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NIH Research Festival

September 16 – 18, 2015

Human Artificial Chromosomes (HACs) Vectors for Human Gene Delivery and Drug Screening

Friday, September 18, 2015 – Poster Session IV
12:00 – 1:30 p.m.

FAES Terrace

NCI

GEN-26

Authors

  • JH Kim
  • HS Lee
  • NC Lee
  • N Kouprina
  • V Larionov

Abstract

Human artificial chromosomes (HACs) based vectors have several advantages over viruses as gene delivery vectors and the ability to carry large gene inserts. HACs avoid the limited cloning capacity, lack of copy number control, and insertional mutagenesis caused by integration into host chromosomes that plague viral vectors. HAC vectors also have a great potential for screening of anticancer drug. HACs allow therapeutic transgenes to be expressed in target cells under conditions that recapitulate the physiological regulation of endogenous loci. Here we summarize our recent work on gene transfer into human cells using the HACs for complementation studies as well as the use of HACs for screening of new drugs affecting chromosome instability.

Scientific Focus Area: Genetics and Genomics

This page was last updated on Friday, March 26, 2021

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2015 program

Download the 2015 Research Festival Schedule Overview (6 pages)

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Current Research Festival

  • 2025
  • 2024
    • General Schedule of Events
    • 2024 NIH Distinguished Scholars Program
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    • NIH Resource Information Fair
    • National Academy of Science Mini-Symposium
    • Special Wednesday Events
    • Vendor Exhibit Information
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    • Research Festival Committee
  • 2023
    • General Schedule of Events
    • NIH Early–Career Investigator Lectures
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    • Concurrent Workshops
    • NIH Resource Information Fair
    • Vendor Exhibit Information
    • Research Festival Committee
  • 2021
  • 2019
    • General Schedule of Events
    • Plenary Sessions
    • Poster Session
    • Data Blitz
    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
    • Research Festival Committee
  • 2018
    • General Schedule of Events
    • Plenary Sessions
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    • FARE Award Ceremony
    • Special Exhibits on Resources for Intramural Research
    • Technical Sales Association (TSA) Research Festival Exhibit Tent Show
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  • 2015
    • General Schedule of Events
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