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NIH Research Festival

September 16 – 18, 2015

Drug Combination Screening for Ewing’s Sarcoma

Thursday, September 17, 2015 – Poster Session II
12:00 – 1:30 p.m.

FAES Terrace

NCATS

CHEMBIO-3

Authors

  • MI Davis
  • R Guha
  • KM Wilson
  • M Gormally
  • P Shinn
  • X Zhang
  • S Michael
  • C McKnight
  • T Mierzwa
  • P Meltzer
  • F Arnaldez
  • L Helman
  • C Thomas

Abstract

Ewing’s sarcoma is a rare bone cancer that primarily affects individuals under the age of 30. Ewing’s sarcoma is treated with cytotoxic drug combinations, and there is a need for new treatment options. Four Ewing’s cell lines were screened against the 1912 small molecule compounds in the MIPE (mechanism interrogation plate) library. Inhibitors of cell viability were identified. Combinations of identified inhibitors were then screened together in a matrix format to look for synergistic and additive combinations. The screen identified several candidate combinations that exhibited synergistic behavior at multiple dose combinations and we report on follow up studies exploring these synergies in more detail.

Scientific Focus Area: Chemical Biology

This page was last updated on Friday, March 26, 2021

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2015 program

Download the 2015 Research Festival Schedule Overview (6 pages)

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Current Research Festival

  • 2025
  • 2024
    • General Schedule of Events
    • 2024 NIH Distinguished Scholars Program
    • Poster Sessions
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    • National Academy of Science Mini-Symposium
    • Special Wednesday Events
    • Vendor Exhibit Information
    • Green Labs Fair
    • Research Festival Committee
  • 2023
    • General Schedule of Events
    • NIH Early–Career Investigator Lectures
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • Vendor Exhibit Information
    • Research Festival Committee
  • 2021
  • 2019
    • General Schedule of Events
    • Plenary Sessions
    • Poster Session
    • Data Blitz
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committee
  • 2018
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
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    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committees
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    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Future Research Leaders
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    • FARE Award Ceremony
    • Future Research Leaders
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    • Research Festival Committees
  • 2015
    • General Schedule of Events
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