Effect of bivalent human papillomavirus (HPV) vaccination on pregnancy outcomes: long-term observational follow-up in the Costa Rica HPV Vaccine Trial

FARE Award Winner

Authors

• OA Panagiotou
• B Befano
• P Gonzalez
• AR Rodríguez
• R Herrero
• JT Schiller
• AR Kreimer
• M Schiffman
• A Hildesheim
• AJ Wilcox
• S Wacholder
• Costa Rica HPV Vaccine Trial

Abstract

Objectives: To examine the effect on miscarriage of the bivalent HPV vaccine. Design: Observational long-term follow up of a randomized trial combined with an independent unvaccinated population-based cohort in Costa Rica. Participants: 7,466 women enrolled in the trial and 2,836 women in the unvaccinated cohort enrolled Intervention: Women in the trial were assigned to receive three doses of bivalent HPV 16/18 (HPV2, n=3,727) or the control hepatitis A vaccine (HAV; n=3,739). Crossover HPV2 vaccination occurred in the HAV arm at the end of the trial. The unvaccinated cohort did not receive any vaccination. Results: Relative risk (RR) of miscarriage for pregnancies conceived

Scientific Focus Area: Epidemiology

This page was last updated on Friday, March 26, 2021