Multivalent Display on Synthetic PNA Scaffolds

Authors

• KM George Rosenker
• AV Dix
• DH Appella

Abstract

Peptide nucleic acid (PNA) scaffolds represent a promising tool for the interrogation of the multivalent effects of ligand binding to a membrane receptor. Adenosine A2A and dopamine D2 receptors each represent a separate class of G protein-coupled receptors (GPCRs) known to modulate cognitive function. The abnormal formation of dimers and higher ordered structures of these membrane receptors has been associated with the progression of several neurological diseases. A highly programmable synthetic system for the multivalent display of small molecules has been developed to probe the multivalent profiles of the A2A and D2 receptors.

Scientific Focus Area: Chemical Biology

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