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Cyclic AMP signaling in the nervous system: A translational perspective

Monday, September 22, 2014 — Concurrent Symposia Session I

2:00 p.m. – 4:00 p.m.

Classroom 4


  • Lee Eiden, NIMH


This symposium will dissect and review the parcellation of cAMP signaling in the nervous system based on the anatomical diversity of expression of Gs-coupled GPCRs, cAMP sensors, cyclic nucleotide phosphodiesterases, and cyclic nucleotide-gated cation channels, and discuss how new imaging methods, high-throughput screening, and high-content screening have transformed this field, ripening it for translational research and drug discovery.

Rolipram-based PET Ligands-Imaging cAMP Dynamics In the Human Brain In Vivo
Robert Innis, NIMH

Vasopressin regulates the water channel aquaporin-2 through multiple cAMP-dependent signaling pathways
Mark Knepper, NHLBI

Dopamine receptors-signaling through multiple pathways and relevance to design of receptor-specific biased ligands
David Sibley, NINDS

Regulation of adult stem cells by Gs/cAMP/PKA signaling; FARE award winner
Ramiro Iglesias-Bartolome, NIDCR

Neuroendocrine cell-specific and cell-ubiquitous cAMP sensors and their roles in neuronal GPCR Signaling
Lee Eiden, NIMH

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