Serum caffeine metabolites along with cysteine, 2-oxoarginine, argininate, alpha-ketoglutarate, and chenodeoxycholate associated with glioma risk up to 26 years prior to diagnosis

Authors

• J Huang
• SJ Weinstein
• CM Kitahara
• JN Sampson
• D Albanes

Abstract

Little is known about the etiology, early detection and potential prevention of malignant glioma. We conducted a prospective serum metabolomic analysis of 64 glioma cases and 64 matched controls from the ATBC Study cohort. Time from baseline fasting serum collection to diagnosis was 1-26 years (median 9 years). Ultra-high performance LC/MS identified 730 known metabolites, and conditional logistic regression estimated odds ratios (ORs) for 1-SD differences in metabolite signals on a log-scale. Forty-three metabolites were associated with risk of glioma at p

Scientific Focus Area: Epidemiology

This page was last updated on Friday, March 26, 2021