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NIH Research Festival

September 23 – 25, 2024

Vitamin E sequestration in MASLD and effect of supplementation in mitigating progression to MASH

Authors

  • TD Greene
  • S Teng
  • I Rozga
  • R Berman
  • N Munyan
  • I Ebenuwa
  • M Levine
  • PC Violet

Abstract

The global obesity epidemic has severe implications for human health, particularly the rise of metabolic dysfunction-associated steatotic liver disease (MASLD), leading cause of chronic liver disease. Studies have implicated dysregulation of the fat-soluble antioxidant vitamin E in pathogenesis of fatty liver disease. We hypothesized excess body fat sequesters vitamin E resulting in local deficiency and exacerbating metabolic dysfunction, which may be mitigated by supplementation. We conducted pharmacokinetics studies in 6 obese women with MASLD and 10 healthy controls, using vitamin E labeled stable isotopes. MASLD cohort had significantly reduced vitamin E bioavailability that correlated with liver fat, suggesting a fat-mediated vitamin E sequestration. To investigate mitigative effect of vitamin E supplementation, we used a mouse model of MASLD fed a regular diet or a western diet (high fat/high sugar) with 500 IU/Kg or <25 IU/Kg of vitamin E. We monitored mouse weights and assessed metabolic parameters using calorimetric chambers. Liver, liver fat and vitamin E levels were also measured. Mice on a high-fat diet with high vitamin E gained less weight, had increased hepatic and plasma vitamin E levels, decreased oxygen consumption, and lower fat mass compared to those on the same diet with low vitamin E. Furthermore, mice fed with high E had a lower grade of steatohepatitis, assessed by histopathology. Findings suggest potential preventative role of vitamin E supplementation in MASLD.

Scientific Focus Area: Clinical Research

This page was last updated on Tuesday, August 6, 2024

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Current Research Festival

  • 2025
  • 2024
    • General Schedule of Events
    • 2024 NIH Distinguished Scholars Program
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • National Academy of Science Mini-Symposium
    • Special Wednesday Events
    • Vendor Exhibit Information
    • Green Labs Fair
    • Research Festival Committee
  • 2023
    • General Schedule of Events
    • NIH Early–Career Investigator Lectures
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • Vendor Exhibit Information
    • Research Festival Committee
  • 2021
  • 2019
    • General Schedule of Events
    • Plenary Sessions
    • Poster Session
    • Data Blitz
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committee
  • 2018
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    • Concurrent Symposia Sessions
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    • Special Exhibits on Resources for Intramural Research
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  • 2017
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    • Concurrent Symposia Sessions
    • Poster Sessions
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  • 2016
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