Greater Insulin Resistance and Paradoxically Lower Postprandial Peak Glucose in Black Compared to White Women: The Federal Women Study

Authors

• PC Aldana
• CK Thoreson
• MT Duong
• M Ricks
• L Mabundo
• AE Sumner
• ST Chung

Abstract

Black women have greater hyperinsulinemia to oral and intravenous (IV) glucose compared to whites. It is unknown if these differences persist during a normal meal. We performed a mixed meal test (MMT), OGTT and FSIGT in 28 non-diabetic female federal employees (15 African American, 6 African, 7 white; age 46±8y (mean±SD); BMI 28±5kg/m2). Area under the curve (AUC) for insulin and C-peptide levels were used to quantify insulin response and hepatic insulin extraction (HIE) during the OGTT and MMT. Acute insulin response to IV glucose (AIRg) and insulin sensitivity index (SI) were calculated from the FSIGT. Black women had lower SI (3.1±0.8 vs. 5.5±2.2 mU/L-1.min-1, P

Scientific Focus Area: Health Disparities

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