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Aortic Vascular Inflammation by FDG PET/CT is Associated with Coronary Non-Calcified Plaque in Psoriasis

Thursday, September 14, 2017 — Poster Session III

12:00 p.m. – 1:30 p.m.
FAES Terrace
NHLBI
EPIG-16

Authors

  • AD Belur
  • A Goyal
  • AA Joshi
  • AK Dey
  • JA Rodante
  • JH Chung
  • AA Sajja
  • YA Elnabawi
  • N Nanda
  • MP Playford
  • NN Mehta

Abstract

Psoriasis is a chronic inflammatory condition associated with increased cardiovascular risk and impaired vascular function. Patients with psoriasis have increased aortic vascular inflammation (VI) by 18-FDG PET/CT when compared to non-psoriatic controls. Plaque characterization on coronary CT angiography (CCTA) permits measurement of total plaque (TB) and non-calcified plaque (NCB) which has been strongly associated with future risk of MI. A comparative relationship between aortic VI and NCB in psoriatic patients and non-psoriatic controls is poorly characterized. Psoriatic patients and healthy controls underwent 18-FDG PET/CT (psoriasis n=215, control n=63) and CCTA scans (psoriasis n=182, control n=57). The psoriatic group had low risk of cardiovascular disease by Framingham Risk Score, as did controls (Median [IQR]: 3 [1-6] vs 1 [1-2], p

Category: Epidemiology