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NIH Research Festival

September 23 – 25, 2024

Effects of cancer treatments on sleep patterns in men with non-metastatic prostate cancer

Authors

  • SG Gonsalves
  • SR LaMunion
  • KA Clevenger
  • T Wu
  • K Dickinson
  • A Ross
  • ME Steele
  • LN Saligan

Abstract

Background: Sleep disturbances are prevalent among men with non-metastatic prostate cancer (NMPC) undergoing treatment, and correct sleep assessment is crucial for comprehensive care. Research-grade actigraphy devices are valuable tools for evaluating sleep duration and quality. This study investigated the effects of androgen deprivation therapy (ADT) and external beam radiation therapy (EBRT) on sleep activity (SA) patterns of men with NMPC.
Methods: This NIH IRB-approved study (NCT00852111) enrolled men with NMPC receiving EBRT+ADT. Sleep data from Actical® and sleep logs of 98 men with NMPC (63 received EBRT, 35 active surveillance (AS) controls) were collected at three phases: Time 1 (pre-EBRT), Time 2 (mid-EBRT), and Time 3 (post-EBRT). Sleep efficiency (SE), sleep duration (SD), total sleep time (TST), wake after sleep onset (WASO), midsleep duration (MSD), and reported sleep time (RST) were extracted using the Tudor-Locke algorithm. Data filtration was implemented to remove sleep periods outside of 3-12 hours.
Results: At Time 1, no differences in sleep variables between AS and EBRT patients. Significant effect of treatments on WASO (p=0.034) was observed, specifically by ADT use (p=0.031). Participants using ADT exhibited higher WASO across all phases compared to non-users. Treatment phase significantly affected RST (p=0.041) with significant reductions mid-EBRT (425.59±67.36 minutes) compared to post-EBRT (476.63±88.68 minutes, p=0.01).
Conclusion: ADT use contributes to increased sleep fragmentation during and following EBRT in men with NMPC. Treatment phase appears to be a key factor influencing variations in RST, suggesting the importance of phase-specific interventions to manage sleep disturbances in this population.

Scientific Focus Area: Clinical Research

This page was last updated on Tuesday, August 6, 2024

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Current Research Festival

  • 2025
    • Posters Session
    • General Schedule of Events
  • 2024
    • General Schedule of Events
    • 2024 NIH Distinguished Scholars Program
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • National Academy of Science Mini-Symposium
    • Special Wednesday Events
    • Vendor Exhibit Information
    • Green Labs Fair
    • Research Festival Committee
  • 2023
    • General Schedule of Events
    • NIH Early–Career Investigator Lectures
    • Poster Sessions
    • Concurrent Workshops
    • NIH Resource Information Fair
    • Vendor Exhibit Information
    • Research Festival Committee
  • 2021
  • 2019
    • General Schedule of Events
    • Plenary Sessions
    • Poster Session
    • Data Blitz
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committee
  • 2018
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committees
  • 2017
    • General Schedule of Events
    • Plenary Sessions
    • Concurrent Symposia Sessions
    • Poster Sessions
    • FARE Award Ceremony
    • Future Research Leaders
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committees
  • 2016
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