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NIH Research Festival

September 13 – 15, 2017

Manipulating the ovarian cancer metallome

Thursday, September 14, 2017 – Poster Session III
12:00 – 1:30 p.m.

FAES Terrace

NIMHD

MOLBIO-16

Authors

  • L Amable
  • E Shide

Abstract

The cellular metallome serves as an important reservoir to meet the biological needs of the cell. Recent studies have suggested that cancer cells adapt their metallome to accommodate rapid cellular growth and metabolism pathways. Thus, altering the cancer metallome may yield new avenues to target cancer and chemotherapy responsiveness. Here, we took a systematic approach to characterize the cellular metallome, as well as other cellular responses, under various metal conditions in a panel of ovarian cancer and non-cancer cell lines. In addition, sensitivity to the metal-based chemotherapy drug cisplatin in response to metal treatment was evaluated. The metallome was manipulated by treating cells with either zinc, copper, magnesium, calcium, iron, manganese, or the metal chelator tetrathiomolybdate. Cell proliferation in response to metal treatment or cisplatin was measured by WST-1 assays. Metallomes were quantitated by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) by measuring the following metals: zinc, copper, magnesium, calcium, molybdenum, manganese, iron, phosphorous, and sulfur. Cellular metal concentrations were normalized to sulfur levels. Metal treatment of ovarian cancer cells resulted in differences in cellular proliferation, uptake, and the cellular metallome. The changes in the metallome were not singular in nature as altering one metal resulted in changes in multiple metals. In terms of cisplatin sensitivity, the results suggest that metal alteration was only effective in certain cell lines. The data lend further insight into how an individual’s metallomic status, a combination of nutritional and harmful metal exposure, might result in the development and progression of cancer.

Scientific Focus Area: Molecular Biology and Biochemistry

This page was last updated on Friday, March 26, 2021

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Current Research Festival

  • 2025
  • 2024
    • General Schedule of Events
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    • National Academy of Science Mini-Symposium
    • Special Wednesday Events
    • Vendor Exhibit Information
    • Green Labs Fair
    • Research Festival Committee
  • 2023
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    • NIH Early–Career Investigator Lectures
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    • Vendor Exhibit Information
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    • General Schedule of Events
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    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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    • General Schedule of Events
    • Plenary Sessions
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    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Future Research Leaders
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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