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NIH Research Festival

September 23 – 25, 2024

Qualitative Tissue Analysis Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF)

Authors

  • Z Saleem
  • L Scarpelli
  • S Burks
  • J Frank
  • D Agrohia
  • H Kalish

Abstract

Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry is a versatile analytical technique capable of targeting a wide range of biomolecules. MALDI-TOF imaging mass spectrometry facilitates the label-free acquisition of qualitative data in a two-dimensional format, enhancing our understanding of molecular distributions. Tissue slides undergo a series of washes and are coated with specialized matrices to optimize lipid, peptide, or protein expression. This preparation is critical for accurate analysis. Statistical analysis produces heat maps and identifies specific regions within tissues, providing detailed spatial molecular information. MALDI-TOF imaging mass spectrometry offers valuable insights into the spatial molecular characteristics of various tissue types. Its unique capabilities make it an indispensable tool in biomarker detection and discovery, ensuring reliable and reproducible results.

Scientific Focus Area: Immunology

This page was last updated on Tuesday, August 6, 2024

Download or preview the program here

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Current Research Festival

  • 2025
  • 2024
    • General Schedule of Events
    • 2024 NIH Distinguished Scholars Program
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • National Academy of Science Mini-Symposium
    • Special Wednesday Events
    • Vendor Exhibit Information
    • Green Labs Fair
    • Research Festival Committee
  • 2023
    • General Schedule of Events
    • NIH Early–Career Investigator Lectures
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • Vendor Exhibit Information
    • Research Festival Committee
  • 2021
  • 2019
    • General Schedule of Events
    • Plenary Sessions
    • Poster Session
    • Data Blitz
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committee
  • 2018
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committees
  • 2017
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
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    • Browse by Presenter Name
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