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NIH Research Festival

September 13 – 15, 2017

Preclinical pharmacokinetic of a lead peptide for bronchopulmonary dysplasia prevention

Friday, September 15, 2017 – Poster Session IV
1:00 – 2:30 p.m.

FAES Terrace

NCATS

PHARM-1

Authors

  • KM Konrath
  • MD Singleton
  • AQ Wang
  • X Xu

Abstract

Bronchopulmonary dysplasia (BPD) is a complication developed by many premature infants facing respiratory failure. The administration of a ventilator and the hypoxic conditions to treat preterm babies is thought to play a role in the development of BPD. The inflammatory response from these conditions results in abnormal vascular and alveolar development which can lead to mortality as well as long-term neurological and respiratory effects. Current treatment for BPD is corticosteroids which has limited success. There is not currently a known preventative treatment for BPD. As such, NCATS is working with Novare on developing a preventative therapeutic peptide that acts to block the inflammatory response implicated in the development of BPD. The purpose of current study is to assess the stability of the lead peptide in mouse and baboon blood and plasma in order to develop the sample collection procedure for pharmacokinetic (PK) and PK/PD studies and to evaluate pharmacokinetic properties of the lead peptide in preclinical studies.

Scientific Focus Area: Molecular Pharmacology

This page was last updated on Friday, March 26, 2021

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Current Research Festival

  • 2025
  • 2024
    • General Schedule of Events
    • 2024 NIH Distinguished Scholars Program
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  • 2023
    • General Schedule of Events
    • NIH Early–Career Investigator Lectures
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    • Concurrent Workshops
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    • Vendor Exhibit Information
    • Research Festival Committee
  • 2021
  • 2019
    • General Schedule of Events
    • Plenary Sessions
    • Poster Session
    • Data Blitz
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committee
  • 2018
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