Aortic Vascular Inflammation by FDG PET/CT is Associated with Coronary Non-Calcified Plaque in Psoriasis

Authors

• AD Belur
• A Goyal
• AA Joshi
• AK Dey
• JA Rodante
• JH Chung
• AA Sajja
• YA Elnabawi
• N Nanda
• MP Playford
• NN Mehta

Abstract

Psoriasis is a chronic inflammatory condition associated with increased cardiovascular risk and impaired vascular function. Patients with psoriasis have increased aortic vascular inflammation (VI) by 18-FDG PET/CT when compared to non-psoriatic controls. Plaque characterization on coronary CT angiography (CCTA) permits measurement of total plaque (TB) and non-calcified plaque (NCB) which has been strongly associated with future risk of MI. A comparative relationship between aortic VI and NCB in psoriatic patients and non-psoriatic controls is poorly characterized. Psoriatic patients and healthy controls underwent 18-FDG PET/CT (psoriasis n=215, control n=63) and CCTA scans (psoriasis n=182, control n=57). The psoriatic group had low risk of cardiovascular disease by Framingham Risk Score, as did controls (Median [IQR]: 3 [1-6] vs 1 [1-2], p

Scientific Focus Area: Epidemiology

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