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The role of cues and contexts in adaptive and maladaptive behaviors: From mice to humans

Monday, September 22, 2014 — Concurrent Symposia Session I

2:00 p.m. – 4:00 p.m.

Classrooms 1 and 2


  • Kenzie Preston, NIDA
  • Yavin Shaham, NIDA


We will present research on basic mechanisms in rodent models and translational research in humans on the role of cues and contexts in adaptive and maladaptive behaviors. 1. There is growing recognition that maladaptive, habit-driven behaviors underlie many chronic diseases. Learned behaviors are strongly influenced by cues and context. Better understanding of the mechanisms of cue/context learning and their relationship to behavior could lead to better interventions to promote human health and cognition with aging and to treat psychiatric diseases like addiction. 2. Our symposium is comprised of researchers (3 on tenure-track) from three institutes who will present both basic research and translational research. We will cover diverse topics, including stress, addiction, learning, genetics, and neurogenesis. These topics should be of interest not only for NIA, NIDA, and NIAAA researchers, but also for researchers from many other institutes, because of the broad impact of health-related behaviors in many chronic diseases.

Detection and discrimination of motivationally salient cues by basal forebrain neurons
Shih-Chieh Lin, NIA

Modulation of cue separation discrimination and new hippocampal neurons by physical activity
Henriette van Praag, NIA

Context-induced relapse to drug seeking during abstinence induced by adverse consequences
Yavin Shaham, NIDA

Alcohol craving and cues in human laboratory pharmacotherapy studies
Lorenzo Leggio, NIDA, NIAAA

Environmental context of drug use, craving and stress in polydrug users
Kenzie Preston, NIDA

Clonidine maintenance prolongs opioid abstinence and decouples stress from craving in daily life: A randomized controlled trial with ecological momentary assessment; FARE award winner
Bill Kowalczyk, NIDA

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