Association between Body Mass Index and Waist-Hip Ratio and Prostate Cancer among European American and African American Men: the NCI-MD case-control study

Authors

• MS Pichardo
• CJ Smith
• W Tang
• T Dorsey
• D Mann
• S Ambs

Abstract

Introduction: This year prostate cancer (PCa) is projected to be the second leading cause of death in African American (AA) men. Obesity may increase the risk of PCa in European American (EA), but this association is inconsistent among AA men. Therefore, we aim to compare the association between obesity and PCa in EA and AA men. Methods: Using multivariate logistic regression analysis, we estimate the risk of total, high grade and high stage PCa for 976 cases and 1,032 age-matched controls, with equal proportions of EA and AA. Total risk is also analyzed by stratifying by grade, stage, and age-of-onset. Results: Being overweight increased the risk of total PCa, while waist-hip-ratio>1 increased the risk of high stage and grade disease among EA incident cases. For EA incident cases in the high grade strata, being overweight increased the risk of total PCa; but for men with PCa age-of-onset ≤65, obesity decreased the risk of PCa. For EA prevalent cases in the high stage strata, being overweight or obese increased the risk of total PCa. For AA incident cases, obesity decreased the risk of total and high stage PCa in overall analysis and of total PCa across all strata. For AA prevalent cases in high grade, low stage, and both age-of-onset strata, obesity decreased the risk of total PCa. Conclusion: Our findings suggest that overall obesity may protect against risk of PCa and high stage disease for AA; while for EA, abdominal obesity is a more important risk factor for PCa incidence.

Scientific Focus Area: Epidemiology

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