Cutting edge photon counting CT facility at NIH: engaging extramural academic partners and promotion of cross disciplinary intramural team science

Authors

• EC Jones
• P Sahbaee
• WF Pritchard
• AA Malayeri
• A Samei
• BJ Wood

Abstract

Advanced x-ray detector technology has enabled the application of photon-counting technology to clinical CT imaging. The NIH Clinical Center acquired one of two Siemens clinical prototype photon counting CT (PCCT) systems in the world through a CRADA; the second resides at Mayo Clinic. In addition to potential radiation dose reduction, the unique physics of PCCT allows increased spatial resolution, reduced noise and detection of different photon energies. We have established a collaborative group to advance the basic science of PCCT and clinical investigations into new and enhanced diagnostic applications. Along with the Clinical Center investigators and clinicians, we have established basic science collaborations with the Duke Advanced Imaging Laboratory and the Mayo Clinic PCCT site. Proposed clinical projects build on foundational basic science projects in imaging physics with a bridge to clinical applications. These may be grouped into three general areas with multiple proposed projects within each area A. Clinical optimization: Study the optimal balance of image quality, resolution, noise and dose reduction. B. Studies related to improved resolution with PCCT: These include preclinical models and clinical characterization of thoracic and abdominal disease processes and tumors, including radiogenomics. C. Spectral CT: Leveraging ability to detect different energy level photons. Projects include bone marrow assessment for metastases and marrow occupying processes; detection and quantification of different absorbers: new contrast agents and image-able embolic beads. In summary, the collaborations of this diverse group of PCCT investigators across NIH and with other institutions is in keeping with the theme of team collaborative science.

Scientific Focus Area: Biomedical Engineering and Biophysics

This page was last updated on Friday, March 26, 2021