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NIH Research Festival

September 16 – 18, 2015

TCF1 is required for the T follicular helper (TFH) cell response to viral infection

Thursday, September 17, 2015 – Poster Session III
3:30 – 5:00 p.m.

FAES Terrace

NHGRI

IMMUNO-40

FARE Award Winner

Authors

  • T Wu
  • H Shin
  • E Moseman
  • Y Ji
  • B Huang
  • J Sen
  • L Berg
  • L Gattinoni
  • D McGavern
  • P Schwartzberg

Abstract

TFH and Th1 cells generated after viral or intracellular bacterial infections are critical for the control of infections and the development of immunological memories. However, the mechanisms that govern the choice of activated CD4 T cells between the two alternative fates remain unclear. Here, we found that reciprocal expression of TCF1 and Blimp1 between viral-specific TFH and Th1 cells started early after infection. TCF1 was intrinsically required for the differentiation of TFH cells. In the absence of TCF1, TFH cells failed to maintain their transcriptional and metabolic signatures, which are distinct from those in Th1 cells. Mechanistically, TCF1 functioned through forming negative feedback loops with IL-2 and Blimp1. Thus, we have demonstrated an essential role of TCF1 in TFH-cell differentiation.

Scientific Focus Area: Immunology

This page was last updated on Friday, March 26, 2021

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Current Research Festival

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    • NIH Early–Career Investigator Lectures
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    • NIH Resource Information Fair
    • Vendor Exhibit Information
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  • 2021
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    • General Schedule of Events
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    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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