Drug Combination Screening for Ewing’s Sarcoma

Authors

• MI Davis
• R Guha
• KM Wilson
• M Gormally
• P Shinn
• X Zhang
• S Michael
• C McKnight
• T Mierzwa
• P Meltzer
• F Arnaldez
• L Helman
• C Thomas

Abstract

Ewing’s sarcoma is a rare bone cancer that primarily affects individuals under the age of 30. Ewing’s sarcoma is treated with cytotoxic drug combinations, and there is a need for new treatment options. Four Ewing’s cell lines were screened against the 1912 small molecule compounds in the MIPE (mechanism interrogation plate) library. Inhibitors of cell viability were identified. Combinations of identified inhibitors were then screened together in a matrix format to look for synergistic and additive combinations. The screen identified several candidate combinations that exhibited synergistic behavior at multiple dose combinations and we report on follow up studies exploring these synergies in more detail.

Scientific Focus Area: Chemical Biology

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