NIH Research Festival
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FAES Terrace
NCI
EPIG-13
Little is known about the etiology, early detection and potential prevention of malignant glioma. We conducted a prospective serum metabolomic analysis of 64 glioma cases and 64 matched controls from the ATBC Study cohort. Time from baseline fasting serum collection to diagnosis was 1-26 years (median 9 years). Ultra-high performance LC/MS identified 730 known metabolites, and conditional logistic regression estimated odds ratios (ORs) for 1-SD differences in metabolite signals on a log-scale. Forty-three metabolites were associated with risk of glioma at p
Scientific Focus Area: Epidemiology
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