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Effect of bivalent human papillomavirus (HPV) vaccination on pregnancy outcomes: long-term observational follow-up in the Costa Rica HPV Vaccine Trial

Friday, September 18, 2015 — Poster Session V

2:00 p.m. – 3:30 p.m.
FAES Terrace
NCI
EPIG-13

* FARE Award Winner

Authors

  • OA Panagiotou
  • B Befano
  • P Gonzalez
  • AR Rodríguez
  • R Herrero
  • JT Schiller
  • AR Kreimer
  • M Schiffman
  • A Hildesheim
  • AJ Wilcox
  • S Wacholder
  • Costa Rica HPV Vaccine Trial

Abstract

Objectives: To examine the effect on miscarriage of the bivalent HPV vaccine. Design: Observational long-term follow up of a randomized trial combined with an independent unvaccinated population-based cohort in Costa Rica. Participants: 7,466 women enrolled in the trial and 2,836 women in the unvaccinated cohort enrolled Intervention: Women in the trial were assigned to receive three doses of bivalent HPV 16/18 (HPV2, n=3,727) or the control hepatitis A vaccine (HAV; n=3,739). Crossover HPV2 vaccination occurred in the HAV arm at the end of the trial. The unvaccinated cohort did not receive any vaccination. Results: Relative risk (RR) of miscarriage for pregnancies conceived

Category: Epidemiology