Comparison of three topical treatments against ulcerative dermatitis in mice with a C57BL/6 background

Authors

• CR Michaud
• J Qin
• WR Elkins
• AS Gozalo

Abstract

Ulcerative dermatitis (UD) is a common condition in C57BL/6 mice and strains with that background. The etiology of UD is still unclear but appears to have a genetic component associated to the C57/BL6 background strain and has been reported as secondary to a variety of conditions. Treatment is unrewarding in many cases resulting in euthanasia of the affected animal. In the present study we compared three topical treatments against spontaneous UD in mice with a C57BL/6 background. A total of 301 adult mice of both sexes were randomly assigned to one of three topical treatments. Group 1 mice were treated with bacitracin-neomycin sulfate-polymixin B sulfate ointment twice a day, Group 2 were treated with 10% povidone-iodine ointment plus 1% silver sulfadiazine cream once a day, and Group 3 were treated with 0.005% sodium hypochlorite once a day. Sex, age, lesion location, type of treatment, and length of treatment were analyzed using univariate and multivariate logistic regression using S-plus software package. In Group 1, 27 out of 79 (34.17%) animals healed. In Group 2, 43 out of 125 (34.40%) healed, and in Group 3, 69 out of 97 (71.13%) healed. Lesion size and treatment with 0.005% sodium hypochlorite were the only significant predictors of healing (P

Scientific Focus Area: Research Support Services

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