Biomedical Engineering and Physical Science Shared Resource

Authors

• HS Eden
• AJ Balbo
• EK Dimitriadis
• AM Gorbach
• HR Kalish
• NY Morgan
• G Zhang

Abstract

The Biomedical Engineering and Physical Science (BEPS) Shared Resource develops and applies novel research technologies in support of NIH intramural scientists. The technologies range in scale from near-atomic resolution to intact organisms. Examples include: 1) biophysical methods (analytical ultracentrifugation; circular dichroism; dynamic light scattering; microcalorimetry; force spectroscopy for single molecule recognition, protein unfolding and high resolution material characterization; surface plasmon resonance sensors; and mathematical modeling, etc.), 2) imaging techniques (atomic force microscopy; serial block-face imaging with scanning electron microscopy; transmission electron microscopy, including preparative techniques; electron tomography; and infrared/multispectral imaging of tissues and organs, including clinical imaging, etc.), 3) micro analytical chemistry (preparative immunochemical techniques, affinity and immunoaffinity analysis of sub-microliter samples; capillary electrophoresis with fluorescence detection; detection of analytes at femtogram and attogram levels, etc.); 4) microfabrication for biomedical applications (microfluidic devices, including rapid design/turnaround of templates down to ~2 µm dimensions; thin film fabrication, including spin coating polymers; surface modification of PDMS and other polymers, hydrogel patterning, and characterization of surfaces and devices, etc.). Please contact us for more information or to discuss potential projects: www.nibib.nih.gov/beps

Scientific Focus Area: Biomedical Engineering and Biophysics

This page was last updated on Friday, March 26, 2021