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Role of the autophagic and endo/lysosomal systems in disease and survival

Tuesday, September 23, 2014 — Concurrent Symposia Session III

2:00 p.m. – 4:00 p.m.

Classroom 4


  • Rosa Puertollano and Nihal Altan-Bonnet, NHLBI
  • Peng Loh, NICHD


This symposium will bring together a unique group of scientists from across NIH to highlight their recent pioneering studies on the role of cellular autophagy and endo/lysosomal membrane systems in disease and survival. The autophagosomal and endo/lysosomal membrane systems are critical for maintaining protein and lipid homeostasis and overall organelle and cell identity. Cutting edge basic and translational research will be presented on the mechanisms by which the autophagosomal and endo/lysosomal membrane systems and their associated machinery can maintain cell survival during periods of cell stress; can be hijacked by pathogens to promote replication, assembly and export; and can also lead to devastating neurodegenerative disorders such as Parkinson’s disease and spastic paraplegia when disrupted.

Adaptation of the endo/lysosomal pathway to starvation and stress
Rosa Puertollano, NHLBI

Autophagosomes as viral cluster bombs to disseminate infection
Nihal Altan-Bonnet, NHLBI

Exploitation of the endo/lysosomal system by invading bacteria
Olivia Steele-Mortimer, NIAID

Common lysosomal defects in autosomal recessive hereditary spastic paraplegias
Craig Blackstone, NINDS

LRRK2 and selective autophagy; relevance for Parkinson's disease
Mark Cookson, NIA

Exploring the role of the MiTF/TFE family of transcription factors in Parkin-mediated mitophagy; FARE award winner
Catherine Nezich, NINDS

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