A genome-wide association study using a custom genotyping array identifies variant in GPR158 associated with reduced energy expenditure and increased Body Mass Index in American Indians

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Authors

• P Piaggi
• I Masindova
• YL Muller
• GB Wiessner
• P Chen
• A Gale
• S Kobes
• RL Hanson
• C Bogardus
• LJ Baier

Abstract

A relatively lower energy expenditure (EE) predicts long-term increases in adiposity. Heritable factors explain 40-70% and 10% of the inter-individual variance in BMI and EE, respectively. The aim of this study was to identify genetic variants that reduce EE, thereby increasing BMI in Pima Indians, an ethnic group with a high prevalence of obesity. 521,709 Pima-specific tag SNPs (MAF≥5%) were genotyped using an Affymetrix Axiom Custom Array in 2762 full-heritage non-diabetic Pima Indians informative for maximum lifetime BMI and two separate measures of EE: resting metabolic rate (RMR) by a ventilated hood system (n=496) and 24h EE assessed in a whole-room calorimeter (n=406). Rs11014566 (A/G), which maps to an intron in GPR158, demonstrated one of the strongest associations with both EE measures (p

Scientific Focus Area: Genetics and Genomics

This page was last updated on Friday, March 26, 2021