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September 9 – 12, 2025 | NIH Main Bethesda, Campus

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NIH Research Festival

September 23 – 25, 2024

Radiolabeling of peptides, nanobodies, and aptamers for positron emission tomography (PET)

Authors

  • D Kiesewetter
  • L Lang
  • J Gonzalez-Guzman

Abstract

Our NIBIB core facility has a mission to provide state of the art positron emission tomography imaging in small animals. Our equipment includes a Mediso nanoScan PET/CT instrument to provide high quality, quantitative images of radioisotope distribution in mice or rats. In addition, we have a radiochemistry facility to synthesize Ga-68, Cu-64 and F-18 labeled radiotracers. We now have available fluorine-18 labeled prosthetic groups that can be attached to peptides, nanobodies, and aptamers. Using copper-mediated radiofluorination of aryl boronates, we have prepared N-hydroxysuccinimidyl [18F]fluorobenzoate for attachment to lysine residues; 1-(3-(4-(4-[18F]fluorobenzyl)piperazin-1-yl)-3-oxopropyl)-1H-pyrrole-2,5-dione (a maleimide) for attachment to free cysteine thiol residues; and 2-azido-1(4-(4-[18F]fluorobenzylpiperazin-1-yl)ethan-1-one for attachment to alkyne residues using copper catalyzed “click” chemistry. The preparation methods for the various compounds utilize the same automated radiosynthesis system with only slight variations in purification conditions. These compounds can be conjugated to appropriate biomolecules and the resulting product used for PET/CT imaging.

Scientific Focus Area: Research Support Services

This page was last updated on Tuesday, August 6, 2024

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Current Research Festival

  • 2025
  • 2024
    • General Schedule of Events
    • 2024 NIH Distinguished Scholars Program
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • National Academy of Science Mini-Symposium
    • Special Wednesday Events
    • Vendor Exhibit Information
    • Green Labs Fair
    • Research Festival Committee
  • 2023
    • General Schedule of Events
    • NIH Early–Career Investigator Lectures
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • Vendor Exhibit Information
    • Research Festival Committee
  • 2021
  • 2019
    • General Schedule of Events
    • Plenary Sessions
    • Poster Session
    • Data Blitz
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committee
  • 2018
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committees
  • 2017
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Future Research Leaders
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committees
  • 2016
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • Browse by Presenter Name
    • Browse by Presenter IC
    • FARE Award Ceremony
    • Future Research Leaders
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Tours of the National Library of Medicine and Clinical Center
    • Research Festival Committees
  • 2015
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Workshop Sessions
    • Poster Sessions
    • Browse by Presenter Name
    • Browse by Presenter IC
    • FARE Award Ceremony
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    • Special Exhibits on Resources for Intramural Research
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