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NIH Research Festival

September 13 – 15, 2017

STAT1 dependent interferon-related DNA damage resistance signature (IRDS) is a survival mechanism in castrate resistant prostate cancer (CRPC)

Friday, September 15, 2017 – Poster Session IV
1:00 – 2:30 p.m.

FAES Terrace

NCI

CANCER-9

Authors

  • S AGARWAL
  • K McGowen
  • K Kelly

Abstract

Contrary to the anti-proliferative interferon (IFN) signaling, IFN related DNA damage resistance signature (IRDS) has pro-survival function and is responsible for cancer cell intrinsic therapy resistance. This signature encompasses a subset of STAT1-driven genes that have been associated with breast cancer therapy resistance. Interestingly, our RNAseq analysis of organoids from FACS-sorted Pten/Tp53-null PCa luminal progenitors have revealed a robust IRDS expression. Based on our previous findings that the luminal progenitors display intrinsic resistance to androgen deprivation therapy (ADT), we hypothesized that the IRDS expression might in part account for survival of PCa cells following ADT or genotoxic therapies. Our analysis of human PCa datasets revealed IRDS as a prognostic marker for progression in the TCGA primary PCa cohort (p

Scientific Focus Area: Cancer Biology

This page was last updated on Friday, March 26, 2021

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Current Research Festival

  • 2025
  • 2024
    • General Schedule of Events
    • 2024 NIH Distinguished Scholars Program
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • National Academy of Science Mini-Symposium
    • Special Wednesday Events
    • Vendor Exhibit Information
    • Green Labs Fair
    • Research Festival Committee
  • 2023
    • General Schedule of Events
    • NIH Early–Career Investigator Lectures
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • Vendor Exhibit Information
    • Research Festival Committee
  • 2021
  • 2019
    • General Schedule of Events
    • Plenary Sessions
    • Poster Session
    • Data Blitz
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committee
  • 2018
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committees
  • 2017
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Future Research Leaders
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committees
  • 2016
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • Browse by Presenter Name
    • Browse by Presenter IC
    • FARE Award Ceremony
    • Future Research Leaders
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Tours of the National Library of Medicine and Clinical Center
    • Research Festival Committees
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    • Plenary Sessions
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