The Imaging Probe Development Center Makes All Types of Diagnostic Imaging Agents

Authors

• B Blackman
• F Bhattacharyya
• C Hitco
• AC Opina
• C Mushti
• D Sail
• ZD Shi
• H Wu
• B Xu
• V Coble
• K Lane
• X Zhang
• R Swenson

Abstract

The Imaging Probe Development Center (IPDC) was founded with the goal of providing the fundamental synthetic chemistry support needed to advance molecular imaging technologies for the interdisciplinary NIH research community. The IPDC laboratories are located in Rockville, Maryland, with state-of-the-art equipment and the new PET facility at the NIH main campus. The IPDC has a rolling solicitation system, and NIH scientists are welcome to contact us and submit a proposal requesting synthesis of a particular probe in which they are interested. Probes can be intended for all types of imaging modalities, such as optical fluorescence, PET/SPECT, and MRI. IPDC scientists can synthesize requested probes that are completely novel or that are published in literature but commercially unavailable. We look for automation solutions to improve capabilities and throughput. We have produced molecular imaging probes ranging from low-molecular-weight entities to high-molecular-weight conjugates, including fluorescent dyes and their analogs, lanthanide complexes, fluorogenic enzyme substrates, caged dyes that become fluorescent upon irradiation, radio- and fluorescent-labeled peptides, proteins and antibodies, gold and iron oxide nanoparticles, dendrimers, and liposomes. Recent efforts have included hyperpolarized MRI probes, tools for super-resolution spectroscopy, and PET probes derived from tyrosine kinase inhibitors. Examples of some of our recent projects will be provided.

Scientific Focus Area: Research Support Services

This page was last updated on Friday, March 26, 2021