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SBR-Blood: Systems Biology Repository for Hematopoietic Cells

Thursday, September 17, 2015 — Poster Session II

12:00 p.m. – 1:30 p.m.
FAES Terrace
NHGRI
SYSBIO-3

Authors

  • J Lichtenberg
  • EF Heuston
  • T Mishra
  • CA Keller
  • RC Hardison
  • DM Bodine

Abstract

Extensive research into hematopoiesis (the development of blood cells) over several decades has generated large sets of expression and epigenetic profiles in multiple human and mouse blood cell types. However, there is no single location to analyze how gene regulatory processes lead to different mature blood cells. We have developed a new database framework called hematopoietic Systems Biology Repository, or SBR-Blood, that allows user-initiated analyses for cell type correlations or gene-specific behavior during differentiation using publicly available datasets for array- and sequencing-based platforms from hematopoietic cells. SBR-Blood organizes information by both cell identity and by hematopoietic lineage. The validity and usability of SBR-Blood has been established through the reproduction of workflows relevant to expression data, DNA methylation, histone modifications and transcription factor occupancy profiles. SBR-Blood is accessible at http://sbrblood.nhgri.nih.gov.

Category: Systems Biology