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NIH Research Festival

September 23 – 25, 2024

Integrative analysis of the rare endocrine cancers using multi-omics data

Authors

  • SV Daulatabad
  • A Jain
  • D Nousome
  • M Tandon
  • D Varghese
  • K Pendo
  • MFW Malone
  • J del Rivero
  • BC Widemann
  • KM Reilly

Abstract

Endocrine cancers, including thyroid, adrenal, pituitary, and endocrine pancreatic cancers, are rare and understudied due to limited biospecimens and genomic data. We employed multi-omics approaches—RNA sequencing, whole-exome sequencing, and whole-genome sequencing—to elucidate molecular signatures and regulatory pathways in these cancers. We identified genes specific to various endocrine cancers, such as GNRHR, MMP9/12/13, TPH1, SLC6A2, and DRD2. Co-expression network analysis revealed distinct neuronal pathways associated with cancer progression. Integrating protein-protein interaction and multi-omic aberrant gene interaction networks, we discovered pathways involving noradrenaline biosynthesis in pheochromocytomas and calcitonin regulation in medullary thyroid carcinoma. Additionally, alternatively spliced genes in endocrine cancers were enriched in cancer hallmarks, including genomic instability. Our comprehensive multi-omic analysis offers novel insights into candidate therapeutic targets for these rare endocrine cancers.

Scientific Focus Area: Computational Biology

This page was last updated on Tuesday, August 6, 2024

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Current Research Festival

  • 2025
  • 2024
    • General Schedule of Events
    • 2024 NIH Distinguished Scholars Program
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • National Academy of Science Mini-Symposium
    • Special Wednesday Events
    • Vendor Exhibit Information
    • Green Labs Fair
    • Research Festival Committee
  • 2023
    • General Schedule of Events
    • NIH Early–Career Investigator Lectures
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • Vendor Exhibit Information
    • Research Festival Committee
  • 2021
  • 2019
    • General Schedule of Events
    • Plenary Sessions
    • Poster Session
    • Data Blitz
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committee
  • 2018
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
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    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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