The NIA Nonhuman Primate Core Program: Translational Aging Research

Authors

• KC Toepfer
• KL Vaughan
• JA Mattison

Abstract

The NIA Nonhuman Primate Core is a one-of-a-kind resource funded by the Intramural research program to provide access to a translational research model, the rhesus monkey (Macaca mulatta), which is crucial to bridging the gap between the bench and the bedside. The Core provides a mechanism for intramural and extramural investigators to conduct in vivo translational research projects using rhesus monkeys, a species with 93% genetic homology to humans. The NHP Core was established in 2012 and is located at the NIH Animal Center in Poolesville MD. The Core supports a broad scientific research agenda to understand the nature of aging and explore the mechanisms that may extend the healthy years of life. It serves as a unique translational research resource to investigators in NIA, within the NIH, and across the country. The Core maintains approximately 120 male and female rhesus monkeys ranging from 3-30 years old. It is a heterozygous population of monkeys, making it a more appropriate model of the human population. With this colony, both cross-sectional and longitudinal analyses are possible. Study types include proof of concept, intervention trials, PK studies, exercise trials, and cognitive tasks. Research topics relate to immunology, cardiovascular physiology, microbiome, muscle physiology, age-related diseases, and more. With the investigator, our team develops the protocol, submits it for ACUC review, conducts the in vivo study, and delivers the samples and data. Our primary focus is providing exceptional research services and an accessible path to translational research using nonhuman primates.

Scientific Focus Area: Research Support Services

This page was last updated on Tuesday, August 6, 2024