Biomarker Detection Using MALDI Imaging

Authors

• M Davisson
• G Fabozzi
• C Petrovas
• H Kalish

Abstract

Determining the location and relative concentrations of specific proteins within tissue samples is important to the biomedical community. Certain proteins, found in high concentrations, can be indicative of infected or diseased tissues. Confocal microscopy has been used to image target proteins in tissues using fluorescent dye and antibodies, but this technique is limited by advance knowledge of proteins in the sample. Matrix assisted laser desorption ionization (MALDI) mass spectrometry imaging is a new technique used to image proteins, peptides and lipids found in tissue samples. By using MALDI mass spectrometry in tandem with confocal microscopy, our goal is to identify new biomarkers of interest and to confirm the presence of known biomarkers in infected tissues.

Scientific Focus Area: Immunology

This page was last updated on Friday, March 26, 2021