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NIH Research Festival

September 16 – 18, 2015

Apical resection mouse model to study early mammalian heart regeneration

Thursday, September 17, 2015 – Poster Session II
12:00 – 1:30 p.m.

FAES Terrace

NHLBI

DEVBIO-11

Authors

  • J Xiong

Abstract

Cardiovascular disease plagues the whole world due to intensive lifestyle changes. Heart regeneration holds great promise for repairing and restoring cardiomyocytes lost due to injury and disease. In contrast to the robust cardiac regeneration of certain lower vertebrates, adult mammalian hearts typically show minimal capacity for heart regeneration and repair. However, recent studies have sparked considerable scientific interest with the finding that, between postnatal day 1 to 7 (P1 to P7), the neonatal mouse heart retains significant regenerative potential after apical resection (i.e., surgical amputation and exposure of left ventricular apex). One major controversy over this finding might be due to the diverse surgery-related procedures used in efforts to replicate or expand upon this important finding. These instructions dynamically present the materials and methodology for apical resection in a mouse model. The salient steps of this rodent survival surgery involve hypothermia anesthesia, thoracotomy, surgical amputation of heart ventricular apex, and suture and recovery of mice. The approach described could expand the application of the apical resection mouse model for cardiovascular research.

Scientific Focus Area: Developmental Biology

This page was last updated on Friday, March 26, 2021

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Current Research Festival

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    • Vendor Exhibit Information
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    • General Schedule of Events
    • NIH Early–Career Investigator Lectures
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • Vendor Exhibit Information
    • Research Festival Committee
  • 2021
  • 2019
    • General Schedule of Events
    • Plenary Sessions
    • Poster Session
    • Data Blitz
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
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    • Future Research Leaders
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    • General Schedule of Events
    • Plenary Sessions
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    • Browse by Presenter Name
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    • FARE Award Ceremony
    • Future Research Leaders
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    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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    • Research Festival Committees
  • 2015
    • General Schedule of Events
    • Plenary Sessions
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