26, 2021