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NIH Research Festival

September 16 – 18, 2015

Overcoming resistance mechanisms in a study of cabozantinib (C) plus docetaxel (D) and prednisone (P) in metastatic castrate-resistant prostate cancer (mCRPC)

Thursday, September 17, 2015 – Poster Session II
12:00 – 1:30 p.m.

FAES Terrace

NCI

CANCER-14

Authors

  • FH Karzai
  • RA Madan
  • MR Theoret
  • PM Arlen
  • J Strauss
  • G Chun
  • A Couvillon
  • N Harold
  • C Chen
  • NA Dawson
  • SM Steinberg
  • JB Trepel
  • JJ Wright
  • DK Price
  • JL Gulley
  • WD Figg
  • WL Dahut

Abstract

D improves survival in mCRPC, but benefits are modest. Emerging clinical data suggests mCRPC patients (pts) treated with anti-androgen therapy like abiraterone (AA) or enzalutamide (ENZA) have decreased responses to susequent therapy with D due to cross-resistance in the androgen pathway targeted by D, AA, and ENZA(van Soest et al, Eur J Cancer 49:18, 2013). Patients (pts) with no prior history of D, receive D at 75 mg/m2 IV on day 1 of a 21 day cycle, and prednisone (P) at 5 mg po q12 hours, with C at three dose levels: 20 mg, 40 mg, or 60 mg po daily.19 pts have been accrued on phase I; 4 at 20 mg C, 8 at 40 mg C, and 7 at 60 mg C.On phase I, 13 patients previously treated with AA, the median potential follow up is 12.4 months. 9 month PFS is 60.5% (95% CI: 34.0%-82.0%).D plus P may have limited benefits after disease progression on AA as seen in 3 retrospective analyses demonstrating a median PFS of 4.6 months or less (Mezynski J, et al. Ann Oncol 23;11, 2012) (Aggarwal R, et al. Clin Genitourin Cancer 12;5, 2014) (Schweizer MT, et al. Eur Urol 66;4, 2014). PFS results seen in this trial compare favorably to historical data of treatment with D after progression on AA, suggesting the addition of C to D may help overcome acquired resistance.

Scientific Focus Area: Cancer Biology

This page was last updated on Friday, March 26, 2021

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2015 program

Download the 2015 Research Festival Schedule Overview (6 pages)

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Current Research Festival

  • 2025
  • 2024
    • General Schedule of Events
    • 2024 NIH Distinguished Scholars Program
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • National Academy of Science Mini-Symposium
    • Special Wednesday Events
    • Vendor Exhibit Information
    • Green Labs Fair
    • Research Festival Committee
  • 2023
    • General Schedule of Events
    • NIH Early–Career Investigator Lectures
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • Vendor Exhibit Information
    • Research Festival Committee
  • 2021
  • 2019
    • General Schedule of Events
    • Plenary Sessions
    • Poster Session
    • Data Blitz
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committee
  • 2018
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committees
  • 2017
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Future Research Leaders
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committees
  • 2016
    • General Schedule of Events
    • Plenary Sessions
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    • Poster Sessions
    • Browse by Presenter Name
    • Browse by Presenter IC
    • FARE Award Ceremony
    • Future Research Leaders
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    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Tours of the National Library of Medicine and Clinical Center
    • Research Festival Committees
  • 2015
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Workshop Sessions
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    • Browse by Presenter Name
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