Stem cells in development and diseases

Tuesday, September 23, 2014 — Concurrent Symposia Session II
10:00 a.m. – 12:00 p.m.	Classrooms 6 and 7

Chair

• Steven Hou, NCI

Program

Tissues and organs in animals are generated and maintained by stem cells. Similarly, oncogenic mutations and metabolic reprogramming may drive tumor development through cancer stem cells (CSCs) or also called tumor-initiating cells (TICs). Stem cells have immense potential for therapeutic use in regenerative medicine and as targets for anticancer therapies. To make use of this potential, we must first understand the molecular parameters that define a stem cell and the mechanisms that regulate stem-cell behaviors. This symposium will include speakers studying stem cells in development, somatic cell reprogramming, tumor-initiating cells in cancers, and clinical applications of stem cells.

The novel tumor suppressor Madm regulates stem cell competition in Drosophila testis
Steven Hou, NCI

Wnt signaling and the regulation of stem cell fate
Terry Yamaguchi, NCI

Lineage specific stem cells in the skin
Isaac Brownell, NCI

Transcriptional and post-transcriptional regulation of embryonic stem cell self-renewal
Guang Hu, NIEHS

Stem-Cell derived vascular progenitor cells in regenerative medicine
Manfred Boehm, NHLBI

Skeletal stem cells: Their role in disease and regeneration
Pamela Robey, NIDCR

CBFß and RUNX1 are required at two different steps during the development of hematopoietic stem cells; FARE award winner
Erica Bresciani, NHGRI

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