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NIH Research Festival

September 16 – 18, 2015

Ultrasmall Gold Nnaorod Vesicle with Enhanced Tumor Accumulation and Fast Excertion From the Body for Cancer Therapy

Thursday, September 17, 2015 – Poster Session II
12:00 – 1:30 p.m.

FAES Terrace

NIBIB

CANCER-3

Authors

  • XY Chen

Abstract

Gold nanorods (AuNRs) and their assemblies with optical absorption in the near-infrared (NIR) region have been widely used for bioimaging and photothermal cancer therapy. However, the commonly used AuNRs made by seed method usually have a width greater than 8 nm and length of about 40 nm, which have rapid reticuloendothelial system (RES) organ and tissue accumulation after intravenous administration and very slow clearance from the body. Herein, we report a new kind of small AuNRs (~8 × 2 nm) based on a seedless method, which are readily removed from the body by renal clearance. To increase the in vivo circulation time and tumor accumulation efficiency of the small AuNRs, a novel theranostic platform of biodegradable plasmonic AuNR vesicles with a size of ~60 nm was prepared by self-assembly of small amphiphilic AuNRs grafted with poly(ethylene glycol) (PEG) and poly(lactic-co-glycolic acid) (PLGA) (AuNR@PEG/PLGA) using an oil-in-water (O/W) emulsification method. The strong plasmonic coupling of AuNRs in the vesicular shell gives rise to high photothermal conversion efficiency and strong photoacoustic signal. Non-invasive positron emission tomography (PET) imaging demonstrated that the 64Cu-labeled vesicles can efficiently home to the tumor region after intravenous injection. Furthermore, complete tumor ablation was achieved using 808 nm NIR laser irradiation with low power density (0.4 W/cm2). The vesicles can be degraded into individual small AuNR@PEG, which are rapidly excreted from the body after exerting the photothermal effect in the tumor area.

Scientific Focus Area: Cancer Biology

This page was last updated on Friday, March 26, 2021

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Current Research Festival

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  • 2024
    • General Schedule of Events
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    • Special Wednesday Events
    • Vendor Exhibit Information
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  • 2023
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    • NIH Early–Career Investigator Lectures
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    • General Schedule of Events
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    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
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    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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  • 2017
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Future Research Leaders
    • Special Exhibits on Resources for Intramural Research
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  • 2016
    • General Schedule of Events
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    • Browse by Presenter Name
    • Browse by Presenter IC
    • FARE Award Ceremony
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    • Tours of the National Library of Medicine and Clinical Center
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  • 2015
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